Comparative studies on growth of foot-and-mouth disease virus types 0 and Asia 1 in BHK-21 Razi cells.
0
Citation
0
Reference
10
Related Paper
Abstract:
Growth pattern of foot-and-mouth disease virus types 0 and Asia 1 in BHK-21 Razi cells was compared; while type 0 virus grew in high titre, Asia 1 virus was produced in low titre. Inhibition of host protein synthesis in type 0 virus-infected cells was more pronounced than in Asia 1 virus-infected cells. Foot-and-mouth disease virus type 0 infected cells showed higher lactic dehydrogenase activity when compared to Asia 1 virus. A significant decrease in virus yield was observed when Actinomycin D had been added at 50 micrograms/ml to infected cells.Cite
Medical microbiology
Veterinary virology
Aphthovirus
Antigenic variation
Cite
Citations (19)
clone (Java method)
Recombinant virus
Cite
Citations (2)
Gailiunas, Peter (Plum Island Animal Disease Laboratory, Greenport, N. Y.), and George E. Cottral . Presence and persistence of foot-and-mouth disease virus in bovine skin. J. Bacteriol. 91: 2333–2338. 1966.—This study established that the seven known antigenic types of foot-and-mouth disease virus (FMDV) have consistent affinity to all areas of bovine skin, even though gross cutaneous lesions usually are found only in the pedal area. Considerable amounts of FMDV were present in skin of 13 different body areas, irrespective of the presence of hair. All skin specimens from the trunk of 50 experimentally infected steers, necropsied from 12 hr to 7 days postinoculation (DPI), contained FMDV in the dermal and epidermal tissues. In skins of some steers, FMDV persisted for as long as 5 days after cessation of viremia. The highest average virus titer, 10 3.6 plaque-forming units (PFU) per g of skin, was found at 2 DPI. Some areas of the trunk and extremities had titers of approximately 10 5.0 PFU per g of skin. Characteristic gross lesions were not observed in sampling areas. The present observations have epizootiological importance for hides offered in international trade, because FMDV localized intracutaneously is more difficult to inactivate than virus adhering to hide surfaces.
Aphthovirus
Viremia
Cite
Citations (45)
Cite
Citations (9)
Antigenic variation
Aphthovirus
Strain (injury)
Cite
Citations (183)
Cite
Citations (4)
Amplicon
Primer (cosmetics)
Cite
Citations (111)
Virus-like particle
Cite
Citations (22)
Persistence (discontinuity)
Aphthovirus
Cite
Citations (36)
As seen by prior tragic outbreaks in many places throughout the world, the foot and mouth disease virus, or "FMDV," is one of the most critical challenges in animal health. In this review, the major features of FMDV, as well as aspects of its interactions with cells and hosts, were discussed. On the other hand, present and upcoming FMD treatment approaches. The first vertebrate virus found was the foot-and-mouth disease virus (FMDV). A capsid protein and the viral genome (+ve sense single strand RNA) make up FMDV. The icosahedral symmetry of the viral structure is made up of structural proteins (VP1, VP2, VP3, and VP4) as well as non-structural proteins (L, 1A, 1B, 1C, 1D, 2A, 2B, 2C, 3A, 3B, 3C, and 3D). The viral replication takes place in the cytoplasm of the cell. Because FMDV has a short incubation period, it spreads quickly. Direct contact is the most often used method of FMDV transmission. The occurrence of direct contact via aerosol and mechanical transmission (fomites, feed, and water). The immunological response is stimulated by the infection with FMD. However, due to virus antigenic diversity, the immune response does not always protect against FMD (antigenic shift). FMDV is divided into seven serotypes based on antigenic variation. O, A, C, SAT-1, SAT-2, SAT-3, and Asia-1 are the serotypes in question. O is the most frequent serotype.
Aphthovirus
Picornavirus
Cite
Citations (1)