Clinical Analysis of Simvastatin on the Advanced Aged Patients with Coronary Heart Disease
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Objective: To explore the effect of simvastatin on the advanced aged patients with coronary heart disease.Method: 93 cases of advanced aged patients with coronary heart disease were randomly divided into the group with amount of reinforcement(n = 46) and the group with amount of routine(n = 47).The group with amount of reinforcement were given simvastatin with the dose of 40mg / d,and the group with amount of routine were given simvastatin with the dose of 20mg / d.And then examined the blood of two groups and observed the adverse response.Result: After 8 weeks,The level of TC,TG and LDL-C in two groups were reduced(P0.01),The level of HDL-C in the two groups were improved significantly(P0.01).The rate up to the standard of the group with amount of reinforcement was 71.74%(33 /46),which was higher than that of the group with amount of routine,with the rate up to the standard of 42.55%(20 /47)(X 2 = 8.08,P0.01).The rate of the adverse response between two groups has no difference(X 2 = 0.11,P 0.05).Conclusion: The effect of simvastatin with 40mg / d on the advanced aged patients with coronary heart disease is effective and safe.Keywords:
Coronary disease
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Objective To observe the clinical effect of different doses of atorvastatin in the treatment with coronary heart disease. Method 60 patiens with oronary heart disease were randomly divided into the low dose group(20 mg/d) and high dose group(40 mg/d) 30 cases for each group, treated with atorvastatin for 16 weeks. The changes of blood lipid and safety in two groups were observed. Result After treatment, serum TC、TG and LDL-C levels of high dose group were significantly decreased, HDL-C levels of high dose group were significantly increased, showed significant differences between the two groups(P 0.05). The curative effect of high dose group was significantly increased, MACCE of high dose group was significantly decreased, showed significant differences between the two groups(P0.05). Conclusion 40 mg/d atorvastatin, safety and marked efficacy in treatment with coronary heart disease, is worth clinical promotion.
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Objective: To discuss the effects of rosuvastatin on hyperlipidemia blood lipids and high-sensitivity C- reactive protein of elderly patients with coronary heart disease. Methods: 68 patients with coronary heart disease and hyperlipidemia treated in my hospital from July 2012 to June 2013 were randomly divided into two groups, the control group(34 cases) was gave conventional treatment, on the basic of the control group, the observation group was gave rosuvastatin, with treattment period for 2 months. The level change of blood lipid and high-sensitivity C- reactive protein before and after treatment in the two groups were observed, and adverse reactions of two groups were Statistics during treatment. Results: The differences of TC, TG, LDL- C, HDL- C before treatment between the two groups was not significant, P0.05, and after treatment, TC, TG, LDL- C levels of two groups fallen, and HDL- C level raise, but TC, TG, LDL- C level after treatment in the observation group were significantly lower than that in the control group(P0.05), the level of HDL- C after treatment in the observation group were significantly higher than that in control group(P0.05). hs-CRP of treatment group before treatment was(3.86±1.12) mg/L, and hs-CRP of control group for(3.82 ±0.84) mg/L, there was no significant differences between the two groups(P 0.05), hs-CRP of treatment group after treatment was(2.57±0.66) mg/L, hs-CRP of control group for(3.23±0.66) mg/L, there was significant differences between the two groups(P 0.05). After treatment, patients in two groups appeared mild adverse symptoms, the incidence of adverse reactions in the treatment group was 8.82%, and the control group for 23.53%, with no significant differences between the two groups(x2= 0.497, P = 0.780 0.05). Conclusion: Rosuvastatin can effectively improve blood fat of coronary heart disease combined hyperlipidemia, and reduce high-sensitivity c-reactive protein, it is worth in the clinical treatment of coronary heart disease combined hyperlipidemia for more widely used.
Hyperlipidemia
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Objective To analyze the feasibility of the implementation of different doses of atorvastatin in the treatment of elderly patients with coronary heart disease. Methods A total of 80 cases admitted in our hospital were randomly divided into the control group and the observation group. The patients in group A were mainly given 40 mg atorvastatin for clinical treatment, and patients in group B were given 20 mg atorvastatin for treatment. And the treatment effect was observed in two groups. Results After treatment, TG, TC and LDL-cC levels of the two groups were associated with a certain degree of decline, the differences in TG, TC and LDL-cC levels of the two groups before and after treatment were statistically significant(both P0.05); after treatment, the elevated HDL-C level of group A was(1.24±0.39), significantly higher than that(1.12±0.41) of group B, the decreased level of TG, TC and LDL-cC of group A was(1.10±0.43),(3.30±0.65) and(1.06±0.49), respectively, significantly lower than(1.38±0.47),(4.42±0.64) and(1.65±0.42) of group B, respectively, the differences were statistically significant(all P0.05). The difference in the incidence of adverse reactions between the two groups was not statistically significant, P0.05. Conclusion The therapeutic effect of high dose atorvastatin for elderly coronary heart disease is better than that of low dose atorvastatin.
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Objective To summarize the pharmacological effects of atorvastatin,explore atorvastatin treatment efficacy and mechanism of coronary heart disease hyperlipidemia.Methods 120 patients were randomly divided into the observation group and the control group,the two groups were given the basis treatment,in the same period,the observation group plus the atorvastatin 20 mg/d,1 time/d.Over the same period,the control group plus simvastatin 20 mg/d,1/d,the course was 4 weeks.Determine the lipid levels and BNP concentration in the two groups of patients before and after treatment.Results After treatment,compared with before treatment,the TC,TG and LDL-C levels of the two groups were significantly lower,HDL-C was significantly higher,observation group were especially significantly(P0.05);After treatment,the differences of the TC,TG,LDL-C and HDL-C levels between the observation group and the control group were significant(P0.05).BNP levels significantly reduced after treatment in both groups,the difference was statistically significant(P0.05),compared with before treatment,and the BNP in the observation group decreased significantly than in the control group(P0.05).The incidence of adverse reactions in the observation group was 2/60(3.33%),3/60(5%)in the control group,the incidence of adverse reactions was no significant difference between the two groups(P 0.05).Conclusion Atorvastatin can be able to reduce blood lipid levels which is a safe and effective drug to treat coronary heart disease combined hyperlipidemia.
Hyperlipidemia
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Objective To evaluate the clinical efficacy and safety of different doses of atorvastatin on elderly patients with coronary heart disease combined with hyperlipidemia.Methods A total of 120 elderly patients with coronary heart disease and hyperlipidemia were in Shenzhen Futian Second People' s Hospital from May 2011 to Dec.2013 were included in the study,and they were randomly divided into low dose group and high dose group by coin toss method,60 cases in each group.Low dose group were given atorvastatin20 mg daily,high dosage group was given 40 mg daily,both taken 30 minutes after dinner,8 consecutive weeks as one course.The clinical efficacy,the incidence of cardiovascular events during treatment,and blood lipid changes etc of the two groups were compared.Results The total effective rate of the high dose group was 86.7%,of the low dose group was 70.0%,the difference was statistically significant(P 0.01).The levels of total cholesterol(TC),triglyceride(TG) and low density lipoprotein cholesterol(LDL-C) of both groups after 8 weeks of treatment were significantly decreased than before treatment,the differences were statistically significant(P 0.01),high density lipoprotein cholesterol(HDL-C) levels was significantly increased after the treatment(P 0.01).After 8 weeks of treatment,levels of TC,TG and HDL-C in th high dose group were significantly higher than the low dose group,while LDL-C level was significantly lower than the low dose group,the differences were statistically significant(P 0.01).During the treatment,the cardiovascular events rate in the high dose group were significantly lower than the low dose group,the difference was statistically significant(P 0.05).There were no obvious adverse reaction observed in both group,and all patients completed the treatment.Conclusion High dose atorvastatin in the treatment of elderly patients with coronary heart disease and hyperlipidemia has obvious effect,with high safety,thus has a high clinical value.
Hyperlipidemia
High-density lipoprotein
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Objective: To observe the therapeutic effect and the mechanism of different dose of atorvastatinin treatment of elderly patients with coronary heart disease and hyperlipidemia. Method: 120 cases were divided into observation group and control group, the two groups were treated for infrastructure, control with simvastatin atorvastatin group 60 mg/d on the basis of this, the 1 time/d. The observation group was given simvastatin and atorvastatin 40 mg/d, 1 time/d. To observe changes of blood lipid levels in the two groups. Result: After administration, blood lipid levels of the two groups significantly decreased, the observation group effect was more obvious, with a significant difference between the two groups(P0.05). The observation group's the incidence of adverse reactions was only 15%, which was higher than that of the observation group 66.66%(P0.05). Conclusion: 40 mg in doses of simvastatin is the routine clinical dose is safe and effective for the treatment of coronary heart disease in elderly patients with hyperlipidemia.
Hyperlipidemia
Therapeutic effect
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Objective To investigate the effect and security of statins on advanced age patients with acute coronary syndrome(ACS) after antihyperlipemia therapy.Methods One hundred and forty-three patients with ACS,more than 75 years old,were randomly divided into simvastatin group with 73 cases and Xuezhikang group with 70 cases.On the basis of standard therapy for coronary artery disease,the simvastatin group was given simvastatin 20 mg,once per day,while Xuezhikang group was given Xuezhikang 0.6 g,twice a day.All the patients were followed up for one year,the adverse effect and endpoint events were recorded.Results Before treatment,the difference of the total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C) and triacylglycerol(TG) was no statistical significance between the two groups(P0.05).After treatment,LDL-C in simvastatin group was lower than that in the Xuezhikang group,the difference was statistical significance(P0.05).The difference of TC,HDL-C and TG was no statistical significance between the two groups(P0.05).After treatment,the B-type natriuretic peptide(BNP) in the two groups all decreased(P0.05).There was no statistical significance in BNP before or after treatment between the two groups(P0.05).No case stopped drug treatment due to adverse reaction;the difference of the endpoint events one year after treatment between the two groups was no statistical difference(P0.05).Conclusion The effect of simvastatin and Xuezhikang on advanced age patients with ACS after antihyperlipemia therapy is effective and secure.And the effect of simvasatin is better than Xuezhikang.
Clinical endpoint
High-density lipoprotein
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Objective To evaluate the efficacy and safety of different doses of simvastatin in treatment of patients with coronary heart disease(CHD).Methods 114 patients with definite diagnosis of CHD were enrolled and divided into two groups treated with 20 mg (n=58) and 10 mg (n=56) simvastatin,once each night,respectively.The fasting serum levels of total cholesterol(TC),low-density lipoprotein cholesterol (LDL-C),high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) as well as functions of liver and kidney were determined before medication,6th,12th and 24th week after initial medication,respectively.Results The levels of TC and LDL-C were decreased significantly at 6th,12th and 24th week after initial medication (all P0.05),and at the same time,TC and LDL-C levels in 20 mg group were continuously lower than those in 10 mg group (all P0.05).The rate of reaching target level of TC or LDL-C(TC4.68 mmol/L,LDL-C 2.6 mmol/L) was higher in 20 mg group than in 10 mg group (78.2% vs 52.9%,P0.05).There were no statistical differences in adverse effects including abnormal liver enzyme between the two groups.Conclusion The simvastatin 20 mg in treatment of CHD is safe and more effective in lowering cholesterol,causing more CHD cases to reach the target level of cholesterol.
High-density lipoprotein
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To investigate whether patients, who are at risk of major acute coronary events, are safe to undergo and benefit from early intervention after using simvastatin.The study was a randomized, open, two-dosage-controlled trial to evaluate the safety and benefits of simvastatin administered to 197 patients (10 mg group, n = 98 and 20 mg group, n = 99), within 48 hours of hospitalization for a diagnosis of unstable angina or acute myocardial infarction (MI), with total cholesterol (TC) >/= 180 mg/dL or low-density lipoprotein cholesterol (LDL-C) >/= 100 mg/dL. Lipid levels were measured immediately, followed by the 3rd, 6th and 12th month after admission and all adverse events were recorded during follow-up.TC levels fell by 10.15% and 14.52% in the 10 mg and 20 mg groups (P < 0.05), and LDL-C levels fell 13.87% and 19.38% in the 10 mg and 20 mg groups, respectively (P < 0.01), 12 months after using simvastatin. The rates of achieving target TC reached 26.3% and 36.5% in the 10 mg and 20 mg groups (P < 0.01), and that of LDL-C reached 28.2% and 40.3% in the 10 mg and 20 mg groups, respectively (P < 0.01). There were higher rates of MI and re-hospitalization resulting from angina pectoris and revascularization in the 10 mg group compared with the 20 mg group.The results suggest that early intervention with the HMG-CoA reductase inhibitor, simvastatin, in acute coronary syndromes is possible and safe. It also indicates that the clinical dosage of simvastatin are relatively smaller than that for satisfactory lipid control in patients with acute coronary syndromes.
Unstable angina
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Objective To study the efficacy and safety of Taizhian in treatment of aged patients with primary hyperlipidemia.Methods Sixty patients with hyperlipidemia were divided into two groups.Taizhian and simvastatin of 10mg/d group have 30 patients (group A),simultaneously were given simvastatin 10mg before sleep and Taizhian three pills,po,tid for 8wk;30 patients (group B) were given simvastatim 20mg,before sleep for 8 wk.By using full-anutomatic biochemical analytic instrument to measure all lipidemia markers.Results In these two groups,the levels of TC,TG,LDL-C,AI decreased and HDL-C increased(P0 05 or 0 01).The levels of TC,TG and LDL-C were decreased with 27 48%,19 92%,25 90% respectively in Taizhian group,with 24 95%,17 11%,27 99% in simvastatin group.HDL-C increased in the two groups,these were 35 37% and 53 44% respectively.There were significantly difference in these two groups before and after treatment (P0 05),but not between them(P0 05).In the two groups the adverse reaction were mild.Conclustions Taizhian and simvastatin of 10mg/d are so effective in treatment hyperlipidemia as simvastatin of 20mg/d,while the former can decrease the adverse reaction.
Hyperlipidemia
Pill
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