Studied on Rh blood group in Han nationality comparison with in Uigrus by blood group and serology method
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Objective:Studied on Rh blood group in Han nationality comparison with in Uigrus by blood group and serology method, and its significance was discussed.Methods:Rh antigens were detected with monoclonal and multiclonal D,C,c,E,e antibodies routinely. Negative results with routine serology were confirmed with IAT and Del types were detected with absorption/elution test.Results:The phenotypes out of 228 cases of unrelative Hans with RhD(-) were 130 ccee(57.02%),68 Ccee(29.82%) and 11 CCee(4.82%),without CCEe and CcEE phenotypes.The ccee(88.89%),Ccee(5.56%) and CCee(5.56%) phenotypes could be detected only out of 72 cases of Uigurs with RhD (-) in Xinjiang, China, and the ratio of Uigurs in ccee and Ccee phenotypes was higher than that of Hans(P0.005), but the ratio of CCee didn't posses statistical discrepancy(P0.05),compared to that of Hans.42 cases of the Del types(18.42%) were detected out of 228 unrelative Hans with RhD(-),however, none of the Del types was obtained out of 72 unrelative Uigurs. 6 cases of weak D belonged to RhD positive with weak agglutination,and 3 cases of Dtypes were classified to weak D,but the other Dtype showed negative with saline agglutination test and weak positive with IAT(belong to low graded weak D).Conclusion: Rh bood group of Uigurs on Xinjiang posses Oriental and Caucasian characteristics,which is a special Chinese nationality.Keywords:
Direct agglutination test
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This study was aimed to investigate the distribution of rare blood group in Zhejiang Han population. The H(-) (H system), GPA(-) and s(-) (MNS), Rhnull, Rhmod, D--, CCDEE, CCdEE (variations of Rh), GPC(-) (Gerbich), i(+) (I), Lu(b-) (Lutheran), Js(b-) and k(-) (Kell), Fy(a-) (Duffy), Ok(a-) (Ok), Di(b-) (Diego) phenotypes were screened by serological or molecular methods. Jk (a-b-) phenotype was detected by urea hemolytic test. The results showed that one Di (a+b-) individual was found in 1618 blood donors, three Fy (a-b+) individuals in 1007 donors and one CCdEE individual in 633 Rh negative donors. No Jk (a-b-), H(-), GPA(-), s(-), GPC(-), i(+) (adult), Lu(b-), k(-), Js(b-), Lu(b-) and Ok(a-) phenotypes were found in this large scale survey. It is concluded that Di (a+b-), Fy (a-b+), CCdEE phenotypes are confirmed in the blood donors and this study provides the distribution data of erythrocyte rare blood group in Zhejiang Han population.
Group B
Group A
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Rh34 antibodies were found to have a unique, previously only partly characterised, specificity within the Rh system. No evidence was seen that they were mixtures of hrB and Hr-like antibodies, or that hrB antibodies existed independently in the natural state. The term anti-hrB applied to Rh34 antibodies after they had been partially absorbed with R2R2 red cells. Four haplotypes not expressing Rh34 antigen were identified in the present study. The prefix * has been used to indicate them in this text. They were *r's (*dCces), *Ro (*Dce), *Rou (*D(uce)) and *R(od) (category III *Dce). Red cells with partially deleted or Rh(null) phenotypes were therefore not the sole red cells compatible with anti-Rh34. R2R2 red cells, which are known to carry weak Rh34 antigen, were incompatible. Twenty-two family and mother-child studies established that the Rh:-34 haplotypes were inherited as normal Mendelian dominant characters. Anti-Rh34 was capable of recognising RH 34 dosage and of excluding some men who had been wrongly accused in disputed paternity tests.
Red Cell
Mendelian inheritance
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Objective To explore individual expression difference of the M and N antigens on the red blood cell in Chinese Han population. Methods Fifty cases with MM,MN and NN phenotypes were chosen from 962 subjects of Chinese Han population, which have been identified by serology. The genotypes of the total 150 cases were confirmed by PCR-SSP, and the quantities of M and N antigens were determined by flow cytometry. Results In 962 Chinese Han individuals, the phenotype frequencies of MM, MN and NN were 24.01 %, 47.19 % and 28.79 %, respectively. The genotyping results of selected 150 samples detected by PCR-SSP were completely in accordance with the results detected by serology. The mean fluorescence intensity (MFI) of the M antigen was 432.78 on MM individuals and 425.06 on MN individuals. The M antigen in MM group was 2. 686 times the amount of which in MN group. On the other hand, MFI of the N antigen was 6.38 in NN group and 35.74 in MN group. The N antigen in NN group was 4. 268 times the amount of which in MN group. Conclusion There is a significant difference of expression amount of the M or N antigens among different blood groups in Chinese Han population.
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Chinese Han population; M,N antigens; Quantities; Difference; Flow cytometry
Chinese population
Han Chinese
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Abstracts: The frequency of subgroups of A was found to be varied among different populations. The occurrence of anti-A1 in some cases may lead to the problem in blood transfusion, if they were clinically significant. Objective:This study aimed to reveal the frequency of A subgroups in Thai blood donors. The occurrence and reactivity pattern of anti-A1 in A2, A2B and other A subgroup individuals were also studied. Materials and Methods: A total of 13,028 group A and 4,563 group AB were identified during July10, 2017 to August 5, 2017. The techniques used in this study included standardtube technique for agglutination and indirect antiglobulin test. Results:Among group A, the frequencies of A1, A2 and A3 were 13,000 (99.78%), 23(0.18%) and 5(0.04%),respectively. For group AB, the frequencies of A1B, A2B and A3B were 4,483 (98.25%), 59 (1.29%) and 21 (0.46%), respectively. Approximately, 21.30%, 4.63%,54.63% and 19.44% of total 108 A and AB subgroups were A2, A3, A2B and A3B, respectively. Anti-A1 detected at 4๐C was higher in number than at room temperature for A2 andA2B. The most common reactivity pattern that showed discrepancy in ABO typing was for A2B with weak anti-A1. All of anti-A1 found were of no clinical significance. Conclusion: The low frequency of A subgroup distribution in group A and group AB and the imbalance in A2 and A2B phenotype frequencies of ABO group in Thai blood donors were observed. In addition, anti-A1 in all subgroups of A in this study showed no clinical significance.บทคดยอ ความถของหมเลอดยอย A ของหม A และ AB มความหลากหลายในประชากรตางๆ และทสำคญคอ การพบวา ซรมของคนทมหมเลอดยอยบางรายม anti-A1ซงหากเปนชนดทมความสำคญทางคลนก อาจทำใหเกดปญหาในการรบโลหตได วตถประสงค เพอศกษาความถของหมยอยของ A ในผบรจาคโลหตคนไทย รวมทงศกษาปฏกรยาของ anti-A1 ในคนหมยอย A2, A2B และหมยอยชนดอนๆ วสดและวธการ ทำการศกษาระหวางวนท 10 กรกฎาคม - 5 สงหาคม พ.ศ. 2560 ไดตรวจตวอยางโลหตหม A จำนวน13,028 ตวอยาง และหม AB จำนวน 4,563 ตวอยาง โดยทดสอบปฏกรยาการจบกลม และ indirect antiglobulin test ดวยวธหลอดทดลอง ผลการศกษา ในกลมหม A ความถของ A1, A2 และ A3 เทากบ 13,000 (99.78%), 23 (0.18%) และ 5 (0.04%) ตามลำดบ สวน หม AB, มความถของ A1B, A2B และA3B เทากบ 4,483 (98.25%), 59 (1.29%) และ 21 (0.46%) ตามลำดบ anti-A1 ทตรวจไดทอณหภม 4๐C มจำนวนเพมขนจากทตรวจไดทอณหภมหอง สำหรบ A2 และA2B สวนปฏกรยาทพบบอยททำใหมความไมสอดคลองระหวาง เซลลและซรม ของหมโลหต ABO คอ กลม A2B ทม anti-A1 สำหรบ anti-A1 ทพบทงหมดในการศกษาน ทำปฏกรยาอยางออนและเปนชนดททำปฏกรยาไดดในอณหภมตำ ซงนบไดวาไมมความสำคญทางคลนก สรป ความถของหมยอยของ A ในหม A และ AB พบไดนอยมาก และพบความไมสมดลของ A2 และ A2B ของหมเลอด ABO นอกจากนยงพบวา anti-A1 ทตรวจไดในหมยอยทงหมดของ A ในการศกษาน ไมมความสำคญทางคลนก
Agglutination (biology)
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Agglutination (biology)
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Abstl:\ct Blood groups are genetically determined and exJ1ibit polymorphism, where different population groups have significant difference in the frequency of each blood group. This study was conducted to determine the frequency of ABO and Rhesus D blood groups among the blood dO:lors. A total number of 1306 blood donors attended the donor centre at SKIMS Medical College Hospital for blood donation in the year 2001-02. After each donation blood samples were collected in separate pilot hlbes for the estimation of ABO and Rhesus D blood groups. The frequency of O. A, Band AB, Rhesus D positive and Rhesus D negative were calculated separately. The highest liequency among the ABO blood groups was ofB (39.43%) and the lowest was of AB (8.11 %). Among the Rhesus D phenotypes. majority (93.33%) were Rhesus D positive. where as only 6.67% were Rhesus D negative. The prevalence of ABO/Rhesus D was calculated and the highest frequency was o1'B Rh-D positive (37.44%) followed by a Rh-D positive (28.9-+%). A Rh-D positive (19.21 %), AB Rh-D positive (7.73%), a Rh-D negative (2.90%), B Rh-D negati\'c (1.99%), A Rh-D negative (1.37%) and AB Rh-D negative (0.38%). This study showed that most common group was B followed by a & A and 93.33% were positive for Rh-D phenotype.
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A study of ABO blood group and Rh (D) factor, was carried out on 10478 cases. ‘0’ had the highest (35.13%) and blood group ‘AB’ the lowest (8.23%) frequency.Blood group 24.71% and 31.93%respectively. An overall 94.1 % of population was Rh (D)positive. Blood group A and B were A comparision of the ABO blood group and Rh(D) factor of the N.W.F.P., with that of Karachi population, shows that there has not been much difference between these two populations. (JPMA 35: 253, 1985).
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Abstract Approximately 300 different types of blood groups are identified so far, the ABO and Rh antigens are still the clinically most significant and genetically most polymorphic of all human blood group systems to date. A total of 200 unrelated individuals from Uttar Pradesh were studied for the phenotype and allele frequency distribution of ABO and Rh (D) blood groups. In total 200 samples analyzed, phenotype B blood type has the highest frequency 36.5% (n=73), followed by O (34.5%; n=69), A (20.5%; n=41) and AB (8.5%; n=17). The O, A and B frequencies were 0.5849, 0.1571 and 0.2580 respectively. The overall phenotypic frequencies of ABO blood groups were B>O>A>AB. The variation in phenotypic frequencies between male and female might be due to small sample size of male sample. The allelic frequency of Rh-negative was 0.2.
Uttar pradesh
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Objective To understand the distribution and frequency of Rho ( D ) -negative blood group phenotype of patients in Foshan Hospital of Traditional Chinese Medicine, Establish the blood group archives of Rh ( D )-negative patients and blood donors.Methods screening Rh( D ) Antigen by Johnson AutoVue Innova matching and automatic blood Analyzer, confirming Rh ( D ) -negative Antigen by indirect antihuman globulin test.And then filtering and classifing With the Rh factor c,C,E and e using test tube method.Results 43 cases of Rh ( D ) negative patients were tested In 16402,including type A of 11,type B of 11,type O of 19,type AB of 3; Rh phenotype were Ccdee 11,ccdee 30,CCdee 2.Conclusions the Rh( D ) negative rate was 0.26％,Conforms to China's Han population of Rh ( D ) -negative rates.It has a very important role in Mastering the Rh ( D ) -negative blood types distribution and frequency on Foshan crowd,establishing blood types archives of Rh( D )-negative,using emergency blood of rare blood type and reducing transfusion reaction of patients with immune.
Key words:
Rh (D) negative; phenotype; inpatient
Blood type (non-human)
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Haemolytic disease
Blood group antigens
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