Relationship between asthma and body mass index
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Objective:To explore the relation of the body mass index(BMI) with asthma and its severity in adults.Methods:A total of 83 patients with asthma and 32 control subjects were studied.We analysed the relation of BMI and asthma,the relation of BMI and severity of asthma in all patients,respectively.Results:BMI was higher in asthma groups than in controls(25.19±4.09 vs 22.58±3.32).The values of BMI was(23.24±4.25) kg/m~2 in mild persistent group,(25.25±3.25) kg/m~2 in moderate persistent group,(27.52±4.74) kg/m~2 in severe persistent group.There were significant differences between asthma patients group and the controls,as well as between the mild, moderate and severe persistent patients.Conclusion:BMI is related to asthma and the severity of asthma.Cite
Childhood asthma and obesity are significant public health problems. Most prospective studies suggest that obesity increases the risk of asthma. But, some authors did not found this association. In this study the association between asthma and body mass index (BMI) was investigated. This case-control study was conducted on 200 asthmatic children aged 6-15 years and 200 children without asthma. The criteria for asthma diagnosis and its classification were on the basis of National Asthma Education and Prevention Program (NAEPP). BMI of patients and controls were also measured and BMI grater than 85% and 95% were defined as overweight and obese respectively. The data was analyzed by SPSS software. The BMI among the asthmatic children (17.9 kg/m2) was higher than the BMI among the non-asthmatics (16.5 kg/m2), P=0.0001. This relationship was significant in both males and females. 18% of asthmatic children were classified as overweight and 13.5% of them were obese versus 7.5% and 6% respectively in non asthmatics (P=0.0001). However, there was no significant relationship between severity, duration of asthma, kind of medication and BMI in children with asthma (P>0.05). Result of this study showed that there is an association between asthma symptoms and obesity in children. Therefore, any attempts for weight control in asthmatic children might be beneficial.
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Outpatient clinic
Circumference
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We explore the association with self-reported asthma and pulmonary function based on spirometry measurements using different measures to determine obesity because body mass index (BMI) is limited in not differentiating fat and muscle mass.A multi-year cross-sectional study using Korean National Health and Nutrition Examination Survey data was conducted between July 2008 and May 2011. A total of 9409 subjects were included in the final analysis.Obesity was associated with self-reported asthma and pulmonary function limitations mainly in adult women aged between 40 and 65 years and elderly men aged 65 or older. The association was stronger when the measurement of obesity was based on body fat percentage or waist-to-height ratio (WHtR), compared to BMI. There was a higher self-reported asthma risk among obese women according to the WHtR [odds ratio (OR) = 1.817, 95% CI: (1.208, 2.735)]. There was an increased risk of pulmonary function limitation with abdominal obesity [OR 1.418, 95% CI (1.020, 1.972)], weight-to-height ratio [OR 1.467, 95% CI (1.058, 2.034)], and obesity with regard to body fat percentage [OR 1.753, 95% CI (1.251, 2.457)] in adult women. In elderly men, obesity based on body fat percentage was associated with an increased risk of pulmonary function limitation [OR 1.93, 95% CI (1.098, 3.388)].Measures other than BMI should be examined when investigating the effect of obesity on self-reported asthma and pulmonary function limitation.
Waist-to-height ratio
Abdominal obesity
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Background: The prevalence of both obesity and asthma has risen in recent years. We sought to investigate whether obesity may be related to asthma.
Materials and methods: In this analytical study, 177 patients with asthma were enrolled. Obesity was defined as a body mass index (BMI) greater than 30. Asthma severity was defined by using the National Heart Lung and Blood Institute 1997 guidelines.
Results: Of the 177 patients, there were 80 males and 97 females. 38.4 percent of the sample was obese. There is no significant relationship between BMI and asthma severity (P=0.76) but as established by Pearsons correlation coefficient a positive and significant correlation is present between BMI and FEV1/FVC values (r=0.32 P=0.0001). Females with asthma were significantly more overweight than males (p = 0.001).
Conclusions: In our study, there was a significant correlation between body mass index and sex of patients with asthma. Women had the highest percentages of asthma compared to men, and had a higher body mass index than men.
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Objective: We hypothesized that, compared with body mass index (BMI) alone, central obesity would provide added information regarding types of asthma (allergic, nonallergic) and asthma severity. Materials and Methods: A total of 150 children aged between 7-17 years with 50 allergic asthma, 50 nonallergic asthma and 50 controls were included in the study. Height, weight, waist and hip circumferences of the groups were measured. Waist-to-hip ratio and BMI were calculated. Pulmonary function test results were recorded. The relation between anthropometric measurements, asthma, atopy, obesity and each other was analyzed. Results: Obesity according to BMI was higher in the group with allergic asthma than nonallergic asthma and the control group (p: 0.014). A positive correlation was found between asthma and BMI percentile, BMI z score and waist-to-hip ratio (p: 0.002; 0.003; 0.040, respectively). Children with obesity according to waist circumference were more frequent in the groups with allergic and nonallergic asthma compared to the control group (p: 0.048). There was a significant relationship between asthma severity and central obesity (p: 0.048). FEV1 / FVC and FEF25-75 were lower in the asthmatic groups compared to the control group (p: 0.028; 0.012, respectively). Conclusion: This study showed that central obesity was associated with asthma and asthma severity, but not with atopy. More investigation is needed to clarify how central obesity in children affects the control of asthma and the response to asthma medication. Keywords: Childhood asthma, central obesity, waist-to-hip ratio, body mass index
Atopy
Waist–hip ratio
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Black female
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Abstract Leptin, as a major adipokine, positively correlates with the body’s fat, while atopy is an important feature in the development of childhood asthma. We aimed to evaluate the relationship between leptin, parameters of obesity, and atopy in children with asthma. The study included 112 children (73 boys, 39 girls, mean age 11.1±2.4). 41 were overweight, 38 had asthma and a normal body mass index (BMI), and 33 were overweight asthmatics. Serum leptin levels, BMI, waist circumference (WC), and waist to hips ratio (WHR) were measured. Skin prick test (SPT)/CAP, total serum IgE, fractional exhaled nitric oxide (FeNO), and pulmonary function tests were performed. In asthmatic children, serum leptin median level was 9.2±16.2 ng/ml, in overweight children was 30.6±21.6 ng/ml, and in overweight asthmatics was 31.1±20.3 ng/ml with a significant difference between the groups (p=0.0374), yet with a significantly lower median level in the group of children with asthma compared to the overweight children: with asthma (p=0.00001) and without asthma (p=0.00001). In the three groups of patients, BMI and WC displayed a significant positive correlation with leptin (for BMI r=0.652 vs. r=0.530 vs. r=0.563, respectively and for WC r=0.508 vs. r=0.426 vs. r=0.527, respectively). No significant correlations of leptin within atopy parameters (Eo, IgE, SPT/CAP, FeNO) in all three analyzed groups (p>0.05) was detected. Conclusion : Atopy was not confirmed as an underlying mechanism of the association between asthma and being overweight. Leptin had a significant linear correlation as a parameter of central obesity with BMI and WC in all three groups, but not with WHR.
Atopy
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Objective. To evaluate the cross-sectional relationship between asthma and pre-gravid body mass index (BMI), and to assess the risk of adult weight change among women with history of asthma diagnosed in childhood or adulthood, respectively. Study design. Study participants were 3737 pregnant women enrolled in a cohort study. Information on history of asthma, pre-gravid BMI, adult weight change (difference between BMI at age 18 and pre-gravid BMI), and other sociodemographic characteristics was collected using interviewer-administered questionnaires. Pre-gravid BMI was categorized into lean (BMI < 18.5 kg/m2), overweight (BMI = 25–24.9 kg/m2), and obese (BMI ≥ 30 kg/m2). Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Results. Approximately 13.1% of study participants reported history of asthma. Compared with the reference group (BMI = 18.5–24.9 kg/m2), the odds of asthma was higher among overweight (OR = 1.51; 95% CI = 1.18–1.93) and obese (OR = 1.47; 95% CI = 1.06–2.03) women while it was lower among lean women (OR = 0.42; 95% CI = 0.21–0.84) (trend p-value <.001). Women who gained ≥20 kg compared with those who maintained their weight (±2.5 kg) had a 2.7-fold increased odds of asthma (95% CI = 1.02–7.00). Conclusions. Overweight and obese women were more likely to have a history of asthma. Adult weight gain was positively associated with asthma diagnosis. Longitudinal studies designed to prospectively assess patterns of adult weight change in relation to asthma are warranted.
Weight change
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To investigate association between nutritional status, adiposity and asthma severity and control in children.We conducted a case control study at two teaching hospitals in Brazil. Cases were children (3-12 years) with persistent asthma and age-matched controls were those with intermittent asthma. Nutritional status was assessed by body mass index (BMI). Adiposity was assessed by sum of skinfolds and waist circumference (WC). Crude and adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using conditional logistic regression or multinomial logistic regression as appropriate.Two hundred sixty-eight cases and 126 controls were included. Obesity (>2 BMI z-score for age) was significantly associated with persistent asthma (adjusted OR 2.62; 95% CI 1.39-4.95). There was a significant linear relationship between BMI z-scores (≤1, >1 to ≤2, >2) and risk of having persistent asthma (P = 0.003 for linear trend). Children with WC >90th percentile had a higher risk of persistent asthma when compared with those with WC ≤90th percentile (adjusted OR 3.38; 95% CI 1.26-9.06). No significant difference was found in terms of nutritional status and adiposity between children whose asthma was controlled by inhaled corticosteroids and those requiring inhaled corticosteroids plus other medications for asthma control.Obesity measured by BMI and increased abdominal adiposity are significantly associated with risk of persistent asthma but not type of controller medications.
Abdominal obesity
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To examine the association of body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR) with the prevalence of asthma by atopic status and sex using nationally representative data in the US.The National Health and Nutrition Examination Survey 2005-2006 data were analyzed using areas under the receiver operating characteristic (ROC) curves (AUCs) and multivariate logistic regression models.Women had higher AUCs (0.59-0.64) than men (0.50-0.58) across anthropometric indices and asthma outcomes. After controlling for sociodemographic characteristics and smoking status, only WHtR was positively associated with atopic asthma in both sexes (odds ratio per 1 SD [95% confidence interval]: men, 1.018 [1.004, 1.032], p = .01; women, 1.018 [1.006, 1.030], p = .003), and the associations persisted after further adjustment of BMI. Only in women was nonatopic asthma significantly associated with every 1 SD increase of BMI (odds ratio [95% confidence interval]: 1.018 [1.006, 1.030], p = .003), WC (1.018 [1.006, 1.030], p = .004), and WHtR (1.016 [1.004, 1.028], p = .008).Using US national data, this study adds to the emerging evidence suggesting two possible distinct phenotypes: (1) obese men and women with atopic asthma and (2) obese women with nonatopic asthma. The mechanistic and therapeutic implications of these findings warrant further investigation.
Waist-to-height ratio
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