[Effect of mitochondrial DNA 5178 C/A polymorphism on risks for type 2 diabetes mellitus and its complications].
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To explore the role of mitochondrial DNA 5178 C/A (Mt5178) polymorphism of NADH-dehydrogenase subunit 2 (ND2) gene in type-2 diabetes mellitus (T2DM) among ethnic Han Chinese through a case-control study.The Mt5178C/A polymorphism was determined by sequencing 1103 T2DM patients and 791 healthy controls. Logistic regression analysis was conducted to estimate odds ratios (OR) and 95% confidence intervals (CI). To confirm the results, a meta-analysis was conducted based on published literature on the association of Mt5178 variant with T2DM.No significant association was found between the Mt5178C/A variant and T2DM either by our study or the meta-analysis which included eight published studies. Nevertheless, it was found that the T2DM patients with 5178C genotype were at a higher risk for nephropathy complication (OR=1.49, 95%CI: 1.005-2.197, P<0.05) and at significantly lower risk for hypertension complication (OR=0.744, 95%CI: 0.556-0.996, P<0.05) compared with those carrying a 5178A genotype.No association was found between the Mt5178C/A polymorphism of mitochondrial ND2 gene with the increased risk of T2DM. However, the polymorphism may affect the development of nephropathy and hypertension complications among T2DM patients.Several published literatures investigated the relation between a polymorphism (Leul25Val) in platelet endothelial cell adhesion molecule-1 (PECAM-1) gene and risk of coronary heart disease (CHD) and did not reach the same conclusion. To shed light on these inconclusive findings, we performed a meta-analysis of studies relating the PECAM-1 genetic polymorphism (Leul25Val) to the risk of CHD.We identified literatures by searching PubMed, EMBASE, Chinese National Knowledge Infrastructure databases (CNKI) and Wanfang database in China. Data from eligible studies were extracted for meta-analysis. CHD risk associated with PECAM-1 genetic polymorphism (Leul25Val) was estimated by pooled odds ratios (ORs) and 95% confidence intervals (95% CIs). The software Review Manager (Version 5.2) was used for meta-analysis. Publication bias was tested by funnel plot.A total of 15 studies comprising 3696 cases and 3940 controls fulfilled the inclusion criteria. Our results did not show that Leul25Val polymorphism in PECAM-1 gene was associated with the risk of CHD [(LL+LV) vs VV, OR = 1.15, 95% CI: 0.84-1.56, P = 0.38; (VV+LV) vs LL, OR = 0.96, 95% CI: 0.79-1.17, P = 0.69; V vs L, OR = 1.08, 95% CI: 0.92-1.27, P = 0.80, respectively] by a meta-analysis.The results of our meta-analysis suggested that Leul25Val polymorphism in PECAM-1 gene is not a susceptibility marker of CHD.
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Glutathione S-transferase T1 (GSTT1) null genotype has been indicated to be correlated with preterm delivery (PTD) susceptibility, but study results were still debatable. Thus, a meta-analysis was conducted. PubMed, EMBASE, and CNKI were searched. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strength of association in the random-effects model or fixed-effects model. Nine case-control studies with a total of 2526 cases and 4565 controls were eligible. The null genotype of GSTT1 was associated with a significantly increased risk of PTD when compared with present genotype (OR = 1.18; 95% CI 1.05-1.33; I(2) = 33). In the subgroup analysis according to ethnicity, significantly increased PTD risk was observed in Asians (OR = 1.20; 95% CI 1.01-1.33; I(2) = 0%) but not in Caucasians (OR = 1.32; 95% CI 0.89-1.97; I(2) = 77). This meta-analysis suggested that GSTT1 null genotype may be associated with the risk of PTD.
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This study aimed to investigate the association between the IL6 -174 G/C gene polymorphism and the risk of osteoporosis by performing a meta-analysis.Published literature from PubMed and Embase databases was searched for eligible publications. The following information was extracted from each study: Name of first author, year of publication, country of origin, sample size of cases and controls, and size of each allele. The combined odds ratio (ORs) and 95% confidence intervals (95%CIs) for the association between the IL6 -174 G/C gene polymorphism and the risk of osteoporosis were assessed using a random or fixed effects model. A comprehensive meta-analysis (CMA) 2.0 was used to analyse the data.Twelve studies (4923 cases/3431 controls) were included in this meta-analysis. The results indicated that IL6 -174 G/C gene polymorphism was associated with an increased (G vs C, OR 95%CI = 1.29 [1.03-1.62], p = 0.029) and decreased risk of osteoporosis (C vs G, OR 95%CI = 0.77 [0.62-0.97], p = 0.029; CC vs GG + GC, OR 95%CI = 0.58 [0.39-0.88], p = 0.010).The IL6 -174 G/C gene polymorphism was shown to be positively correlated with osteoporosis risk.تهدف هذه الدراسة للتحقيق في العلاقة بين تعدد الأشكال الجينية للجين IL 6-174 G/C وخطر هشاشة العظام باستخدام التحليل التلوي.تم البحث عن المقالات المنشورة في قاعدة المعلوماتPubMed و EMBASE المؤهلة للنشر. واُستخرجت المعلومات التالية من كل بحث: اسم الباحث الأول، سنة النشر، بلد المنشأ، حجم عينة الحالات والضوابط٬ وحجم كل أليل. كما تم تقييم نسبة الأرجحية المشتركة وفترة الثقة ٩٥٪ للعلاقة بين تعدد الأشكال الجينية للجين IL 6-174 G/C مع خطر هشاشة العظام باستخدام نموذج الأثر العشوائي أو الثابت. واستخدام التحليل التلوي الشامل لتحليل البيانات.شملت الدراسة ١٢ بحثا (٤٩٢٣حالة ⁄ ٣٤٣١ ضابطة) في التحليل التلوي. وأظهرت النتائج أن الجين IL 6-174 G/C متعدد الأشكال الجينية كان مرتبطا بزيادة (G vs C) وانخفاض خطورة حدوث هشاشة العظام (G vs C).أظهر الجين متعدد الأشكال IL 6-174 G/Cارتباطا إيجابيا مع خطورة حدوث هشاشة العظام.
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Objective To investigate the association between the solute carrier family 6 member 4 ( SLC6A4) gene L/S polymorphism and pulmonary arterial hypertension (PAH). Methods The relevant literature was retrieved from the PubMed® database and the data were extracted. STATA® version 12.0 software was used to calculate pooled odds ratios (ORs) and 95% confidence intervals (CI). Results Eight case–control studies qualified for inclusion in the meta-analysis. These studies included 1215 cases and 936 control subjects. There was no significant association between the SLC6A4 gene L/S polymorphism and PAH risk in the total population (LL versus SS: OR 1.83, 95% CI 0.95, 3.51; LS versus SS: OR 1.37, 95% CI 0.93, 2.02; dominant model: OR 1.38, 95% CI 0.97, 1.97; recessive model: OR 1.54, 95% CI 0.84, 2.83). Subgroup analysis based on study quality scores and Hardy–Weinberg equilibrium also showed no significant association. Conclusion The findings of this meta-analysis suggest that the SLC6A4 gene L/S polymorphism is unlikely to be related to PAH risk. Well-designed studies with more participants will be required to validate these results.
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Objective To comprehensively explore the correlation between TNF-α-238 site gene polymorphism and pneumoconiosis susceptibility by using the method of Meta analysis.Methods We collected the literatures on case-control studies about the relationship between TNF-α-238 gene polymorphism and pneumoconiosis susceptibility by online retrieval of CNKI,Wanfang database and PubMed database.The results meeting the conditions were analyzed by Meta analysis.The pooled odds ratio(OR) and 95% confidence interval(95%CI) were calculated by RevMan4.2 software.Results Nine literatures published both at home and abroad were enrolled in the study,including 1,214 patients and 1,077 controls.The results of Meta analysis showed that there were statistically significant differences in the distribution frequency of GA+AA genotype between the patients and the controls(P0.05).Conclusions The relevant research results of Meta analysis show that TNF-α-238 gene polymorphism is associated with the occurrence of pneumoconiosis.The risk of pneumoconiosis in dust workers with GA+AA genotype is significantly higher than ones with GG genotype.And dust workers with GA+AA genotype are more likely to suffer severe pneumoconiosis.
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Introduction: The effect of angiotensin-converting enzyme ( ACE) insertion/deletion (I/D) polymorphism on risk of diabetic nephropathy (DN) is still conflicting. The present meta-analysis was performed to evaluate the overall risk of this polymorphism associated with DN in different groups. Materials and methods: A predefined search was performed on 14,108 DN cases and 12,472 controls from 63 published studies by searching electronic databases and reference lists of relevant articles. Results: In this meta-analysis, we found a significant association between the ACE I/D polymorphism and the risk of DN for all genetic models (ID versus II: odds ratio [OR] = 1.12, 95% confidence interval [CI] 1.02–1.24; DD versus II: OR = 1.27, 95% CI 1.13–1.44; allele contrast: OR = 1.15, 95% CI 1.08–1.23; dominant model: OR = 1.18, 95% CI 1.07–1.31; and recessive model: OR = 1.18, 95% CI 1.08–1.30, respectively). In stratified analysis by ethnicity and DM type, we further found that the Asian group with type 2 diabetes mellitus (T2DM) showed a significant association for all genetic models (ID versus II: OR = 1.25, 95% CI 1.07–1.47; DD versus II: OR = 1.57, 95% CI 1.24–1.98; allele contrast: OR = 1.30, 95% CI 1.15–1.46; dominant model: OR = 1.37, 95% CI 1.10–1.69; and recessive model: OR = 1.34, 95% CI 1.15–1.56, respectively). Conclusions: Our study suggested that the ACE I/D polymorphism may contribute to DN development, especially in the Asian group with T2DM.
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Studies on the relationship of HAP1 polymorphisms (-141 T > G; 1349 T > G) and lung cancer risk to date indicated controversial results. This study was devised to clarify whether the polymorphisms predispose to lung cancer. We searched Embase and PubMed up to March 2014 to identify relevant studies. Data from the eligible studies were independently extracted by two investigators. Pooled odds ratio (OR) was calculated to assess the associations between lung cancer risk and the abovementioned polymorphisms. A total of 15 case-control studies were included in this meta-analysis. Both overall analysis and stratified analysis by ethnicity and smoking status indicated no association between lung cancer risk and the 1349 T > G polymorphism. However, a significantly reduced risk of lung cancer was found among carriers of the GG genotype of the -141 T > G polymorphism, as compared with those of the TT genotype (homozygote model: OR = 0.82, 95% confidence interval (CI) 0.73 to 0.93, P(OR) = 0.002). Likewise, the GG genotype was also found to decrease lung cancer risk compared to the GT + TT genotypes (recessive model: OR = 0.82, 95 % CI 0.73 to 0.92, P(OR) = 0.001). Our meta-analysis suggests that the -141 T > G polymorphism, but not the 1349 T > G polymorphism, may have protective effects for lung cancer.
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To clarify the relationship between the b-fibrinogen (FGB) genetic polymorphism (-148C>T) and ischemic stroke, we identified studies by searching PubMed, EMBASE, and the Chinese National Knowledge Infrastructure (CKNI) databases.Data from eligible studies were extracted and subjected to meta-analysis.Publication bias was tested using a funnel plot.We identified 12 independent case-control studies containing 1536 ischemic stroke patients and 1329 control subjects.Our results showed that the -148C>T polymorphism in the FGB gene was associated with an increased risk of ischemic stroke [CC vs (TT+CT), odds ratio = 0.69, 95% confidence interval (CI) = 0.59-0.80,P < 0.0001; TT vs (CC+CT), odds ratio = 3.01, 95%CI = 1.29-7.05;P = 0.01; T vs C, odds ratio = 1.32, 95%CI = 1.15-1.52,P < 0.0001] by a meta-analysis.The results of our meta-analysis suggested that the -148C>T polymorphism in the FGB gene is a susceptibility marker of ischemic stroke.
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Previous case-control studies have suggested that the -1562C/T and R279Q polymorphisms of the matrix metalloproteinase 9 gene (MMP9) are associated with coronary heart disease (CHD). However, other studies do not confirm these relationships. The objective is to assess these relationships using meta-analysis.Databases, including PubMed and ScienceDirect, were searched to access the genetic association studies. Then data were extracted. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated. Moreover, subgroup and sensitive analysis were performed.The meta-analysis of the -1562C/T polymorphism included 12 studies with 8,336 cases and 3,984 controls. The -1562T allele was significantly associated with CHD (OR 1.25, 95% CI 1.08-1.45, p = 0.004). There was heterogeneity among the 12 studies (I2 = 61%, p = 0.003). The overall results were consistent and were not changed substantially by the removal of any data set. The meta-analysis of the R279Q polymorphism, including 6 studies with 6,983 cases and 3,282 controls, showed that the R279Q polymorphism was not associated with CHD (p = 0.16).The synthesis of available evidence supports the fact that the MMP9 -1562C/T polymorphism is a risk factor for CHD.
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Background: The interaction between genetic and environmental factors has resulted in growing prevalence of obesity around the world. IL6-174 G/Cgene polymorphism is widely studied as the involved factor in developing obesity. Objectives: The aim of the present study is to evaluate the relationship between Interleukin 6-174 G/C promoter gene polymorphism and obesity in a systematic review and meta-analysis study. Methods: In the present study Science Direct,Medline, Embase, Google Scholar, PubMedand SID search engines have been searched until March 2016. Articles were evaluated using the key words IL6 plus polymorphism or mutation or variant and adiposity, BMI and obesity. Data was analyzed using STATA software (12th version). OR ratio was calculated with 95% confidence interval to evaluate the strength in link between IL6 gene and obesity. Heterogeneity was calculated using I2 test. Articles bias was evaluated using funnel plot versus standard error (SE). The asymmetrydegree of the funnel plot was tested using linear regression tests ofEgger's and Begg's. Results: Generally, 12 articles entered systematic review and 6 articles entered final meta-analysis. After data was extracted, the total case group consisted of 5343 people and control group consisted of 3449 people. The odds ratio was estimated for additive model CC vs GC (OR= 1; CI: 95%: 0/9-1/12), recessive model CC + GC vs GG (OR= 1/04; CI: 95%: 0/95- 1/15) and for dominant model (OR= 1/10; CI: 95%: 1-1/21). Also the results showed that there is a statistically significant relationship between IL-61-74 G/C gene polymorphism and obesity (P
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