High-dose radiation therapy for inoperable non-small cell lung cancer without mediastinal involvement (clinical stage N0, N1).
Katumitu HayakawaNorio MitsuhashiMasaya FurutaYuji SaitoY. NakayamaSusumu KatanoMasafumi YamakawaIwao HashidaNiibe
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Objective To review the surgical result of 57 cases of bronchioloalveolar carcinoma (BAC) from 1966 to 1993. Methods 57 patients with BAC underwent surgical resection. There were 30 men and 27 women. The surgical procedures included 40 lobectomies,11 pneumonectomies and 3 wedge resections. According to UICC staging system,stage I in 31 cases, stage II in 12,stage IIIa in 11 and stage IIIb in 3. Results There was no operative death. The 1 ,3 ,5 year survival rates were 80 7%,54 6%and 36 5%, respectively. The 5 year survival rate for stage I (50%) and stage II (45 5%) was higher than that of stage III (0). Conclusions It may be concluded that the early diagnosis, early operation and the combination therapy are the key points for improving the survival rate of BAC.
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Objective To evaluate the efficacy of radiation therapy alone and the prognostic factors of endometrial carcinoma. Methods Fifty nine patients treated with radiation therapy alone in Cancer Hospital, CAMS from 1984 to 1999 were retrospectively studied, Stage Ⅰ 17, Stage Ⅱ 26, Stage Ⅲ 14 and Stage Ⅳ 2.The dose at point F was 35.0～59.0?Gy. The dose at point A was 34.5～58.8?Gy. 6 or 8 MV linear accelerator was used in the external radiation. Dose in the parametrium was 34.6～50.0?Gy. Results The overall 5 year survival rate was 64.3%,with 79.2% for Stage Ⅰ,75.3% for Stage Ⅱ, 31.4% for Stage Ⅲ and 0.0% for Stage Ⅳ,respectively. The 5 year survival rate was significantly lower in Stage Ⅲ than those in Stage Ⅰ and Ⅱ (P0.01). The 5 year survival rate for those with the high risk pathologic types such as clear cell cancer was lower than those with adenocarcinoma (P0.01). With regarding to the grade, those with Grade 3 gave worse results than those with Grade 1 or 2(P0.05). Conclusion Radiotherapy is considered as intent curative for endometrial carcinoma, especially for Stage Ⅰ and Ⅱ lesions. However, improvement of the treatment protocol is needed for those with advanced stages.
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Objective To evaluate radiotherapy results and prognostic factors of medium and advanced stage esophageal cancer.Methods A retrospective analysis was performed on 148 patients with medium and advanced stage esophageal carcinoma. All patients were only treated by radiotherapy,Kaplan-Meier method was used in survival analysis and Longrank method in comparison.Results The 1-,3-year survival rates were 64.2% and 20.9% respectively. The Karnofsky score,the length of lesion and the radiation response of tumor were significant prognostic factors ( P 0.01 ,0.01, 0.005). Conclusion The effect of radiation for esophageal carcinoma is exact. Some factors affect the prognosis.
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Objective: To analyze the treatment results of the stage Ⅲ non-small cell lung cancer patients with different treatment modality. Methods:To analyze retrospectively 212 stage Ⅲ non-small cell lung cancer patients initially treated in the Hunan Province Tumor Hospital from March,1997 to March,2001. Results:The survival rate of 1、3、5 years for the suargery,rachiation,chenotherapy groups were 41.9%(89/212),11.3%(24/212) and 6.6%(14/212) respectively.The five year survival rate were 10.3%(6/58)、5.8%(6/102) and 3.8% (2/52) for the patients with the first choice of treatment as surgery,radiotherapy and chemotherapy respectively.The difference among them was statically not siynificant. Conclusion: The surgery as the initial choice of treatment for the stage Ⅲ non-small cell lung cancer is better than the radiotherapy or chemotherapy.
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Objective To Study the correspondence strategies after operation in stage N 1 esophageal carcinoma.Methods From 1990 to 1997 in our hospital 179 Cases who proved N 1 stage after operation were retrospectively analyzed.Accordving different stage,compared different methods of therapy in the3 and 5 years overall survival rate.Results The 3 years and 5 years survial rates of the patients with ⅡB who underwent resection surgery followed by radiotherapy?Surgey followed by chemotherapy?bychemotherapy and radio therapy were 35%,25%;51 6%,35 3%;50%,25%;65 5%,41 4%;and the Ⅲ were 20%,6 7%;35 7%,7 1%;35 7%,14 3%;41 6%,29 1%?Conclusions Surgery follow by synthetic therape can increase the 3 and 5 years survival rate for stage N 1 patient with esophaseal carcinoma surgery follow by chemotherapy and radiotherapy is the best way.
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Objective:To evalute the clincal results and affec factors of radiotherapy for skin carcinoma.Methods:A retrospective study was done on 321 skin carcinoma patients treated from 1978 to 1992,all were pathologically proved.Results:The 5-year and 10-year survival rates were 66.7 %,51.1 % respectively (stage Ⅰ was 92.9 %,stage Ⅱ was 74.0 %,stage Ⅲ was 45.1 %,stage Ⅳ was 14.3 %).The survival rate of early stage was higher than the advanced stage (P0.05).The 5-year and 10-year survival rates of squamous cell carcinoma were 59.1 % and 42.6 %.The 5-year and 10-year survival rates of basal cell carcinoma were 80.1 % and 69.4 %,which were higher than squamous cell carcinoma.Conclusion:The clinical results of radiotherapy for skin carcinoma were ralated with stage and pathological types.
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In order to improve the survival-rates and study the long-term therapeutic effect of stage III lung cancer patients with different treatment modalities.From 1995 to 2004, 1921 patients of stage III lung cancer treated at our hospital were retrospectively analyzed to compare the long-term therapeutic effect of different treatment modalities. There were 606 cases in the combined therapy group (mainly surgical with combined treatment of chemotherapy & radiotherapy), 317 cases in the surgery alone group and 998 cases in the non-surgical group. The 1, 3, 5-year survival rates of these three groups were 66.0% (400/606) vs. 62.7% (199/317) vs. 51.2% (511/998), 32.34% (196/606) vs. 21.45% (68/317) vs. 8.15% (81/998), 19.31% (117/606) vs. 13.2% (42/317) vs. 4.2% (42/998) respectively. In comparison, 1, 3, 5-year survival rates of the combined therapy group was higher than the surgery alone and non-surgical groups; Significant differences in 1-year survival rates were found between the combined therapy group and the surgery alone group or the non-surgical group (P < 0.01) and significant differences in 3, 5-year survival rates among these three groups.The combined therapy of radical resection with chemotherapy and radiotherapy is the best treatment modality for stage III lung cancer.
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