Multiple primary carcinoma correlated with breast carcinoma
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Abstract:
Objective To study diagnosis, treatment and prognosis of multiple primary breast carcinoma. Methods The data of 6 patients with multiple primary carcinomas correlated with breast carcinoma were summarized. First and second primary breast carcinoma were treated by radical operation or with radiotherapy and chemotherapy. Result 3 patients (50% ) happened recurrences of carcinoma were followed up. Conclusion The causes of genesis of second primary carcinoma and recurrence of primary carcinoma were related with suppression of immunological function and also biological property of carcinoma.Keywords:
Breast carcinoma
Primary (astronomy)
Mammary carcinoma
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Objective:To observe the pathogensis,diagnosis,treatment and survival of the Nonbilharzial squamous cell carcinoma of the bladder.Method:The clinical data of 21 cases of nobilharzial squamous cell carcinoma of the bladder from April 2006 to April 2011 of our hospital were reviewed.Result:Among the 21 cases of bladder squamous cell carcinoma,16 patients were male and 5 were female,with a mean age of 62.8 years.Haematuria was the main clinical presentation,and irritative bladder symptoms and urinary tract infection were also seen in these patients.The 1,2 and 5-year survival rates for all patients were 55%,30% and 5% respectively,and the median survival time was 16.1 months.None of 21 patients had a superficial tumor(T1),4 patients had lymphnode metastases,and there is only one patient had distant metastase.Radical cystectomy could provide higher survival for patients than other therapies.Some patients were submitted to adjuvant chemotherapy and radiotherapy without any significant response.Evidence was provided that tumor stage and lymphnode status are the independent variables which affect survival probability.Conclusion:The prognosis of squamous cell carcinoma of bladder is relatively poor.It is very important for the patients to be early-diagnosed and early-treated.Radical cystectomy remains the mainstay of therapy for squamous cell carcinoma of the bladder.Locoregional recurrence is the primary cause of death in the majority of patients.Extensive surgery is recommended.And the role for neoadjuvant therapy needs further study.
Radical surgery
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Objective: To investigate the clinicopathological features and prognosis of primary squamous cell carcinoma of the breast. Methods: 2 cases of primary squamous cell carcinoma of the breast were analyzed. According to the TNM stage of breast cancer, the patients underwent hematectomy and stage IV and stage II. All the patients were treated with radiotherapy. Results: The age of onset was younger, ER / PR was negative, and 4 months after operation, no recurrence or distant metastasis was found. Conclusion: The clinical features of primary squamous cell carcinoma lack specificity, misdiagnosis, need to pay attention to differential diagnosis, standardized diagnosis and treatment strategy still need further study.
Breast carcinoma
Distant metastasis
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Objective
To investigate the clinical and pathologic features of squamous cell carcinoma of the breast.
Methods
The clinical and pathologic data of 23 squamous cell carcinoma of the breast patients admitted between 1984 and 2013 to Tianjin Medical University Cancer Hospital was analyzed retrospectively.
Results
Primary squamous cell carcinoma of the breast was a very rare tumor accounting for 0.06% of all breast cancers. All of the 23 patients were females aged 28 years to 87 years(median age 49 years). Average tumor size was 4.5 cm. 9 patients suffered from lymph node metastasis at admission (39.1%). The positive rates of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER-2) were 13.6% (3/23), 4.5%(1/23) and 0(0/20)respectively. With a follow-up time varying from 5 months to 36 months recurrence or metastasis were found in 8 patients, and another 1 patient was found having distant metastasis at admission. Lung metastasis (7/9) was most common.6 patients died.
Conclusions
Squamous cell carcinoma of the breast is highly invasive, with low rate of positive receptors and early distant metastasis or recurrence after operation, and poor patients' survival.
Key words:
Breast neoplasms; Pathology, clinical; Prognosis
Breast carcinoma
Primary tumor
Progesterone receptor
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Invasive lobular carcinoma
Lobular carcinoma
Breast carcinoma
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Metaplastic Carcinoma
Breast carcinoma
Neoadjuvant Therapy
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Breast metastases from solid non-breast tumor types are rare; however, they should be always considered in the differential diagnosis of a breast lesion owing to the associated poor patient prognosis and the requirement of different therapeutic strategies compared with those used to treat primary breast cancer. The aim of the current study was to summarize the characteristics of metastases to the breast in a southern Chinese population. The medical records and pathological sections of 22 patients with pathologically confirmed extra‑mammary metastases to the breast that presented to Sun Yat‑sen University Cancer Center between January 2000 and December 2015 were retrospectively reviewed. The median age of onset for breast metastasis was 43 years (range, 10‑62 years) and 19 (86.4%) patients had a known history of a primary tumor. The mean interval from diagnosis of the primary tumor to breast metastasis was 16.5 months (range, 6‑56 months). A unilateral (45.5% left, 36.4% right), upper outer quadrant (15/22, 68.2%) lesion of the breast was most frequently initially detected by self‑checking (63.6%). The most common origin of the primary tumor was the lung (22.7%). Nasopharyngeal carcinoma accounted for a high proportion of the metastases (18.2%). The median duration of survival from the time of diagnosis of a breast metastasis was 14 months (range, 2‑74 months). A total of 10 patients (45.5%) succumbed to the disease. The results also indicated that overall survival in patients that underwent surgery was improved compared with patients who did not undergo surgery. The results of the present study demonstrated that clinical history, imaging findings, pathology from the primary tumor and immunostaining were required in combination to establish an accurate diagnosis. Further investigation into the improvement of the prognosis of patients with metastases to the breast following surgery is required.
Primary tumor
Breast carcinoma
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Objective To retrospectively analyze the cli ni cal characteristics of 5 cases of primary squamous cell carcinoma of breast. Methods The 5 cases were classified into Stage Ⅰ(one case),Stage Ⅱ( t hree cases) and Stage Ⅲ(one case).All cases underwent modified radical resecti on,and after that,additional radiotherapy or chemotherapy was applied.R esults All cases received surgery,of which 4 received radiotherapy and 1 c hemotherapy.Conclusion Accurate classification and treatment of i nfiltrating cancers,especially the identification of metaplasia,can produce good prognosis.
Hemotherapy
Breast carcinoma
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Objective:To analyze the prognosis about primary squamous cell carcinoma of the thyroid and evaluate its prognostic factors.Methods:Related literatures published from 1981 to 2011 were searched on CNKI and Wanfang databases and detailed cases were reviewed.Using Log-rank test and COX regression model,univariate and multivariate survival analysis were made.Results:92 cases showed median survival of eight months.The 1-and 5-year survival rates are 40% and 16.5%,respectively.Local invasion and distant metastasis,surgical approaches,radiotherapy were statistically significant prognostic markers.Survival rate differences among patients without local invasion and distant metastasis who underwent different surgical approaches were significant.The additional radiotherapy was of benefit in patients with extracapsular extension into adjacent tissue.Conclusion:Primary squamous cell carcinoma of the thyroid had an extremely poor prognosis.Surgical treatment and radiotherapy after surgery were associated with prolonged survival.
Univariate analysis
Distant metastasis
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The present study aimed to elucidate the clinical characteristics of multiple primary carcinomas of the oral cavity. The clinical records of 1,024 patients who were treated during follow‑up for oral cancer at the Department of Stomatology, Henan Provincial People's Hospital, between March 2013 and December 2014 were retrospectively reviewed. The clinical characteristics of 961 patients who developed single primary oral squamous cell carcinoma (SCC) during follow‑up and 54 patients who subsequently developed multiple primary carcinomas in the oral cavity were compared. Multiple primary carcinomas exhibited a female predilection, were most prevalent in the gingiva, and tended to show earlier tumor and nodal stages, as compared with single primary carcinomas. The local recurrence rate was higher for multiple primary carcinomas, as compared with single primary carcinomas, and was demonstrated to increase with the number of multiple primary occurrences. The cumulative incidence rates for metachronous second primary carcinomas following the onset of the first carcinoma at 10 years was 8.0%. Recurrence of multiple primary carcinomas did not decrease the survival rates of the patients assessed in the present study. Furthermore, differences were detected in the clinical characteristics between patients with single oral SCC and those with multiple primary oral carcinomas. The results of the present study indicated that early diagnosis and treatment and close long‑term follow-up are required for patients with multiple primary oral carcinomas.
Primary tumor
Oral Cancers
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