Study of normal cerebral white matter in children from birth to 2 years with diffusion tensor imaging
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Splenium
Optic radiation
Occipital lobe
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Objective To analyse white matter anisotropy(FA)values in patients with mild cognitive impairment(MCI),and explore the FA value for the diagnosis of mild cognitive impairment.Methods Magnetic resonance diffusion tensor imaging(DTI)in 18 patients with MCI(MCI group)and 18 age-matched healthy volunteers(.control group)were analyzed,head DTI scans were performed with GE Signa Excite 1.5 T MR system,2 groups were measured bilateral temporal lobe white matter,lateral front corner narration quality,medial frontal and parietal subcortical while matter FA values,and compare the measurement results.Results Bilateral anterior horn of the lateral ventricle MCI group narration quality,right temporal lobe and right parietal white matter inside the subcortical white matter FA values lower than the healthy control group(P0.05)The bilateral medial frontal subcortical white matter,bilateral posterior horn of the lateral ventricle narration nature,left temporal lobe white matter,left parietal subcortical white matter and media]corpus callosum and the press section FA values between the two groups showed no significant difference(P0.05).Conclusion Bilateral anterior horn of the lateral ventricle quality narration,right temporal lobe and right parietal white matter inside the subcortical white matter FA values decrease as early diagnosis of MCI imaging indicator for early intervention and improve the patient's quality of life is important.
Parietal lobe
Frontal lobe
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Objective To study the normal changes in brain white matter during childhood by analyzing the anisotropy of different regions and different age groups with diffusion tensor imaging (DTI). Methods DTI was performed in 89 children (age range from 2 days to 18 years) without brain abnormalities, and the data measured in fractional anisotropy(FA) maps were analyzed statistically. Children less than 6 months were ranged to group 1, 6-12 months to group 2, 1-3 years to group 3, 3-5 years to group 4, 5-8 years to group 5, 8-12 years to group 6, 12-18 years to group 7. Results (1) There were significant differences in anisotropy (FA values) among different regions of white matter in brain In group 7, the FA value of corpus callosum was 0.826±0.039, middle cerebellar peduncle 0.678±0.043, frontal white matter 0.489±0.033. (2) The anisotropy among different age group was statistically different, P0.05. (3) The anisotropy of white matter increased with the increasing of age, and FA values showed positively exponentially correlations with age. Conclusion DTI shows the structure of white matters in vivo, with which normal changes in brain during childhood can be evaluated.
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Diffusion-tensor imaging can be used to observe the microstructure of brain tissue. Fractional sotropy reflects the integrity of white matter fibers. Fractional anisotropy of a young adult brain is low in gray matter, high in white matter, and highest in the splenium of the corpus callosum. Thus, we selected the anterior and posterior limbs of the internal capsule, head of the caudate nucleus, semioval center, thalamus, and corpus callosum (splenium and genu) as regions of interest when using diffusion-tensor imaging to observe fractional anisotropy of major white matter fiber tracts and the deep gray matter of healthy rhesus monkeys aged 4-8 years. Results showed no laterality ferences in fractional anisotropy values. Fractional anisotropy values were low in the head of date nucleus and thalamus in gray matter. Fractional anisotropy values were highest in the splenium of corpus callosum in the white matter, followed by genu of the corpus callosum and the posterior limb of the internal capsule. Fractional anisotropy values were lowest in the semioval center and posterior limb of internal capsule. These results suggest that fractional anisotropy values in major white matter fibers and the deep gray matter of 4-8-year-old rhesus monkeys are similar to those of healthy young people.
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Purpose: To reveal the cerebral white matter diffusion anisotropy changes during the normal aging by diffusion tensor imaging(DTI).Methods: Ninety-eight healthy volunteers across the adult age span were recruited for this study.They were divided into three age groups: young group(20-39 years old),middle group(40-59 years old) and old group(60 years or older).All subjects were evaluated with DTI at 3.0T MRI.Fractional anisotropy(FA) values of the frontal white matter,centrum semiovale,internal capsules,thalami,nucleus lentiformis,caudate nucleus and cerebral peduncle in each hemisphere and the genus and splenium of corpus callosum were determined by region-of-interest analysis.Results: The corpus callosum had the highest FA value,and the basal ganglia and the thalami had the lowest.FA values in the genus of corpus callosum,frontal WM and centrum semiovale in old group were significantly lower than those in the middle age group and the young group.There was significant age-related decline of FA values in frontal WM,the genus of corpus callosum,centrum semiovale and the thalami.In contrast,the FA values of splenium of corpus callosum,the internal capsules,thalami,nucleus lentiformis,caudate nucleus and cerebral peduncle were relatively unchanged.Conclusion: Different brain tissue has different sensitivity to aging,and the ventral structures are especially vulnerable to aging.This normative data may be valuable in diagnosis of neurodegenerative diseases.
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Caudate nucleus
Putamen
Cerebral peduncle
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Objective:To investigate changes of the cerebral white matter anisotropy in the depressives by using diffusion tensor MR imaging.Methods:9 depressives were studied using MR diffusion tensor imaging compared with 10 healthy adults.The fractional anisotropy(FA) values were measured.The ROIs were put in the frontal,temporal,occipital lobe and callosum respectively.Results:Comparing with healthy adult,significant difference of the FA values of white matter was found in bilateral frontal lobe,temporal lobe and splenium of corpus callosum in the depressives.Conclusion:There is a tenuous FA value reduction in the depresives compared with healthy adult,and the FA values in the left frontal lobe and temporal lobe are different from the right ones.
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Frontal lobe
Occipital lobe
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To investigate the correlation between cerebral white matter fraction anisotropy (FA) in normal human adults using the diffusion tensor magnetic resonance (MR) imaging (DTI).Forty-five adults with normal cerebral white matter MRI findings in 3 age groups (n=15), namely 25 approximately 35 years (young), 45 approximately 55 years (middle-aged) and 65 years or above (elderly), underwent conventional MRI and diffusion tensor MR imaging. FA was measured in different regions of interest (ROIs) including the genu and splenium of the corpus callosum, posterior limb and anterior limb of the internal capsule, centrum semiovale, frontal white matter, thalamus and head of the caudate nucleus.The FA values of the corresponding regions were similar between the left and right hemispheres. The FA value in the genu of the corpus callosum, centrum semiovale and the frontal white matter decreased with age, showing significant differences between the 3 age groups (P<0.05). The FA value in the splenium of the corpus callosum decreased significantly with age, with significant differences between the elderly and young groups and between the elderly and middle-aged groups (P<0.05). The values in the posterior limb and anterior limb of the internal capsule also decreased significantly with age as shown by comparison between the elderly and young groups (P<0.05). No significant difference was found in the FA value of the thalamus and head of the caudate nucleus between the three groups (P>0.05).The FA values decrease with age, especially in the genu of corpus callosum, centrum semiovale and frontal white matter. The patient's age and age-related white matter degradation must be considered in DTI-based diagnosis of cerebral diseases.
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Caudate nucleus
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Objective:To study the diffusion anisotropic features of different tissues and structures of normal young adults brain by using magnetic resonance diffusion tensor imaging.Methods:Forty normal young adults were examined by magnetic resonance diffusion tensor imaging (DTI).The signal features of different brain structures on both apparent diffusion coefficient (ADC) and fractional anisotropy (FA) maps were analyzed.The ADC and FA values were measured,and the results were analyzed statistically.Results:There was no significant difference between gray matter and white matter in ADC values (807.78±90.29-6 mm2/s and 775.79±115.31×10-6 mm2/s,P=0.098).FA values were significantly different from region to region in the brain.FA values of the white matter were much larger than those of gray matter and cerebrospinal fluid (P0.05).FA values were significantly different among different parts of white matter (P0.05).Splenium of corpus callosum had the highest FA values (0.73±0.09),followed by knee of corpus callosum and posterior limb of internal capsule (0.68±0.05 and 0.67±0.06,respectively).Semi-oval center and occipital forceps white matter had the lowest values (0.53±0.09 and 0.53±0.09,respectively).Dorsal thalamus had the highest FA values in gray matters (0.31±0.04).Conclusion:FA value can precisely quantitatively determine the diffusion anisotropic properties of different intracerebral tissues of normal young adults,and DTI could well display intracerebral neurofibers.
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Objective: Diffusion tensor imaging (DTI) was used to analyze the changes of white matter fiber FA in patients with schizophrenia of different ages and genders, and to explore the reference of clinical imaging. Methods: Retrospective analysis of the clinical diagnosis of schizophrenia patients and healthy subjects in all 50 cases, were given routine examination of brain MRI parallel diffusion tensor imaging, comparison of different age and gender in different parts of the brain white matter changes of FA value. Results : (1) the FA values of white matter in different age groups were different between the patients and the normal group ( P < 0.05). The normal group right superior frontal gyrus, left parietal lobe and left anterior cingulate gyrus of the cerebral white matter fiber FA value increased gradually before the age of 30, at the age of 30 and reached the peak gradually decreased after 30 years old. The left frontal gyrus and corpus callosum in patients with group pressure (after) of cerebral white matter fiber FA value increased gradually before the age of 30, at the age of 30 and reached the peak gradually decreased after 30 years old. (2) the FA values of white matter in different parts of male and female patients were different (P < 0.05). The white matter fiber FA in the left anterior capsule of the normal group was higher in males than in females. The FA value of bilateral occipital white matter in male patients was lower than that in female; the FA values of the central white matter in the left and right sides of the brain stem were higher in males than in females. Conclusion : the changes of FA value in the white matter of some parts of the brain in the normal group and the patient group are influenced by age and sex.
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