Primary malignant lymphoma of the uterus. Case report.
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Objective To investigate the diagnosis and treatment of malignant lymphoma(ML)in maxilloface and neck.Methods From October of 1991 to October of 2000,68 patients(42 male and 26 female)with ML in maxilloface and neck admitted in our department.5 cases were Hodgkin's disease(HD)and 63 cases non-Hosgkin's lymphoma(NHL),41cases accepted systemic treatment,27 cases chemotherapy or radiotherapy only.Results The survial rate of 1,3 and 5 years for 68 patients was 44.12%,19.12% and 13.23%.Among survivals;most were Ⅰ and Ⅱ stage clinically,while in those dead patients,most belonged to Ⅲ and Ⅳ stage.Conclusions There was an significantly increasing trend for incidence of ML in maxilloface and neck and repeated biopsy should be carried out if unclear mass in these regions.Chemotherapy combined with radiotherapy and operation is still the effective therapeutic means.The clinical staging classification is worth the prognosis.
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子宮原発の悪性リンパ腫を経験したので報告する. 症例は70歳。主訴, 性器出血. 水腎症, LDH高値, 精神症状を認めた. 病理組織診ではLSG分類のnon-Hodgkin lymphoma diffuse, mediumsizedcell, B cell type, 子宮頸癌臨床進行期分類IV b期, Ann Arbor分類II E期であった. 子宮頸部細胞診では出血を背景にN/C比がきわめて大で, 裸核状にみえる円形の細胞が散在性に出現していた.
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We reported on two cases of Malignant Lymphoma in the spinal epidur al space. Case 1 was a 49-year-old man and case 2 was an 82-year-old wo man. Both cases had a neurological deficit without any evidence of systemic lymphoma. Laminectmy was performed in both cases and the tumors were removed and proved to be Malignant Lymphoma, the diffuse small cell type, pathologically. Postoperatively, radiotherapy and chemotherapy were administered and led to the improvement of the neurological symptoms.
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The uterus is rarely the initial site of malignant lymphoma. The purpose of this article is to present the MRI of malignant lymphoma of the uterus.Four cases with pathologically proven malignant lymphoma, in which the uterus was the only and the initial site of recognized visceral involvement, are presented; MRI was retrospectively evaluated.All the lesions exhibited homogeneous hypointense signal on T1-weighted imaging and relatively hyperintense signal on T2-weighted imaging. One case exhibited diffuse and uniform enlargement of the uterine corpus and cervix in the presence of preserved endometrium and cervical epithelium. With these findings, a prospective diagnosis of lymphoma was feasible. The three other cases exhibited MR findings that closely resembled those of carcinoma of the cervix. However, in one case, preserved cervical epithelium in the presence of extensive involvement of the cervical stroma may have been a clue to the diagnosis of malignant lymphoma. Involvement of the vagina (three cases) and the urinary bladder (two cases) was clearly identified on MRI.Lymphoma of the uterus exhibited various MR appearances; however, specific diagnosis might be feasible in limited cases. In addition, clear visualization of the extent of disease seen on MRI could contribute to clinical decisions about treatment.
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We report here a case of a 52-year-old female in whom immunohistological studies of the uterus established a diagnosis of extranodal marginal zone B-cell lymphoma. Malignant lymphoma arising from mucosa-associated lymphoid tissue (MALT) of uterus is extremely rare. Accurate histologic interpretation of uterine lymphoma is essential, as treatment options and prognosis vary based on the histological grade of such lymphomas. Patients with primary uterine lymphoma generally have intermediate or high-grade lymphoma and poorer prognosis.
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Primary uterine malignant lymphoma is frequently not prospectively diagnosed because of its rarity and nonspecific clinical findings. The authors present a case of primary uterine malignant lymphoma, in which ultrasonography, CT scan, and MRI revealed nonspecific findings, whereas Ga-67 scintigraphy showed intense uptake in the uterine mass that was highly suggestive of malignant lymphoma.
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The two major variants of malignant lymphoma are non-Hodgkin’s lymphomas and Hodgkin’s disease. More than 90% of all cases of non-Hodgkin’s lymphomas are of B-cell derivation. The malignant lymphoma localized in uterus is rare and characteristically symptom-free expressed, but when it does, the cervix is the presenting site three times more often than is the endometrium. We have experienced a case of malignant lymphoma originated from uterine cervix, so we report with a brief of literature.
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