Orientation and analysis of Yuyi hairless mice hairless gene mutation point
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Aim:To research the hairless gene mutation of Yuyi hairless mice.Methods:Partial hairless gene of Yuyi hairless mice and Kunming mice were cloned,sequenced,and compared with Mus musculus DNA.Results:The DNA fragment of Yuyi hairless mice contained 1 824 bp,that of Kunming mice contained 1 816 bp.There were 27 differences,including insertion,deletion,and point mutation.One nonsense mutation in exon 12 resulted in the introduction of a premature termination codon UGA.Conclusion:Hairless character is probably associated with the hairless gene mutation of Yuyi hairless mice.Keywords:
Hairless
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Nonsense
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Basis (linear algebra)
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Aim: To study the difference of hairless gene between Yuyi hairless mice and others species.Methods:RT-PCR technique was developed to clone and analyze the sequence of cDNA in hairless gene from Yuyi hairless mice,and to analyze comparatively biologic character of amino acid sequence encoding hairless gene in different species.Results: A full-length cDNA of Yuyi hairless mice was 4 014 bp,which has been accepted by GenBank(Accession Number: AY547390).The identities of nucleotide of hairless gene were 99.9%,99.7%,94.3%,81.7%,81.8% by homologous comparison among Yuyi hairless mice and other species,and those of amino acid sequences were 99.8%,99.7%,94.5%,79.8%,80.0%,respectively.Conclusion: The results suggest that the hairless gene is a highly-conserved gene and has higher homology among different mammalian taxons.
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Journal Article The Canadian hairless or Sphinx cat Get access ROY ROBINSON ROY ROBINSON St. Stephens Road NurseryEaling, London, W.13. England Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Heredity, Volume 64, Issue 1, January 1973, Pages 47–49, https://doi.org/10.1093/oxfordjournals.jhered.a108339 Published: 01 January 1973
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In 1924, Brooke obtained a pair of pink, smooth-skinned hairless mice from a man in North London, UK Mice were found near Maidenhead, England that people in the neighborhood called "rhinoceros mice" because they lacked hair and had a very wrinkled or "corrugated" skin. New mutations continue to arise spontaneously that have gross and histologic features similar to the hairless and rhino mutations. The utriculi develop in hairless homozygous mice; however, they are much smaller. The susceptibility of hairless mice on some genetic backgrounds to ultraviolet light-induced squamous cell carcinoma led to the speculation that a papillomavirus might exist in some strains as an endogenous cocarcinogen. Hairless mice express selective defects in T-cell functions, notably in T-helper cells and in macrophages. Hairless mice are smooth-skinned throughout life (with minor exceptions), compared to rhinos that develop prominent wrinkles. The rhino mutation has been used extensively to test efficacy of compounds that modulate the peculiar skin of this mouse.
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Hairless
Congenic
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Laboratory mouse
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Hairless
Nonsense mutation
Nonsense
Compound heterozygosity
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Objective To research the gene mutation of Yuyi hairless mice(for short: YYHL).Methods(The partial) hairless gene of YYHL,KM mice,Mus musculus(house mouse) were cloned,sequenced and compared respectively.Results The DNA fragment sequenced of YYHL mice contains 1746 bp,KM mice 1733bp.There were 32 differences in intron,including insertion,deletion and point mutation.Conclusion The hairless character is probably associated with the gene mutation of intron.
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Animal models carrying mutations in the hairless ( Hr) gene provide a rich resource for study of hair follicle biology. A spontaneous mouse mutant with a phenotype strikingly similar to rhino mutants of Hr arose spontaneously in the mouse facility at Oak Ridge National Laboratory. Sequence analysis of Hr in these mutants uncovered a nonsense mutation in exon 12, designated as Hr rh-R (rhino, Oak Ridge). The mutation led to significant reduction in Hr mRNA levels, predicted to be due to nonsense-mediated decay. Histological analysis indicated dilated hair follicle infundibula at 14 days of age that rapidly became filled with cornified material. Microarray analyses revealed that expression levels of many genes involved in keratinocyte differentiation, epidermal regeneration, and wound healing were significantly upregulated before morphological detection of the phenotype, suggesting their role in onset of the Hr rh-R phenotype. Identification of this new Hr allele and the underlying molecular alterations allows further understanding of the role of Hr in hair follicle biology.
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