Comparative study and clinical application of adenosine triphosphate stress and exercise stress myocardial perfusion imaging in diagnosis of coronary disease
0
Citation
0
Reference
20
Related Paper
Abstract:
Objective To explore diagnostic value of adenosine triphosphate stress myocardial perfusion imaging(ATP-MPI) to coronary artery disease(CAD).Methods ATP-MPI was made for 47 CAD patients and the contrast analysis was conducted among ATP-MPI,stress test myocardial perfusion imaging(STMPI) and coronary angiography(CAG).Results The detectable rate of ATP-MPI,ST-MPI and CAG were(78.7)%,(80.9)% and(85.1)%.There was no significant difference among them(χ~2=(0.638),P(0.05)).With CAG as the standard,the sensitivity and specificity of ATP-MPI and ST-MPI in CAD detection had no significance(P(0.05)).Conclusion Dignosis by ATP-MPI to CAD can replace ST-MPI as a routine examination.Keywords:
Adenosine triphosphate
Cite
Subclinical infection
Stress testing (software)
Cite
Citations (15)
Objective To assess the sensitivity,specificity and its clinical application of adenosine stress my- ocardial imaging on coronary artery disease(CAD).Methods 53 cases suspiciously diagnosed CAD were per- formed with Adenosine stress myocardial perfusion imaging after resting myocardial perfusion imaging in 24 hours,and the heart rate,blood pressure and clinical symptom during injecting adenosine were recorded.All pa- tients were performed with coronary angiography in the 2 weeks.Results The sensitivity,specificity and accu- racy of adenosine stress myocardial perfusion imaging for detection of CAD were 88.9%,70.6% ,83.0% respec- tively.The positive predictive value and negative predictive value was 86.5% and 75.0%.The sensitivity of sin- gle,two and three coronary artery disease was 78.6%,90% and 100% respectively.There is no severe aeeident during injecting adenosine.Conclusion Adenosine stress myocardial perfusion imaging has a higher sensitivity and specificity in diagnosis of CAD.It can be an important additional method of exercise stress myocardial perfu- sion imaging and deserve to utilize and to spread in the clinic practice.
Cite
Citations (0)
Objective
Stress 99mTc-MIBI myocardial perfusion imaging (MPI) be useful in evaluating myocardial ischaemia and judging coronary artery stenosis. The purpose of this study was to evaluate the sensitivity, specificity and accuracy of adenosine stress 99mTc-MIBI gated myocardial perfusion SPECT (G-MPI) for the diagnosis of coronary artery disease (CAD).Materials and methods
The subjects were 46 patients diagnosed or suspected CAD, including forty with angina, six with old myocardial infarction. Adenosine stress G-MPI were performed 90 min after injection of adenosine, and resting G-MPI performed in same day. All patients underwent coronary artery angiography within two weeks. Significant stenosis was defined when the coronary artery intraluminal stenosis ≥50%. Analyse the imaging and calculate the sensitivity, specificity and accuracy of adenosine stress G-MPI in diagnosing CAD and judging coronary artery stenosis. Do correlation analysis of left ventricular systolic function (left ventricular ejection fraction) between adenosine stress 99mTc-MIBI G-MPI and echocardiography.Results
The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of adenosine stress 99mTc-MIBI G-MPI for the diagnosis of CAD were 87.0%, 85.7%, 86.6%, 93.8%, and 72.7% respectively. The sensitivity, specificity and accuracy for the diagnosis of LAD, LCX and RCA stenosis were 88.2%, 90.9%, 88.9%; 78.6%, 83.3%, 80.0%; 90.5%, 81.8%, 87.5% respectively. LVEF-G-MPI correlated with LVEF-UCG significantly, with a correlation coefficient of 0.885 (R=0.0001).Conclusions
In Conclusion, stress adenosine 99mTc-MIBI G-MPI have provided better sensitivity, specificity and accuracy in the diagnosis of CAD, and is probably an accurate method for detecting coronary artery stenosis. It can be used in evaluating left ventricular function, especially for patients unsuited in the exercise MPI.Cite
Citations (0)
Objective: To evaluate the safety and diagnostic value of domestic-made adenosine stress test with myocardial perfusion imaging for coronary artery disease.Methods: A total of 51 patients were included in this study.Adenosine was infused.At the end of 3 minute of adenosine infusion.925MBq of 99mTc-MIBI was injected intravenously.SPECT myocardial imaging acquisition was obtained 1-1.5 hour after adenosine infusion.Hemodynamic chang and side effects caused by adenosine infusion were analyzed.By more than half a year follow-up to exclude or diagnosed coronary artery disease,and thus evaluation of adenosine stress myocardial perfusion imaging for diagnosing coronary artery disease.Results: The rate of side effects caused by domestic-made adenosine infusion was 86.3%(44 of 51 patients),but most of the side effects were mild and transient.The sensitivity,specificity,accuracy,positive predictive value and negative predictive value of adenosine myocardial perfusion imaging for detection of coronary artery disease was 90.9%,71.4%,88.2%,95.2%,55.6% respectively.Conclusion: Domestic-made adenosine can be safely applied in the stress test during myocardial perfusion imaging,and it is an sensitive method for detecting coronary artery disease.
Stress testing (software)
Cite
Citations (0)
Objective To evaluate the sensitivity,accuracy and specificity of adenosine stress myocardial perfusion tomographic imag-ing in the diagnosis of coronary artery disease(CAD).Methods A total of 132 patients with suspected coronary artery disease were included in the study.Adenosine was infused intravenously at a rate of 140 g/(kg·min)for 6 min.At the end of 3 min after adenosine infusion,925 MBq of 99mTc-MIBI was injected intravenously.In this process,the symptom,blood pressure and heart rate were recorded.SPECT myocardial imaging acquisition was obtained at hour 1.5 after adenosine infusion.If the imaging was abnormal,the resting myocardial perfusion imaging would be obtained at the next day.All patients underwent coronary angiography.Results Of 132 patients,87 patients showed the positive coronary angiography,and 45 negative;85 patients showed SPECT myocardial imaging positive,and 47 negative.The unanimous results detected by two methods were found in 108 patients.The false positive results of myocardial scintigraphy were found in 11 patients,and the false-negative in 13.The sensitivity,specificity and accuracy of adenosine myocardial perfusion tomographic imaging for the diagnosis of CAD were 85.1%(74/87),75.6%(34/45)and 81.8%(108/132).Conclusion Adenosine stress myocardial perfusion tomographic imaging is a useful non-interventional method for detecting coronary artery disease.
Spect imaging
Cite
Citations (0)
Objective To study the exercise test( TET) and to assess the diagnostic value of adenosine stress myocardial perfusion imaging for coronary heart disease( CHD). Methods Simultaneous TET、coronary artery angiography( CAG) and adenosine stress myocardial perfusion imaging examination of 139 cases suspected coronary heart disease were analyzed,and the test results to the CAG as the gold standard for diagnosis of coronary heart disease,compared with TET and adenosine stress myocardial perfusion imaging in the diagnosis of coronary heart disease in terms of sensitivity,accuracy and specificity. Results 139 patients with 84 cases after the CAG patients diagnosed with coronary heart disease. In the CAG data reference,TET compared with adenosine stress myocardial perfusion imaging,the accuracy of the adenosine stress myocardial perfusion imaging( 89. 29%) and specificity( 83. 64%) were superior to TET( accuracy of 69. 05%,specificity 63. 64%). In the diagnosis of severe coronary heart disease,the basic are the same,for virus infection aslar-pacific perspective of coronary heart disease,adenosine stress myocardial perfusion imaging( 60%) is higher than the accuracy of TET( 10%). Conclusion Adenosine stress myocardial perfusion imaging and TET as noninvasive examination method of the coronary heart disease are valuable to the diagnosis of coronary heart disease. The CAG as the control point,TET compared with adenosine stress myocardial perfusion imaging,adenosine stress myocardial perfusion imaging diagnostic performance better.
Stress testing (software)
Cite
Citations (0)
Objective
Stress 99mTc-MIBI myocardial perfusion imaging (MPI)) be useful in evaluating myocardial ischaemia and judging coronary artery stenosis. The purpose of this study was to evaluate the sensitivity, specificity and accuracy of adenosine stress 99mTc-MIBI gated myocardial perfusion SPECT (G-MPI) for the diagnosis of coronary artery disease (CAD).Materials and methods
The subjects were forty-six patients diagnosed or suspected CAD, including forty with angina, six with old myocardial infarction. Adenosine stress G-MPI were performed 90 min after injection of adenosine, and resting G-MPI performed in same day. All patients underwent coronary artery angiography within two weeks. Significant stenosis was defined when the coronary artery intraluminal stenosis ≥50%. Analyse the imaging and calculate the sensitivity, specificity and accuracy of adenosine stress G-MPI in diagnosing CAD and judging coronary artery stenosis. Do correlation analysis of left ventricular systolic function (left ventricular ejection fraction) between adenosine stress 99mTc-MIBI G-MPI and echocardiography.Results
The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of adenosine stress 99mTc-MIBI G-MPI for the diagnosis of CAD were 87.0%, 85.7%, 86.6%, 93.8%, and 72.7% respectively. The sensitivity, specificity and accuracy for the diagnosis of LAD, LCX and RCA stenosis were 88.2%, 90.9%, 88.9%; 78.6%, 83.3%, 80.0%; 90.5%, 81.8%, 87.5% respectively. LVEF-G-MPI correlated with LVEF-UCG significantly, with a correlation coefficient of 0.885 (R=0.0001).Conclusions
In Conclusion, stress adenosine 99mTc-MIBI G-MPI have provided better sensitivity, specificity and accuracy in the diagnosis of CAD, and is probably an accurate method for detecting coronary artery branch stenosis. It can be used in evaluating left ventricular function, especially for patients unsuited in the exercise MPI.Stress testing (software)
Cite
Citations (0)
Objective To explore the diagnostic value of drug stress nuclide myocardial perfusion imaging(MPI) to coronary heart disease(CHD).Methods The patients(n=88) with suspected CHD were simultaneously given coronary angiography(CAG) and dipyridamole or adenosine stress nuclide MPI,and then they were given retrospective analysis.The difference was less than 14 days between CAG date and MPI date.Taking CAG results as golden criterion of CHD diagnosis,the sensitivity and specificity of drug stress nuclide MPI were compared and analyzed.Results The sensitivity,specificity and accuracy of drug stress nuclide MPI were,respectively,91.4%,73.3% and 85.2% in the diagnosis of CHD.Among 5 false negative cases,4 with single vessel lesion,1 with double vessel lesion and all of them had good compensatory circulation.Among 8 false positive cases,3 with syndrome X and 4 with slow coronary flow.Conclusion Drug stress nuclide MPI is an effective pathway for non-invasive diagnosis of CHD and myocardial ischemia.Most of patients with false positive or false negative have corresponding pathophysiological bases of coronary artery or cardial myodium.
Dipyridamole
Cite
Citations (0)
Objective To explore the safety and diagnostic accuracy of adenosine 99 mTc-MIBI myocardial perfusion imaging in patients aged ≥65 years.Methods Ninety-two patients aged ≥65 years underwent adenosine 99 mTc-MIBI myocardial perfusion imaging and coronary angiography(CAG).Side effects caused by adenosine infusion were analyzed.The value of resting electrocardiograph(ECG),adenosine stress ECG and adenosine myocardial perfusion imaging in the diagnosis of coronary artery disease were compared.Results In the senile patients,85.9% had varied kinds of adverse reaction,while no serious adverse reaction occurred.In the 68 cases undergoing positive adenosine 99 m Tc-MIBI myocardial perfusion imaging,46 patients presented with severes coronary artery stenosis,16 with coronary slow flow(CSF)and 6 cases with normal coronary flow confirmed by coronary angiography.The sensitivity of adenosine myocardial perfusion imaging for the diagnosis of coronary stenosis and CSF were 95.8% and 84.2%.The specificity of adenosine myocardial perfusion imaging for diagnosing coronary artery disease was 76.0%.The sensitivity of adenosine myocardial perfusion imaging was significantly higher than that of adenosine stress ECG and resting ECG(P0.05).Conclusions Adenosine 99 mTc-MIBI myocardial perfusion imaging is a safe and useful noninterventional method for detecting coronary artery disease in patients aged ≥65 years.
Fractional Flow Reserve
Cite
Citations (0)
目的 比较运动负荷早期(15～20min)99Tcm-甲氧基异丁基异腈(MIBI)门控心肌显像(G-MPI)和非门控心肌显像(NG-MPI)诊断冠心病(CAD)严重三支病变(狭窄≥70%)的价值.方法以冠状动脉(简称冠脉)造影(CAG)所示冠脉直径狭窄≥70%为严重CAD诊断标准,将同期做运动负荷99Tcm-MIBISPECTG-MPI和CAG的215例患者分为CAD三支病变组(A组)与CAD非三支病变组(B组).结果G-MPI与NG-MPI诊断严重CAD的灵敏度分别为95.3%(143/150例)和90.7%(136/150例,χ2=2.509,P=0.113),特异性分别为80.0%(52/65例)和72.3%(47/65例,χ2=1.059,P=0.303);诊断CAD三支病变的灵敏度分别为100%(51/51例)和92.2%(47/51例),前者更好,且两者差异有显著性(χ2=4.163,P=0.041).结论在诊断临床高危CAD严重三支病变时,G-MPI比NG-MPI更有价值。
Myocardial imaging
Cite
Citations (0)