Infection and Renal Transplantation
23
Citation
17
Reference
10
Related Paper
Cirrhosis and hepatoma at Boston City Hospital have progressively increased in frequency, especially cirrhosis associated with chronic alcoholism. Alcoholic cirrhosis or fatty nutritional cirrhosis (FNC) increased from 31% (1917-1926) to 61% (1955-1968) of all types of cirrhoses. One third of 98 subjects dying of hepatoma had FNC. The occurrence of hepatoma associated with postnecrotic cirrhosis increased twofold and threefold in subjects with hemochromatosis. Chronic alcoholism was considered the pathogenetic agent implicated in the production of FNC, hemochromatosis, and post-necrotic cirrhosis in 56 of our 98 patients dying of hepatoma. An average of 8 years ensued from the onset of alcoholic cirrhosis to the appearance of hepatoma in 23 alcoholic patients.
Chronic hepatic
Cite
Citations (92)
Cite
Citations (101)
Objective To study the clinical value of color Doppler flow imaging in the diagnosis of patients with liver cirrhosis.Methods The blood flow of the portal vein and indexes of fibrosis were determined in patients with liver cirrhosis by portal vein color Doppler and radioimmunoassay(RIA).Results The indexes of liver cirrhosis group were higher than that in control group,that contents dropped as Child Pugh grade;The indexes of active liver cirrhosis were higher than that in resting liver cirrhosis.Conclusion Color Doppler flow imaging not only can help to make diagnosis of liver cirrhosis but also can assess the severty of the liver lesions in patients with liver cirrhosis.
Color doppler
Cite
Citations (0)
alpha 1-Antitrypsin levels were measured in sera of 134 patients with cirrhosis and in 64 with cirrhosis and hepatoma. S-TIC was determined in 105 patients with cirrhosis and in 54 with cirrhosis and hepatoma. The mean alpha 1-at and S-TIC values in patients with cirrhosis were 369.59 +/- 14.072 mg% and 1,808 +/- 0.05 mg/ml respectively. In patients with cirrhosis and hepatoma the mean alpha 1-at level was 406.595 +/- 17.834 mg% and the S-TIC mean values was 2.064 +/- 0.82 mg/ml. Although these values are higher than those found in the healthy controls, the differences are not statistically significant.
Alpha (finance)
Cite
Citations (5)
Serotoninergic mechanisms are thought to play a role in portal hypertension. Because this biomine is metabolized by the liver, peripheral blood and plasma levels of 5-hydroxytryptamine and 5-hydroxyindole acetic acid (the main metabolite of 5-hydroxytryptamine) were measured in 30 patients with cirrhosis. Whole-blood 5-hydroxytryptamine levels were significantly lower in patients with cirrhosis (158 +/- 28 nM) than in age-matched controls (332 +/- 19 nM), and no correlation was found between these levels and the severity of cirrhosis. Unconjugated plasma 5-hydroxytryptamine levels, an indication of the active form of 5-hydroxytryptamine, were significantly higher in patients with cirrhosis than in controls (6.8 +/- 1.7 nM and 3.4 +/- 0.5 nM, respectively), and in patients with cirrhosis these levels were higher in Pugh grade A than in Pugh grade C patients. Conjugated-plasma 5-hydroxytryptamine levels were not significantly different between patients with cirrhosis (32.2 +/- 8.1 nmol/L) and controls (16.4 +/- 1.4 nmol/L). Plasma 5-hydroxyindole acetic acid was significantly lower in patients with cirrhosis than in controls (1.5 +/- 0.1 nmol/L and 2.3 +/- 0.1 nmol/L, respectively). In conclusion, this study shows that serotoninergic mechanisms are altered in patients with cirrhosis.
Plasma levels
Cite
Citations (44)
The term `cirrhosis` is used for two centuries to define the end-stage of chronic liver diseases with different etiologies. Clinical manifestations of cirrhosis are related to portal hypertension, hepatic dysfunction progressing to liver failure and development of hepatocellular carcinoma, conditions with unfavorable prognosis. However, recent advances in the diagnosis and treatment of chronic liver diseases have changed the natural history of cirrhosis significantly. According to current concept, liver cirrhosis is heterogeneous, multi-stage condition with variable prognosis. Cirrhosis is considered as a dynamic, biphasic process, based on numerous clinical reports indicating the reversal of advanced fibrosis and cirrhosis after cessation of perpetual injury. This review was focused on current pathology and clinical staging of cirrhosis. The potential mechanism and proves of concept for reversibility of cirrhosis were also discussed.
Etiology
Cite
Citations (6)
Purpose: Weight and lifestyle play important roles in the development of many diseases. The aim of this study is to evaluate weight and lifestyle in the development of cirrhosis in the setting of chronic liver disease. Methods: Using the Weight and Lifestyle Instrument and clinical variables, collected on consecutive patients at the Penn State Hershey Medical Center a data base was created. Univariate and Multivariate analysis was performed. Results: A total of sixty-six patients did not have cirrhosis (non-cirrhosis) and 28 had cirrhosis. Obesity was similar between cirrhosis and non-cirrhosis. The time spent with BMI >30 was greater in cirrhosis then in non-cirrhosis (19.1 vs. 11.4 years). In the cirrhosis group 61% were obese for more than 15 years whereas in the non-cirrhosis group only 33% (P=0.01). The cirrhosis cases showed a pattern of lifetime gaining or shifting weights more often than non-cirrhosis (p=0.01), more often gained or lost a total of 80 pounds in their lifetime (p=0.005) and more often showed any form of weight shifting (p=0.02). In the final model the variables that predicted cirrhosis were platelet count, alcohol use of at least 20 grams daily and the time in years spent obese. Conclusion: These findings suggest that patients with liver disease should be counseled to remain lean (BMI <30). When patients with liver disease are overweight they should be counseled to lose weight and then maintain the lower weight. Patients with chronic liver disease need to be counseled against weight shifts.Table: Logistic regression model: independent predictors of cirrhosisTable: Odds of cirrhosis as time spent obese with chronic liver disease
Chronic liver disease
Univariate analysis
Liver disease
Cite
Citations (0)
Objective: To investigate the clinical characteristics of HCC with and without liver cirrhosis. Methods: Two hundreds and eighty-one patients with cirrhosis and 147 patients without cirrhosis were studied in terms of the clinical symptoms, and signs and laboratory parametes. Results: The development of HCC with cirrhosis were more insidiously and the prevalence of HbsAg in HCC patients with cirrhosis was significantly higher than in those without cirrhosis (85.1% vs 67.3%, P0.01), AFP and AST were elevated in more patients with cirrhosis than those without cirrhosis (P0.05). Conclusion: The HCC with cirrhosis is more significantly associated with HBV infection than those without cirrhosis. Monitoring serum AFP is useful for cancer detection in patients with cirrhosis, however for those patients without cirrhosis, early ultrasound is more important.
Cite
Citations (0)
Purpose To explore the relationship between serum NO and hypoxemia in patients with liver cirrhosis. Methods NO was measured in serum samples collected from 69 patients with liver cirrhosis and 20 healthy controls by colorometric assay. Results Higher serum level of NO were observed in patients with cirrhosis than that in normal controls(p0.01). Higher serum level of NO in cirrhosis patients with hypoxemia than that in cirrhosis patients without hypoxemia (p0.001). The increases of serum NO were inverse proportional to PaO_2(r=-0.99). The levels of serum NO were increased in accordance with the seventy of liver cirrhosis from Child-Pugh A→B→C (p0.05). PaO_2 decrased with the seventy of liver cirrhosis from child pugh A→B→C(p0.01). Conclusions The increase of serum NO may contribute to cirrhosis hypoxemia.
Cite
Citations (0)
Objective:To evaluate the clinical values of BuChE and PA and Alb Assay in diagnosis and prognosis of cirrhosis. Methods:To measure the activity of BuChE and the concentration of PA and Alb in serum of 197 patients with cirrhosis. The sensitivity and specificity and other performances of BuChE and PA and Alb assay for the detection of cirrhosis were evaluated by ROC curve analysis. Results: The activity of BuChE and the concentration of PAand Alb in serum of 197 patients with cirrhosis are lower than the control group(P0.01). There are singnificant difference between Child-Pough A and Child-Pough B Child-Pough C, each grade and the control group(P0.01). The activity of BuChE and concentration of PA are positive correlation to the concentration of Alb in the patients with cirrhosis. Conclusions: The serum BuChE and PA are better than Alb in the diagnosis and prognosis of cirrhosis.
Cite
Citations (0)