Donor Specific Blood Transfusions and Successful Spousal Kidney Transplantation
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No AccessJournal of Urology1 Jun 1985Donor Specific Blood Transfusions and Successful Spousal Kidney Transplantation John M. Barry, Thomas Hefty, Susan M. Fischer, and Douglas J. Norman John M. BarryJohn M. Barry More articles by this author , Thomas HeftyThomas Hefty More articles by this author , Susan M. FischerSusan M. Fischer More articles by this author , and Douglas J. NormanDouglas J. Norman More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)49361-XAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Donor-specific blood transfusions have improved significantly 1-haplotype living related donor kidney transplant results. We have applied this concept successfully in 2 spousal kidney transplants. This technique may provide an additional source of kidney grafts, especially in developing countries without cadaver kidney transplant programs. © 1985 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 133Issue 6June 1985Page: 1024-1025 Advertisement Copyright & Permissions© 1985 by The American Urological Association Education and Research, Inc.MetricsAuthor Information John M. Barry More articles by this author Thomas Hefty More articles by this author Susan M. Fischer More articles by this author Douglas J. Norman More articles by this author Expand All Advertisement Loading ...Kidney transplants are at risk for so far unavoidable ischemia-reperfusion injury. Several experimental kidney transplantation models are available to study this injury, but all have their own limitations. Here, we describe precision-cut kidney slices (PCKS) as a novel model of kidney ischemia-reperfusion injury in comparison with pig and human kidney transplantation. Following bilateral nephrectomy in pigs, we applied warm ischemia (1h), cold ischemia (20h) and a reperfusion period (4h) to one whole kidney undergoing transplantation to a recipient pig and, in parallel, established PCKS undergoing ischemia and modeled reperfusion. Histopathological assessment revealed the presence of some but not all morphological features of tubular injury in PCKS as seen in pig kidney transplantation. RNAseq demonstrated that the majority of changes occurred after reperfusion only, with a partial overlap between PCKS and kidney transplantation, with some differences in transcriptional response attributable to systemic inflammatory responses and immune cell migration. Comparison of PCKS and pig kidney transplantation with RNAseq data from human kidney biopsies by gene set enrichment analysis revealed that both PCKS and pig kidney transplantation reproduced the post-reperfusion pattern of human kidney transplantation. In contrast, only post-cold ischemia PCKS and pig kidney partially resembled the gene set of human acute kidney injury. Overall, the present study established that a PCKS protocol can model kidney transplantation and its reperfusion-related damage on a histological and a transcriptomic level. PCKS may thus expand the toolbox for developing novel therapeutic strategies against ischemia-reperfusion injury.
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Hypoxia
Hypoxia-Inducible Factors
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Objective To study the effect of kidney transplantation in polycystic kidney patients reserving original kidney.Methods 12 cases of polycystic kidney receiving transplantation with original renal were retrospectively analyzed.Results 1 case was removed one side original kidney after operation for complication.11 cases all obtained good function of graft without removing original kidney. Conclusions The polycystic kidney patients receiving renal transplantation can obtain satisfactory clinical results reserving original kidney.
Artificial kidney
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Cadaveric spasm
Artificial kidney
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The objective of the present study was to describe kidney temperature variations during transplantation and to identify the factors responsible for kidney warming. Kidney temperature was recorded steadily during transplantation. Kidney weight, body mass index (BMI), second warm ischemia time (t), and kidney temperature at the time of being placed in the recipient were analyzed so that we could evaluate their influence on kidney temperature and on kidney warming during transplantation. Kidney temperature at the time of removal from the container was 1.6 degrees C and 6. 3 degrees C when the kidney was placed in the recipient. Kidney temperature in the recipient depended on kidney temperature after serum washing (P<0.0001), but was independent of kidney preparation time (P=0.94). Then, kidney temperature (T) increased according to the logarithmic curve given in the following equation: T=7.2 ln(t)-0.6. Kidney temperature at the end of anastomosis was 26.7 degrees C. Kidney warming speed was 0.48 degrees/min and was dependent on the length of time of vascular anastomosis (P<0.0001). Kidney weight decreased the kidney warming speed (P=0.02). In conclusion, kidney warming increases slowly during ex vivo preparation. Kidney temperature stays below the damaging ischemic temperature of 18 degrees C. Because of its major impact on kidney warming, it is desirable that vascular anastomosis time be reduced, and, consequently, ex vivo kidney preparation needs to be meticulous.
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Objectives To investigate the impact of donor kidney volume and renal function on posttransplant graft function.Methods The correlations of the donor kidney volnine , the renal function and the mean SCr 13.2 months after kidney transplantation were studied in 53 living kidney donor-recipient pairs.Results The donor kidney volume had an obvious impact on the mean SCr 13.2 months after kidney transplantation(r=0.539,p＜0.01).A donor kidney volume greater than 110 cm3 was independently associate with better GFR at the mean 13.2 months post-transplant when compared to recipients of lower donor kidney volume(81.19+16.5 vs 66.97+12.72 ml/min,p＜0.01);the donor kidney ideal function Wes positively correlated with the mean SCr 13.2months post-operation(r=0.363,p＜0.01).Conclusions The donor kidney volume and the rehal function are important factors that influence long-term allograft function after kidney transplantation.It is suggested that larger and good-functional kidneys should be preferred when selecting from otherwise similar living donors.
Key words:
Kidney Transplantation
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Nephrology
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