[cDNA cloning of three new homeobox-containing genes of Anf class from human, chicken and newt].
0
Citation
0
Reference
10
Related Paper
Abstract:
On the basis of the analysis of cDNA of three new homeobox-containing genes from human, chicken, and newt, a new class of homeobox genes Anf is characterized homologous to the Xanf-1 gene from Xenopus laevis, earlier cloned by us. These genes may be largely involved in the specification of embryonic subdivisions in the forebrain region of the embryo. The homeodomains of the proteins encoded by these genes differ greatly in the primary structure from all previously described homeobox genes. The high variability of the homeodomain sequences of the proteins of this class imply their rapid evolution.Keywords:
Homeobox A1
Homeobox protein Nkx-2.5
HNF1B
EMX2
DLX5
Cloning (programming)
Forebrain
Cite
On the basis of the analysis of cDNA of three new homeobox-containing genes from human, chicken, and newt, a new class of homeobox genes Anf is characterized homologous to the Xanf-1 gene from Xenopus laevis, earlier cloned by us. These genes may be largely involved in the specification of embryonic subdivisions in the forebrain region of the embryo. The homeodomains of the proteins encoded by these genes differ greatly in the primary structure from all previously described homeobox genes. The high variability of the homeodomain sequences of the proteins of this class imply their rapid evolution.
Homeobox A1
Homeobox protein Nkx-2.5
HNF1B
EMX2
DLX5
Cloning (programming)
Forebrain
Cite
Citations (0)
Homeobox genes are a family of transcriptional regulato rs which contain a common 183-nucleotide sequence.Known as master control genes, they possess high conservation through evolution and play a crucial role in the development and differetiation of organisms.This article is about to discuss the expression of homeobox genes in glioma and the possible role of homebox genes i n oncogenesis,suggesting that homeobox genes may be useful in clinical diagnosis.
Homeobox A1
Homeobox protein Nkx-2.5
HNF1B
DLX5
CDX2
EMX2
Cite
Citations (0)
Journal Article Isolation and mapping of EVx1, a human homeobox gene homologus to even-skipped , localized at the 5′ end of Hox1 locus on chromosome 7 Get access Antonio Faiella, Antonio Faiella International Institute of Genetics and BiophysicaCNR, via Marconi, 10, 80215 Naples, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar Maurizio D'Esposito, Maurizio D'Esposito International Institute of Genetics and BiophysicaCNR, via Marconi, 10, 80215 Naples, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar Marco Rambaldi, Marco Rambaldi International Institute of Genetics and BiophysicaCNR, via Marconi, 10, 80215 Naples, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar Dario Acampora, Dario Acampora International Institute of Genetics and BiophysicaCNR, via Marconi, 10, 80215 Naples, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar Silvia Balsfiore, Silvia Balsfiore International Institute of Genetics and BiophysicaCNR, via Marconi, 10, 80215 Naples, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar Anna Stornaiuolo, Anna Stornaiuolo International Institute of Genetics and BiophysicaCNR, via Marconi, 10, 80215 Naples, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar Antonio Mallamaci, Antonio Mallamaci International Institute of Genetics and BiophysicaCNR, via Marconi, 10, 80215 Naples, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar Enrica Migliaccio, Enrica Migliaccio International Institute of Genetics and BiophysicaCNR, via Marconi, 10, 80215 Naples, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar Massimo Gulisano, Massimo Gulisano International Institute of Genetics and BiophysicaCNR, via Marconi, 10, 80215 Naples, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar Antonio Simeone, Antonio Simeone International Institute of Genetics and BiophysicaCNR, via Marconi, 10, 80215 Naples, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar ... Show more Edoardo Boncinelli Edoardo Boncinelli * International Institute of Genetics and BiophysicaCNR, via Marconi, 10, 80215 Naples, Italy * To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 19, Issue 23, 11 December 1991, Pages 6541–6545, https://doi.org/10.1093/nar/19.23.6541 Published: 11 December 1991 Article history Received: 06 August 1991 Revision received: 28 October 1991 Accepted: 28 October 1991 Published: 11 December 1991
HNF1B
Homeobox A1
Homeobox protein Nkx-2.5
Homology
EMX2
Cite
Citations (39)
Homeobox A1
HNF1B
EMX2
DLX5
Homeobox protein Nkx-2.5
CDX2
Cite
Citations (1)
Homeobox A1
HNF1B
Homeobox protein Nkx-2.5
EMX2
Cloning (programming)
Cite
Citations (27)
ABSTRACT We report the isolation of a new homeobox gene from Xenopus laevis genomic DNA. The homeodomain sequence is highly diverged from the prototype Antennapedia sequence, and contains a unique histidine residue in the helix that binds to DNA. The homeo-domain is followed by a 65 amino acid carboxy-terminal domain, the longest found to date in any vertebrate homeobox gene. We have raised specific antibodies against an X1Hbox 8-β-gal fusion protein to determine the spatial and temporal expression of this gene. The nuclear protein first appears in a narrow band of the endoderm at stage 33 and develops into expression within the epithelial cells of the pancreatic anlagen and duodenum. Expression within the pan-creatic epithelium persists into the adult frog. This unprecedented restriction to an anteroposterior band of the endoderm suggests that vertebrate homeobox genes might be involved in specifying positional information not only in the neuroectoderm and mesoderm, but also in the endoderm. Our data suggest that X1Hbox 8 may therefore represent the first member of a new class of position-dependent transcription factors affecting endodermal differentiation.
EMX2
CDX2
Homeobox A1
Antennapedia
Homeobox protein Nkx-2.5
DLX5
HNF1B
Cite
Citations (163)
Homeobox A1
HNF1B
CDX2
DLX5
Homeobox protein Nkx-2.5
Cite
Citations (0)
Homeobox A1
Ectopic expression
HNF1B
Homeobox protein Nkx-2.5
EMX2
CDX2
DLX5
Cell fate determination
Position (finance)
Cite
Citations (33)
Homeobox A1
Cloning (programming)
Developmental Biology
HNF1B
Homeobox protein Nkx-2.5
Cite
Citations (0)