Skalpell und CO2-Laser im Tierexperiment. Eine Vergleichsstudie an Impftumoren der Maus
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Lewis lung carcinoma
Antitumor activity of Hypsizigus marmoreus, an edible mashroom, was investigated by in vivo bioassay. The aqueous extract, hereinafter referred to as YH, was tested against syngeneic tumor, Lewis lung carcinoma. YH was found to give a significant increase in life span when assayed using a solid tumor, Lewis lung carcinoma, by intraperitoneal administration, but not as much by oral administration. It was also found that YH have an inhibitory activity of spontaneous tumor metastasis in mice bearing Lewis lung carcinoma by intraperitoneal administration. YH significantly decreased the number of metastasized nodules. It was suggested by Winn test that antitumor and antimetasatic activities shown by YH was effective in increasing activity on immunological by competent cells.
Lewis lung carcinoma
Edible mushroom
Intraperitoneal injection
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Lewis lung carcinoma was found to cause hypercalcemia in tumor-bearing mice. 24R,25(OH)2D3 (K-DR, prepared by Kureha Chemical Ind.) significantly prolonged the survival time of mice with Lewis lung carcinoma. K-DR exhibited an antimetastatic effect on Lewis lung carcinoma, and also had an analgesic effect in mice with Lewis lung carcinoma.
Lewis lung carcinoma
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Object To investigate the effects of tetramethylpyrazine (TMP) and Danshen (DS) on the growth and metastasis of Lewis lung carcinoma and tumor angiogenesis. Methods C 57BL mice with Lewis lung carcinoma were used in this study, which were injected respectively with TMP injection 50, 100, and 200 mg/(kg·d) and DS injection 5, 10, and 20 g/(kg·d), ip, for 21 days. Then the volume, weight, and numbers of the metastatic foci on lungs, tumor microvessel density (MVD) were determined, the expression of vascular endothelial growth factor (VEGF) of Lewis lung carcinoma was observed. Results TMP could remarkably reduce the volume, weight, and numbers of the metastatic foci, MVD, and the expression of VEGF of Lewis lung carcinoma. But DS did not show remarkably effect on Lewis lung carcinoma. Conclusion TMP can remarkably inhibit the growth and metastasis of Lewis lung carcinoma on mice, and its mechanism might be relative to inhibiting the expression of VEGF and angiogenesis. DS injection has no remarkably effect on Lewis lung carcinoma.
Lewis lung carcinoma
Tetramethylpyrazine
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Changes in functional activity of phagocytes from blood and peritoneal fluid, and production of NO compounds nitrates and nitrites, were studied in mouse models of Lewis carcinoma of the lung and Ehrlich carcinoma of the lung. Growth of metastatic Lewis carcinoma of the lung was shown to be associated with inhibition of endogenic production of NO compounds and decreased spontaneous release of free oxygen radicals by blood neutrophils. Total amount of nitric compounds in urine from Lewis carcinoma-bearing mice was 22.5-70.7% lower than in the control. Concentration of nitric compounds as calculated for nitrates in tumor tissue varied from (2.83-5.16) 106 mol/kg tissue and was poorly associated with Lewis carcinoma stage. Significant decrease in spontaneous chemiluminescence of blood neutrophils associated with tumor growth was 36.8-87% for Lewis carcinoma and 44.7% for Ehrlich carcinoma. Spontaneous chemiluminescence of peritoneal macrophages and monocytes was similar to that in the control, while phagocyte-dependent chemiluminescence of stimulated cells rose 2.2to 4.5-fold (p
Lewis lung carcinoma
Phagocyte
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Bimolane (AT1727), 1,2-bis (4-morphplinomethy1-3,5-dioxopiperazinyl)-ethane, is a derivative of ICRF154. It was first synthesized by Shanghai Institute of Materia Medica, Chinese Academy of Sciences. It slightly inhibited tumor growth and markedly inhibited the spontaneous pulmonary metastases of Lewis lung carcinoma in C57BL/6 mice. Adenosine cyclic-3’, 5’-monophosphate (cAMP) was assayed by Camp-dependent protein kinase binding assay in tumor tissue and plasma. Bimolane elevated moderately the Camp levels in primary tumor tissue of Lewis lung carcinoma. The cAMP level of plasma in normal C57BL/6 mice was not significantly different from that in C57BL/6 mice bearing Lewis lung carcinoma. Bimolane did not change the cAMP levels of plasma in C57BL/6 mice bearing Lewis ling carcinoma.
Lewis lung carcinoma
Cyclic adenosine monophosphate
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The antitumor activity of 1-alkyl carbamoyl derivatives of 5-fluorouracil against Lewis lung carcinoma and B16 melanoma by long-term oral administration was examined. The 1-hexyl and 1-phenethyl carbamoyl-5-fluorouracil derviatives were markedly active against early Lewis lung carcinoma among the derivatives tested. These compounds were not markedly active against advanced Lewis lung carcinoma but did show acceptable activity. Increases in lifespan in mice with early Lewis lung carcinoma at optimal doses of 1-hexyl and 1-phenethyl carbamoxyl-5-fluorouracil were 98% and 78% respectively. In advanced Lewis lung carcinoma, the 1-hexyl derivative was active by either intermittent or daily administration, but the 1-phenethyl derivative was active only by daily administration. Lung metastases were not inhibited by optimal doses of the 1-hexyl derivative but were completely inhibited by the 1-phenethyl derivative. The 1-hexyl derivative was also active against B16 melanoma and the increase in lifespan at optimal doses was 27%. As a result, 1-hexyl carbamoyl-5-fluorouracil was found to be the most active derivative against early Lewis lung carcinoma and B16 melanoma. However, 1-phenethyl carbamoyl-5-fluorouracil was the most active derivative against advanced Lewis lung carcinoma by daily administration and this compound completely inhibited lung metastases, while 5-fluorouracil and cyclophosphamide did not inhibit lung metastases.
Lewis lung carcinoma
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Oxalysine was found to be an antitumor antibiotic with a simple chemical structure very similar to lysine. In this paper, the antimetastatic action of oxalysine was studied and compared with ICRF-159. The Lewis lung carcinoma-bearing mice were killed at intervals during 10-21 d after sc implantation of tumor. The lungs from these mice were transplanted to other mice to examine the presence of tumor cells by bioassay. On d 21 after implantation of lung the tumor growth was found in 78% of the recipient mice. Oxylysine(160 mg/kg/d) was injected ip for 10 d to the Lewis lung carcinoma-bearing mice. The antimetastatic action could be detected when the treatment was started on the next day after implantation of tumor cells(P<0.05).When the drug was started on d 8 after implantation, antimetastatic action was more marked with 17% incidence of lung metastases(P<0.01). Hence oxalysine possesses a definite antimetastatic effect on Lewis lung carcinoma.
Lewis lung carcinoma
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Lewis lung carcinoma
Solid tumor
Lung tumor
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The antitumor effect of combination immunochemotherapy with Ge-132 and antitumor agent was studied using C57BL/6 mice bearing Lewis lung carcinoma (3LL). Ge-132 was administered orally at a daily dose of 100 mg/kg. Antitumor agents were administered intraperitoneally once a week. Initially, the effect of combination immunochemotherapy with Ge-132 and 5-fluorouracil (5-FU) was studied on 3LL local tumor growth, pulmonary metastases, survival, delayed type hypersensitivity (DTH) and body weight in tumor-bearing mice, and the following results were obtained: Inhibition of tumor growth in the combined group; Enhanced anti-metastatic effect; Prolonged survival time, and; Recovery of loss of both DTH and body weight as a result of combination therapy. These antitumor effects were also obtained by adoptive transfer of Ge-132-stimulated splenocytes in 5-FU-treated mice bearing 3LL. These results therefore suggest that the effects of Ge-132 were expressed through modification of immunocytes. Furthermore, Ge-132 enhanced the antitumor activity of bleomycin as well as that of 5-FU. These facts suggested that Ge-132 is useful for antitumor combination immunochemotherapy.
Lewis lung carcinoma
Splenocyte
Combination therapy
Adoptive immunotherapy
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Protocol for the preparation of tumor cells, subcutaneous injection of tumors and tumor extraction in mouse. This protocol is tuned for Lewis Lung Carcinoma (LLC) cells, but it can be used for the xenotransplantation of other types of tumor cells if the number of cells to be injected and the time that tumors should be allowed to grow are adjusted.
Lewis lung carcinoma
Xenotransplantation
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