Clinical value of serum procalcitonin in non-responding pneumonia
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Objective To investigate the applicative value of serum procalcitonin in non-responding community-acquired pneumonia.Methods Retrospectively analysis of non-responding pneumonia between January 1st 2009 and June 1st 2010.Results Causes of non-responding pneumonia were antibiotic failure(55.9%),mis-diagnosis(29.4%),and 5 cases with unidentified origin.Conclusion Serum procalcitonin is implicative of causes and therapy of non-responding pneumonia.Keywords:
Procalcitonin
Antibiotic Therapy
Value (mathematics)
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Objective: To discuss the clinical value of procalcitonin detection in infants and young children with serious pneumonia.Method: 75 cases of serious pneumonia,40 cases bacterial pneumonia,and 25 cases uiral pneumonia were enrolled into the study,and all the children were given PCT detection,and then it was contrasted between the three groups.Result: PCT of the bacterial pneumonia was significantly higher than viral pneumonia and mycoplasma pneumonia(P0.05);CRP of the viral pneumonia was significantly lower than of the bacterial pneumonia and the mycoplasma pneumonia(P0.01);According to the PCT values from high to low arrangement in the bacterial pneumonia,they were respectively severe pneumonia group,mild pneumonia group,and the control group(P0.05);PCT,WBC and CRP values in convalescence was significantly lower than before in the severe pneumonia group(P0.01).Conclusion: There is a positive correlation between PCT serum concentration and severity of the infants with pneumonia,PCT can be decreased as the disease controled,it can be used as areliable indicators in diagnosing,differential diagnosing,condition judgment and prognostic evaluation in infants and young children with severe pneumonia.
Procalcitonin
Mycoplasma pneumonia
Bacterial pneumonia
Convalescence
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Objective To evaluate the diagnosis value of procalcitonin(PCT)in bacterial pneumonia patients with renal transplantation.Methods To determine relative markers in 61 pneumonia inpatients with renal transplantation,PCT were determined by immunochromatografic test.Results The ROC curves showed that serum PCT≥0.5ng/ml could be used in diagnosis of bacterial pneumonia,and the serum PCT had the highest sensitivity(81%)and specificity(66%);the incident of patients positive PCT were higher in bacteria infection than the patients of negative PCT(P0.01).Conclusion Serum PCT≥0.5ng/ml could be implied the possibility of bacteria pneumonia,to be used 1as an indication of antibiotic.
Procalcitonin
Bacterial pneumonia
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Procalcitonin
Bacteremia
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Procalcitonin is used as a marker for sepsis but there is little known about the correlation of the procalcitonin elevation with the causative organism in sepsis. All patients aged 18 to 80 years who were admitted to the surgery service from June 2010 to May 2012 and who had a procalcitonin drawn were evaluated. Culture data were reviewed to determine the causative organism. Infections analyzed included pneumonia, urinary tract infection (UTI), bloodstream infection, and Clostridium difficile. Other parameters assessed included reason for admission, body mass index, pressor use, antibiotic duration, and disposition. Two hundred thirty-two patient records were reviewed. Patients without a known infection/source of sepsis had a mean procalcitonin of 3.95. Those with pneumonia had a procalcitonin of 20.59 ( P = 0.03). Those with a UTI had a mean procalcitonin of 66.84 ( P = 0.0005). Patients with a bloodstream infection had a mean procalcitonin of 33.30 ( P = 0.003). Those with C. difficile had a procalcitonin of 47.20 ( P = 0.004). When broken down by causative organisms, those with Gram-positive sepsis had a procalcitonin of 23.10 ( P = 0.02) compared with those with Gram-negative sepsis at 32.75 ( P = 0.02). Those with fungal infections had a procalcitonin of 42.90 ( P = 0.001). These data suggest that procalcitonin elevation can help guide treatment by indicating likely causative organism and infection type. These data may provide a good marker for initiation of antifungal therapy.
Procalcitonin
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Procalcitonin
Etiology
Atypical pneumonia
Bacterial pneumonia
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Because of the diverse etiologies of community-acquired pneumonia (CAP) and the limitations of current diagnostic modalities, serum procalcitonin levels have been proposed as a novel tool to guide antibiotic therapy. Outcome data from procalcitonin-guided therapy trials have shown similar mortality, but the essential question is whether the sensitivity and specificity of procalcitonin levels enable the practitioner to distinguish bacterial pneumonia, which requires antibiotic therapy, from viral pneumonia, which does not. In this meta-analysis of 12 studies in 2408 patients with CAP that included etiologic diagnoses and sufficient data to enable analysis, the sensitivity and specificity of serum procalcitonin were 0.55 (95% confidence interval [CI], .37-.71; I2 = 95.5%) and 0.76 (95% CI, .62-.86; I2 = 94.1%), respectively. Thus, a procalcitonin level is unlikely to provide reliable evidence either to mandate administration of antibiotics or to enable withholding such treatment in patients with CAP.
Procalcitonin
Bacterial pneumonia
Viral Pneumonia
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Objective To evaluate the value of serum procalcitonin( PCT) measurement on use of antibiotics of pneumonia in children. Methods 121 cases of pneumonia patients were randomly divided into two groups. Roche Cobas E411 chemiluminescence method was used to detect PCT. In experimental group,antibiotics was used while PCT ≥0. 25 μg·L-1,while PCT 0. 25 μg·L-1cases did not use antibiotics. In control group,antibiotics was used according to the conventional way. Efficacyes were compared after. Results Compared with the control group,the usage of antibiotic in Experimental group was lower significantly( P 0. 01). Conclusions There's a certain value of PCT measurement in distinguishing between bacterial and non-bacterial infection pneumonia and guiding the clinical use of antibiotics in children.
Procalcitonin
Bacterial pneumonia
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Objective To evaluate the function of PCT in identifying bacterial pneumonia.Methods To evaluate the value of PCT in etiology auxiliary diagnosis of pediatric pneumonia,we detected the serum level of PCT and compared CRP and WBC count on admission.Results The serum level of PCT rised mild-to-moderate in 34 cases bacterial pneumonia and the level was normal in 28 cases viral pneumonia and 25 cases mycoplasma or chlamydia pneumonia.The rising of CRP had an overlapping zone between bacterial pneumonia and viral pneumonia.The detection numerus of PCT in achiasmate control group was normal.Conclusion PCT is important index in earlier period identification of bacterial pneumonia.
Mycoplasma pneumonia
Bacterial pneumonia
Etiology
Viral Pneumonia
Clinical Significance
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Procalcitonin
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Community Acquired Pneumonia (CAP) is one of the commonest causes of patient's visit to the Emergency Room (ER). Hospitalisation of patient depends on severity of pneumonia. Various pneumonia severity assessment scores are available to predict mortality in community acquired pneumonia but these scores are not commonly used. Procalcitonin is a biomarker which is raised in bacterial infection and is easy and quick to measure. The aim of our study was to assess the ability of baseline serum procalcitonin level to predict mortality of community acquired bacterial pneumonia compared to PSI, CURB-65 and CRB-65 and its add-on value to the simple CRB-65 score.Fifty five patients admitted with Com-munity Acquired Bacterial Pneumonia were enrolled after taking informed consent and satisfying all inclusion and exclusion criteria. PSI, CURB -65, CRB-65 and PCT scores were determined on admission. PCT was measured by semi- quantitative assay; PCT Q. Primary outcome was 30 day mortality. Sensitivity, specificity, positive and negative predictive value of PCT for assessing mortality was calculated and compared to validated pneumonia severity scores; PSI, CURB-65 and CRB-65. We also assessed the ability of the combination of PCT to each of the scores to predict 30 day pneumonia specific mortality.In receiver operating characteristic analysis for mortality prediction, area under curve (95% CI) for PCT, PSI, CURB-65 and CRB-65 was 0.92 (0.85, 1.0), 0.88 (0.78, 0.98), 0.88 (0.76, 0.99), 0.9 (0.78, 1.0) respectively. Combination of PCT to each of the scores improved the prognostic ability to predict 30 day pneumonia specific mortality.Semi-quantitative PCT level at admission is an excellent test to predict the outcome of pneumonia. It predicts patients at low risk of mortality from community acquired bacterial pneumonia.
Procalcitonin
Pneumonia severity index
Bacterial pneumonia
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