Study on the prevalence and relation of hyperuricemia and metabolism syndrome in aged people
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Objective To analyze the prevalence of hyperuricemia and metabolism syndrome in the army retired officers in Sichuan and investigate the relativity of hyperuricemia with metabolism syndrome among these people.Methods The medical examination results of serum uric acid(SUA),cholesterol,triglycerides,blood sugar,blood pressure and body weight were analyzed statistically in 2582 army retired officers in Sichuan.Results Among 2785 participants,2582 male(92.7%)and 203 female(7.3%)were surveyed.The total morbidity rate of hyperuricemia and metabolic syndrome were 25.9% and 28.5%,respectively.Body mass index(BMI),blood pressure,triglyceride and fasting blood-glucose in the hyperuricemia group were significantly higher and the high density lipoprotein is lower than those in the normal group(P0.05).Conclusion The morbidity rate of hyperuricemia and metabolism syndrome in the retired officers of army in Sichuan is high.A clear relevance is shown between hyperuricemia and BMI,blood pressure,triglycerides and fasting blood-glucose.Keywords:
Metabolism disorder
Blood sugar
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Objective To investigate the prevalence of hyperuricemia and its risk factors in the adult population aged 35-70 years from 9 provinces.Methods 15 706 residents were recruited from the cross-sectional survey to determine the prevalence of hyperuricemia.Logistic regression model was used to investigate the association between uric acid levels and the various cardiovascular risk factors.Results The prevalence of hyperuricemia was 12.08% and was higher for men(14.59%)than women(10.21%).The increasing prevalence of hyperuricemia with age can be seen in female population(P0.05),but not in the male population(P0.05).The main concomitant disease of hyperuricemia were hyperlipemia(80.4%),then overweight and obesity(74.61%),elevated blood pressure(58.32%),abdomen obesity(45.47%),diabetes(11.80%).In a multivariate logistic regression model,age(OR=1.01,95% CI:1.01-1.02),male gender(OR=1.36,95% CI:1.21-1.53),obesity(OR=1.69,95% CI:1.52-1.88),hypertriglyceridemia(OR=4.28,95%CI:3.84-4.76),hypercholesteremia(OR=1.19,95% CI:1.06-1.33),elevated blood pressure(OR=1.17,95% CI:1.05-1.30),and drinking(OR=1.36,95% CI:1.19-1.56)were associated with increased risk of hyperuricemia.Conclusions Hypertriglycedemia,hypercholesteremia,male gender,elevated blood pressure,obesity and drinking are associated with increased risk of hyperuricemia.With the growing incidence of obesity and metabolic syndrome and the positive relationship between hyperuricemia and cardiovascular diseases,we need pay more attention to the control of hyperuricemia.
Abdominal obesity
Hyperlipidemia
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Objective To analyze the related risk factors for hyperuricemia by investigating its incidence in middle-aged and elderly retirees.Methods A total of 5412middle-aged and elderly retirees undergoing health check were included in this study.Hyperuricemia and its related risk factors were investigated with questionnaires.The patients underging physical examination and biochemical tests were divided into hyperuricemia group(n=1581)and normal uric acid group(n=3831).Influencing factors for hyperuricemia were analyzed by unconditional logistic regression analysis.Results The incidence of hyperuricemia was 29.21%in the 5412retirees undergoing physical examination and higher in males than in females(37.87%vs 24.98%,P=0.000).The incidence of overweight,abnormal blood glucose,renal insufficiency,hypercholesterolemia and hypertriglyceridemia,and the serum levels of blood urea nitrogen,AST,HDL-C and LDL-C were significantly higher in hyperuricemia group than in normal uric acid group(P0.05).Multivariate logistic regression analysis showed that sex,overweight,renal insufficiency,hypercholesterolemia,hypertriglyceridemia and elevated serum blood urea nitrogen level were the risk factors for hyperuricemia(P0.01).Conclusion The incidence of hyperuricemia is rather high in middle-aged and elderly retirees who should thus receive combined treatment.
Blood urea nitrogen
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Aim: The prevalence of hyperuricemia has been increased in recent years. The metabolic syndrome (MS), which consists of multiple interrelated conditions, increases the risk for atherosclerosis, cardiovascular diseases and type 2 diabetes, as well as mortality from cardiovascular diseases and all causes (1). Several studies have found an association between hyperuricemia and metabolic syndrome, moreover, several authors have suggested that serum uric acid (SUA) levels should be included in the definition of metabolic syndrome, as increased serum uric acid levels are independently associated with a higher risk of cardiovascular mortality. The aim of the present study was to analyze the association of hyperuricemia and metabolic syndrome and its several components in a Georgian population. The study include 83 patients with MS and hyperuricemia (51 males and 32 females), aged 61±9 years, who have addressed to The First University Clinic of Tbilisi State Medical University from January 2017 to December 2017. All patients had asymptomatic hyperuricemia. 55 patients without MS constituted the control group. Biochemical parameters: glucose, Total-Cholesterol, HDL-cholesterol, LDL-cholesterol, Triglycerides, Creatinine, Uric acid, C-reactive protein (CRP) were obtained with routine technique. Hyperuricemia was defined as SUA level ≥7.0 mg/dL in men and ≥6.0mg/dL in women. Waist circumference (cm) was measured and body mass index (BMI) was calculated (kg/m2).
Results: The result of our study shows, that patients with MS show higher risk of hyperuricemia than those without MS – 7.8 ±2.1 vs 5.9±1.3. Hyperuricemia was associated with a higher risk of presenting all the MS components, except hypertension and HDL.
Conclusion: In the present study carried out in a Georgian population, we have found an association between SUA levels and MS, especially with Glucose intolerance, abdominal obesity and hypertriglyceridemia.
Georgian
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Objective To study the relationship between hyperuricemia and metabolic synodrome among a population in Fuzhou city.Methods A cross-sectional study was used to investigate health examinees.SPSS 13.0 statistical software was used to analyze the data.Results The prevalence rates of hypercholesterolemia,hypertriglyceridemia,systolic pressure hypertension(SBP≥140 mmHg),diastolic pressure hypertension(DBP≥90 mmHg),obesity,high fasting glucose,low high density lipoprotein-cholesterol and metabolic syndrome were 23.81%,45.45%,15.81%,14.76%,44.66%,9.75%,6.06%,and 12.25%,respectively.Multiple variants regression analysis showed that there were positive correlations between prevalecne of hyperuricemia and hypercholesterolemia,hypertriglyceridimia,hypertension and obesity.There was a negative correlation between prevalence of hyperuricemia and sex(female).Conclusion Metabolic disorders are significantly related to hyperuricemia.
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Objective To investigate the incidence of hyperuricemia and related diseases in the old people in Qingdao.Methods The body height,body weight,and blood pressure were measured,and fasting serum uric acid,blood sugar,cholesterol and triacyglycerol were detected in 1 875 aged people who came to our hospital for medical examination.Results The detection rate of hyperuricemia was 23.7%,in which,male accounted for 27.5%,and female,16.1%(χ2=45.72,P0.01).In hyperuricemia group,the detection rates of dyslipidemia,hypertension,type 2 diabetes mellitus,coronary heart disease and obesity were notably higher than that in normouricemia group(χ2=61.39-178.52,P0.01).Conclusion Old people are a high-risk crowd of hyperlipemia.The changes of blood uric acid level should be watched closely.
Dyslipidemia
Blood sugar
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Dyslipidemia
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Objective:To investigate the blood uric acid level of Foshan's inhabitants, and to explore the correlation between hyperuricemia and boold biochemical examination,hypertention.Methods:All the clinical data of 13324 Foshan's health physical examination inhabitants were analysed. The health physical examination include to detect blood uric acid(BUA),blood urea nitrogen(BUN),serum creatinine(Scr), cholesterol(TC), triglycerides(TG), blood glucose (BG) and blood pressure(BP).Results:The mean of SUA was (349.8±97.6)μmol/L in male and (276.2±84.3)μmol/L in female(P0.05). The prevalence of hyperuricemia was 22.6% in male and 11.6% in female. The blood uric acid level and the prevalence of hyperuricemia in the mail was significantly higher than in the female(P0.05 and P0.001)).The prevalence of hyperuricemia among different age groups was significantly variation(P0.05).The prevalence of BUN, Scr, TC,TG,BS and BP increase was significantly higher in hyperuricemia group than in normal group(P0.05~0.01). Conclusion:The prevalence of hyperuricemia in Foshan was Higher than other districts in China except Taiwan. The prevalence of hyperuricemia was more high by age.There were high prevalence of renal function descent, hyperlipaemia, high blood glucose and hypertension in hyperuricemia group. They should be paid more attention by people extensively.
Blood urea nitrogen
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The relationship between metabolic syndrome (MetS) and hyperuricemia is not fully understood.To examine the association of hyperuricemia with MetS and the component of MetS that is mostly influenced by hyperuricemia among university workers.Anthropometric measurements, blood pressure, glucose, lipid profiles, renal function tests were measured in 1198 male and 1075 female (22-60 years old) workers on annual medical examination.Hyperuricemia was 3-fold higher in males (odds ratio, OR, 2.938, 95% confidence interval, CI, 1.909-4.522, P<0.01) than females after adjustment for age, body mass index (BMI) and renal function. Overall, individuals with hyperuricemia were 3.9-fold likely to have MetS OR, 3.903; CI (2.439-6.245), P<0.01, and dyslipidemia, 2.5 times (OR, 2.501; 95% CI, 1.776-3.521, P<0.01) after adjustment for age, BMI, sex and renal function. However, no associations were found in individuals with hypertension (OR, 1.427; 95% CI, 0.996-2.205, P=0.052) and hyperglycemia (OR, 1.476; 95% CI, 0.989-2.202, P=0.057). Administrative work positively associated (OR, 1.895; 95% CI, 1.202-2.925, P<0.05) with hyperuricemia in males and not females.Male workers with hyperuricemia, especially those working in administration were at risk of metabolic syndrome. It is important to screen, prevent and treat metabolic syndrome in individuals diagnosed with hyperuricemia at the workplace.
Dyslipidemia
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Dyslipidemia
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Objective To assess the prevalence of hyperuricemia and metabolic syndrome in Anhui Medical University,and to explore the relationship between hyperuricemia and metabolic syndrome.Methods By using cluster sampling method,a cross-sectional study of 1 162 people(582 men and 580 women) who participated in annual health examination in Anhui Medical University.Results The overall prevalence of the hyperuricemia was 13.7%,the condition was more common in men(16.5%) than in women(10.9%).Serum uric acid was statistically significantly correlated with body mass index(BMI),systolic and diastolic blood pressure,triglyceride and fasting plasma glucose(P0.05).People with serum uric acid concentrations upper quartile had a 3 times risks of MS(OR=3.00,95%CI=1.58-5.71),as compared with those who had concentrations lowest quartile.Conclusion Hyperuricemia is prevalent among people in Anhui Medical University.Hyperuricemia is positively associated with MS.Hyperuricemia has a great effect on metabolic syndrome.
Quartile
Cross-sectional study
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