The curative effect of Triamcinolone acetonide and ratinoic acid to keloid
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Abstract:
Objective To observe the curative effect of Triamcinolone acetonide combined with ratinoic acid treating keloid. Methods 55 cases of keloid patient were devided into two group randomly, treatment group and control group.The treatment group composed by 29 keloid patients was treated with Triamcinolone acetonide and ratinoic acid; The control group by 25 keloid patients was treated with Triamcinolone acetonide only. Results The curative rate and total efficacy rate of treatment group was 58.62% and 93.11% respectively, while which of control group was 26.92% and 73.07%. The curative rate and total efficacy rate between two groups were significantly different. Conclusion The method of local blockage with Triamcinolone acetonide conbined with ratinoic acid was effective in treating keloid.Keywords:
Keloid
Acetonide
Cure rate
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This study was undertaken to investigate the possible pituitary-adrenal suppressive effects of triamcinolone acetonide under occlusive dressings in six psoriatic patients. Forty-five grams of a cream containing 0.1% triamcinolone acetonide was applied daily to the psoriatic lesions of four patients and covered with an occlusive dressing. Two patients received daily applications of 45 gm of 0.01% triamcinolone acetonide cream and occlusive dressings. The four patients who received the 0.1% triamcinolone acetonide applications showed a marked decrease in the 24-hour urinary 17-hydroxycorticosteroids and no significant response to intravenous metyrapone testing. The two patients who were treated with 0.01% triamcinolone acetonide also showed a significant decrease in 24-hour urinary 17-hydroxycorticosteroids, but a partial response to metyrapone testing. Percutaneous absorption of as little as 1 to 2 mg of triamcinolone acetonide may affect pituitary-adrenal function.
Metyrapone
Acetonide
Adrenal function
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Citations (16)
Objective
To explore and analyze the clinical value of hyaluronidase and triamcinolone acetonide in the treatment of keloid.
Methods
100 patients with keloid admitted to our hospital from January, 2016 to December, 2018 were selected and divided into an observation group (51 cases) and a control group (49 cases) by random number table. The observation group were treated with hyaluronidase and triamcinolone acetonide, while the control group with triamcinolone acetonide. The clinical treatment effects, clinical indicators, and adverse reactions of the two groups were analyzed and compared.
Results
The cured rate, total effective rate, and the inefficiency rate of the observation group were 58.82% (30/51), 98.04% (50/51), and 1.96% (1/51), which were better than those in the control group, with statistical differences (all P<0.05). The height of scar tissue eminence, the pain score, and the pruritus score were (2.13±0.32) mm, (2.08±0.31) and (1.29±0.23) in the observation group, which were lower than those in the control group (all P<0.05). The total incidence of adverse reactions, such as premenstrual menstruation, pigmentation, and telangiectasia, was 7.84% (4/51) in the observation group, which was lower than that in the control group (P<0.05).
Conclusion
Hyaluronidase and triamcinolone acetonide keloid patients is effective and safe.
Key words:
Keloid; Hyaluronidase; Triamcinolone acetonide
Keloid
Acetonide
Hyaluronidase
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Objective To investigate the clinical effect and safety of pingyangmycin combined with triamcinolone acetonide in the treatment of keloids.Methods One hundred and thirty-fve outpatients with keloids were divided into group A,B and C randomly.Forty-fve patients in group A were treated with local pingyangmycin and triamcinolone acetonide injection once a month for 1 to 2 times.Forty-fve patients in group B were treated with triamcinolone acetonide once a month for 1 to 2 times.Forty-five patients in group C were treated with pingyangmycin once a month for 1 to 2 times.Results The results of group A after treatment showed that the cured rate and total effect rate were 62.22% and88.89%,respectively.The results of group B after treatment showed that the cured rate and total effect rates were 48.89% and 68.89% respectively.The results of group C after treatment showed that the cured rate and total effect rate were 31.11% and 64.44% respectively.The effect rate in group A was significant higher than that of group B and C(χ2= 5.4040,P=0.0201;χ2= 7.5155,P=0.0061).The effect rate in group B was no statistical signifcant with group C(χ2=0.2000,P=0.6547).Conclusion This investigation indicates that pingyangmycin combined with triamcinolone acetonide are an effcacy and safety therapy in the treatment of keloids.
Pingyangmycin
Acetonide
Cure rate
Group B
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Objective: To analyze the effectiveness of phosphorus 32 (32P) application compared to 10 mg/cc triamcinolone acetonide (TA) intralesional injection in keloid. Methods: A single blind (evaluator blind) randomized clinical trial on 52 keloids was conducted during the period of May – August 2014 in Tumor and Skin Surgery Clinic, Department of Dermatovenereology and Department of Nuclear Medicine and Molecular Imaging, Dr. Hasan Sadikin General Hospital Bandung. Results: Lesions were divided into two groups with each group consisted of 26 lesions. Group A was treated with 32P application whereas group B was treated with 10 mg/cc TA intralesional injection. Flattening of the lesion of more than 50% was higher in the group treated with 32P application (76.9%) compared to the group that was treated with 10 mg/cc TA intralesional injection (57.7%) on the 8th week, but the difference was not statistically significant (p>0.05). Conclusions: Based on the statistical analysis, the application of 32P was as effective as the intralesional injection of 10 mg/cc TA for keloid lesions. Keywords: Flattening, keloid, phosphorus 32, triamcinolone acetonide DOI: 10.15850/ijihs.v4n1.683
Keloid
Acetonide
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Citations (2)
Background: Management of keloid is difficult as well as challenging. Intralesional triamcinolone acetonide (TAC) injections have remained a gold standard in non-surgical management of keloid. TAC is generally used in the concentration of 40mg/ml, which causes adverse effects such as local dermal atrophy and hypopigmentation. Aim was to study efficacy and adverse effects of TAC in treatment of keloid, in a lesser concentration of 20mg/ml.Methods: An open label study was conducted from November 2015 to May 2017 on 25 subjects of either gender, in the age group 11-55 years, at a medical college hospital. Intralesional injection TAC 20 was administered in the keloid at an interval of 3 weeks, for a total of 6 sessions, over a period of 18 weeks. Vancouver scar scale (VSS) was used to assess the improvement and SPSS 21 for statistical analysis.Results: Mean age of keloid subjects was 30.72 years and median duration of keloid was 8 months. The mean VSS score before treatment was 8.36 which reduced to 3.20 after treatment. Mean percentage change in VSS score was 62.79%, which was very highly significant (p <0.001). Physician’s assessment was ‘Very Good’ in 52.0% and ‘Excellent’ in 5 (20%). Adverse effect of atrophy was seen in 3 (12%), hypopigmentation in 11 (44%) and telangiectasia in 4 (16%).Conclusions: Intralesional injection triamcinolone acetonide 20mg/ml gives very good to excellent improvement in the majority of patients of keloid. Local adverse effects seen were hypopigmentation, atrophy and telengiectasia.
Keloid
Hypopigmentation
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Citations (14)
Management of keloid is difficult, so there is always a need for adequate and effective therapy. In this study, we explored and compared the efficacy and synergistic effect of combined intralesional radiofrequency (RF) and intralesional triamcinolone acetonide (TAC) with intralesional triamcinolone acetonide alone in the treatment of keloids. Sixty patients with keloid were divided in two groups of 30 patients each. In both groups total six sittings every 3 weeks and post treatment follow-up every 6 weeks was done. In group A, intralesional TAC was given. In group B, intralesional radiofrequency followed by triamcinolone was injected. In this study, there were 29 males and 31 females. In groups A and B, 73.4% and 80% of the patients, respectively, achieved grade 4 improvement at the end of 33 weeks, but there was greater mean POSAS score decline in group B in comparison with group A at each visit compared to baseline. Six patients in group A while three in group B showed recurrence. Side effects were equal in number in both groups Thus both the studied modalities of treatment produced equal efficacy and safety but with less recurrence in group B.
Keloid
Group B
Acetonide
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Background: The current study was performed to compare the effects of ablative fractional CO2 laser plus triamcinolone acetonide cream versus intralesional injection of triamcinolone acetonide in the treatment of hypertrophic and keloid scars. Methods: This quasi-experimental study was performed among 33 patients visiting dermatology clinics of two referral teaching hospitals during 2013 - 2014.A lesion of these patients was divided in to two equal parts, one half was injected with triamcinolone acetonide at a dose of 10 - 20 mg/mL, and in the combination treatment, we administered ablative fractional CO2 laser treatment (level: 15, point of shot: 5, PW: 5, pitch: 0.5; Unixel, Korea) with topical triamcinolone acetonide in the other half. The settings of the laser device for each session were set according to the thickness of the scar. Immediately after laser treatment (in the first two seconds) and up to one week later, the triamcinolone acetonide 0.1% cream was applied twice a day. Each patient underwent 3 - 5 treatment sessions of laser treatment at 4-week intervals for one lesion. One hour before each session, the local anesthetic, lidocaine-p gel, was administered around the lesion. Results: The general appearance of the wound was better in the intralesional triamcinolone group (1.53 vs. 2.15, P < 0.0001). Dyschromia showed more improvement in the combination treatment (1.13 vs. 1.47, P < 0.0001), while hypertrophy improved more as a result of intralesional triamcinolone acetonide injection (2.19 vs. 1.52, P < 0.0001). Additionally, combination treatment was more effective on texture (1.61 vs. 2.11, P < 0.0001). The improvement of symptoms scores was 2.73 out of a total of three. Conclusions: It can be concluded that topical corticosteroids plus fractional laser therapy is more effective than intralesional injection of corticosteroids for the amelioration of dyschromia and texture of hypertrophic and keloid scars. However, general appearance and hypertrophy showed a better response to intralesional injection of triamcinolone. Accordingly, in non-homogenous lesions with dyschromia, the use of local corticosteroids plus fractional laser is recommended.
Keloid
Ablative case
Acetonide
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To evaluate the clinical effects of the mixture of 5-fluorouracil (5-FU) and triamcinolone acetonide on capillary hemangioma of eyelid.One hundred and one patients with capillary hemangioma of eyelid were divided into Group A and Group B: Group A was injected with triamcinolone acetonide, and Group B was injected the mixture of 5-FU and triamcinolone acetonide.The cure rate was 68.3%, the total effective rate was 76.0%, and the average course of treatment was (8.1+/-3.4) months for Group A; the cure rate was 90.0%, the total effective rate was 96.6%, and the average course of treatment was (5.1+/-2.3) months for Group B. The therapeutic effect in Group B was better than that in Group A (P<0.05). The treatment period in Group B was shorter than that in Group A (P<0.05).5-FU combining with triamcinolone acetonide has not only a better therapeutic effect, but also a shorter period of treatment.
Acetonide
Group B
Therapeutic effect
Cure rate
Capillary hemangioma
Group A
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Objective:To observe the effect of injective triamcinolone acetonide for the treatment of keloid.Methods:A total of 30 keloids in 28 cases were all treated with injective triamcinolone acetonide.Injection levels were taken into account seriously.The drug was only injected into scar entity.Results:19 keloids were cure,9 were markedly effective,and two invalid.Conclusion:Keloid can be effectively treated with triamcinolone acetonide.
Keloid
Acetonide
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Objective To evaluate the effects of intralesinal triamcinolone acetonide mixed with 5-fluorourcil on hypertrophic scars. Methods 58 cases patients with hypertrophic scar and keloid were randomly divided into the treatment group and the control group.The hypertrophic scars and keloid were injected intralesionally with triamcinolone acetonide mixed with 5-fluorouracil(treatment group), triamcinolone acetonide(control group). The curative rate and effective rate of those two groups were compared. Results All cases were followed up from 12~18 months. The curative rate was 75.86 %(treatment group )and 48.28 %(control group ); the effective rate was 93.1 %(treatment group )and 72.41 %(control group ). The different of curative rate and effective rate between treatment group and control group is significant. Conclusion The therapeutic effect on hypertrophic scars and keloid after treatment with intralesinal triamcinolone acetonide mixed with 5-fluorourcil appears to be both effective and safe.
Keloid
Hypertrophic scars
Hypertrophic scars
Acetonide
Therapeutic effect
Cure rate
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