The diagnostic value of B-type natriuretic peptide for left ventricular dysfunction in patients with coronary heart disease
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Objective To study the relationship between the plasma level of B-type natriuretic peptide(BNP) and the left ventricular function in patients with coronary heart disease. Methods BNP levels in plasma of 30 nomal controls and 69 patients with coronary heart disease were measured by chemilumino-immunoassay. The ventricular function was measured by NYHA and colored doppler echocardiography. Results The BNP concentrations in control group, ventricular function (Ⅰ-Ⅱ) group and ventricular function (Ⅲ-Ⅳ) group were (31.56±21.48) μg/L, (105.52±(91.77)) μg/L and (433.18±378.03) μg/L respectively. There was statistical significance among these groups(P(0.001). The levels of plasma BNP and the left ventricular ejective fraction (LVEF) had a significant negative correlation (r=(-0.70), P0.001). BNP levels of LVEF≤40% subgroup were significantly higher than those of LVEF40% subgroup (P0.01). Conclusions BNP level reflects the left ventricular function in patients with coronary heart disease. The determination of BNP has important value in the diagnosis of early ventricular dysfunction and the evaluation of the severity of cardiac failure.Keywords:
Ventricular Function
Brain natriuretic peptide
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Objective To investigate the correlation between the brain natriuretic peptide(BNP)level in serum and the severity of heart failure(HF)as well as the left ventricular function(LVF)in patients with HF.Methods 122 patients with HF before and after treatment and 20 control subjects were investigated by measuring the BNP level in serum,the left ventricular ejection fraction(LVEF)and the left ventricular end-diastolic diameter(LVEDD).Results The serum BNP level in patients with HF were markedly higher than those of control group(P0.01),and the increase of BNP level was closely correlated with the severity of NYHA function class.The BNP levels were correlated negatively with the LVEF(r=-0.34,P0.001).After treatment,the LVEDD in HF patients was obviously improved(P0.05),however,the BNP level in serum was markedly decreased after treatment.Conclusion The increase of BNP levels is closely correlated with the severityof HF,further more,the BNP levels also better reflected the LVF.
Brain natriuretic peptide
Positive correlation
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Objective:To demonstrate the relations of the plasma atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) concentration with the severity of heart failure, the underling heart disease and the left ventricular function in patients with heart failure.Method: ① Plasma ANP and BNP concentrations of patients with heart failure (n=75) and of normal controls (n=60) were measured with immunoradiometricassay immediately after admission. ② Hemodynamic parameters were measured with Swan Ganz catheter in 75 patients on the same time. ③ Left ventricular ejection fraction was measured with 99m Tc gated ventriculography.Result:① The plasma ANP and BNP concentrations of patients were significantly higher than those of normal controls (P 0.01 ). They also increased according to the severity of heart failure classified by Forrester′s classification. The plasma ANP and BNP concentrations also had a significant positive and negative correlations with PCWP(r= 0.64 , P 0.01 ) and CI (r= -0.76 , P 0.01 ) respectively. In spite of same degree of CI, PCWP, LVEF and plasma level of ANP, the plasma BNP level was significantly higher in MI group than those in VHD and DCM group (P 0.01 ). The plasma BNP concentration had a significant correlation (r= -0.78 , P 0.01 ) with left ventricular ejection fraction.Conclusion:The plasma levels of ANP and BNP increase significantly according to the severity of heart failure classified by Forrester′s classification. The plasma BNP concentration is elevated more markedly in heart failure patients caused by myocardial infarction. The plasma BNP concentration may be a biochemical parameter for evaluating the left ventricular function.
Brain natriuretic peptide
Atrial natriuretic peptide
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Objective To study the changes of serum BNP in elderly patients with heart failure,and to evaluate BNP in diagnosis and assessment of the value in the clinical application of senile heart failure.Methods Compared different NYHA heart function classification senile heart failure patients' serum BNP,cTn1,MYO laboratory indicators;and Studied the BNP and LVEDD,LVEF correlation.Results BNP in heart failure I group and the control group showed no significant difference(P 0.05),one of the other two groups were statistically different(P 0.05);cTn1,MYO,IV Ⅲ group,heart failure group compared with other groups was statistically significant(P 0.05);179 cases of BNP and LVEDD in elderly patients with heart failure,LVEF by the Spearman correlation analysis,LVEDD was positively correlated with BNP(r = 0.714,P 0.05),LVEF was negatively correlated with BNP(r =-0.639,P 0.05).Conclusion BNP has important clinical value in the early diagnosis of heart failure,worthy of clinical application.
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Objective To investigate the value of a B-type natriuretic peptide(BNP) rapid assay in the diagnosis of congestive heart failure(CHF). Methods Plasma BNP was measured in 174 patients with acute breathe difficulty. 103 patients among them were examined for left ventricular ejection fraction(LVEF) and left ventricular diastolic dimension (LVDD) by echocardiography. Results BNP levels of 140 patients with CHF and 34 patients with pulmonary breathe difficulty were 245 ng/L(5～4 500 ng/L) and (30.8±27.1) ng/L respectively. In patients with CHF, BNP levels were related with the New York Heart Association classification. The plasma BNP levels increased when LVEF reduced and LVDD dilated. The plasma BNP levels of NYHA class Ⅲ and Ⅳ were markedly higher than NYHA class Ⅰ and Ⅱ. Conclusions BNP can reflect the change of left ventricular function, and it might be useful for early diagnosis and prognosis of CHF.
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Objective To detect the content of plasma brain natriuretic peptide(BNP) in patients with coronary heart disease(CHD)and congestive heart failure(CHF),and to estimate the relationship between change of plasma BNP and CHF.Methods The content of plasma BNP in 140 patients with CHF and CHD was detected by immunologic fluorescence detector.Left ventricular ejection fraction(LVEF) and left ventricular end-diastolic dimension and(LVEDD) were detected by Doppler.The type of arhythmia was observed.The contrast analysis between the observation group and control group was carried out.Results The content of plasma BNP in observation group(865.6±590.9) pg·mL1 was obviously higher than this in control group(26.1±5.2) pg·mL-1(P0.01).With the aggravation of congestive heart failure,content of BNP in plasma rised up gradually in cardiac function II group and cardiac function III group or cardiac function IV group(P0.05,),LVEDD rised up gradually in cardiac function II group and cardiac function III group or cardiac function IV group(P0.05 or P0.01),LVEF and descended between cardiac function II group and cardiac function III group or cardiac function IV group(P0.01).Among 55 patients with cardiac function IV,there was significant deviation in BNP among the patients with sinus tachycardia,atrial fibrillation,intraventricular conduction blockade or third degree atrioventricular block(P0.01).Conclusion BNP in plasma may be reflect the grading and state of heart function in patients with congestive heart failure and coronary heart disease.
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Objective To investigate plasma brain natriuretic peptide(BNP) in heart failure patients,as well as the changes of the value of assessment of cardiac function.Methods Measured by Immune-fluorescence assay using 110 cases of patients with congestive heart failure(HF group) and 20 cases of healthy persons(control group) of plasma BNP concentration;use echocardiography measurement of left ventricular ejection fraction(LVEF).Results BNP in heart failure group was significantly higher than control group,the difference was statistically significant(P0.01),and the BNP level increased with the higher the group in NYHA classification of heart failure;BNP levels have a statistically significant difference(P0.01) in 4 different groups of cardiac function;Comparison with the pre-treatment,each group's concentration of BNP significantly reduced after one week treatment(P0.01);BNP level and LVEF was negatively correlated,and higher plasma BNP levels increase in mortality.Conclusion Monitoring BNP level can be used as the guidance indicators of diagnosis of heart failure,cardiac function assessment as well as the efficacy and prognosis.
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Objective:To investigate the value of B-type natriuretic peptide(BNP)level in diagnosis of heart failure(HF)and assessment of heart function. Methods:Thirty eight HF patients and 42 normal controls were determined left ventricular end-diastole dimension(LVEDD)by echocardiography,left ventricular ejection fraction(LVEF)by Simpson's formula.Venous blood BNP level was detected simultaneously.After treatment for 3-4 weeks,all of the HF patients were determined echocardiography and BNP level again.To observe the changes of all indexes,and the correlation between BNP level and LVEF,LVEDD.Results:The BNP level in the HF group was obviously higher than controls(P0.01).The BNP level was decreased in HF group after treatment(P0.01).BNP level had negative correlation with LVEF(=-0.72,P0.01)and positive correlation with LVEDD(=0.45,P0.01).Area under the ROC curve was 0.987 of BNP level for diagnosis of heart failure.Accepting the BNP standard as 96.35ng/L,the sensitivity,specificity and accuracy rating were 92.7%,94.1% and 91.4% respectivly.Conclusion:The BNP level is helpful to diagnose HF and assess heart function .
Brain natriuretic peptide
Venous blood
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Objective Plasma B-Type natriuretic peptide (BNP) was conducted asses the clinical value in the diagnosis of congestive heart failure and the relationship between BNP and ventriculai dysfunction. Methods We enrolled 127 patients with CHF. Plasma levels of B-Type natriuretic peptides (BNP) were measured and in these patients. Results The mean BNP concentration in blood samples obtained from patients with CHF was high gradually with the degree of NYHA from Ⅰ to Ⅳ. P0.01. The BNP level in patients with low left ventricular ejection fraction (LVEF) ≤ 0.05 were higher than in that with LVEF0.05, (P0.01). The BNP level in patients with high left ventricular end-diastolic diameter (LVEDD) ≥60mm was higher than in that with low LVEDD60mm, P0.01. Conclusions BNP plasma level is a good marker to left ventricular function.
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To investigate the correlation between brain natriuretic peptide (BNP) and the cardiac function in patients with heart failure(HF), the plasma level of BNP was determined by IRMA and the left cardiac function parameters were measured on echocardiogram in patients with different grade of HF. The results showed that the plasma level of BNP elevated with the worsening of heart failure (NYHA classification). The plasma levels of BNP were negatively correlated with left ventricular ejection fraction (LVEF) and left ventricular end-diastolic diameter (LVDd). The plasma level of BNP increases significantly along with the severity of HF classified by NYHA, and might be a biochemical parameter for evaluating the left ventricular function.
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Ventricular Function
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Brain natriuretic peptide
Ventricular Function
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