The Clinical Study of Scopolamine Combined with Prostaglandin E_1 Treatment of Pulmonary heart disease with Respiratory Failure
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Objective To explore the carative effects of scopolamine combined with prostaglandin E_1 in treatment of pulmonary heart disease with respiratory failure. Methods 72 cases were randomly divided into control group (37 casess) with routine therapy and experimental group (35 cases) with scopolamine combined with prostaglandin E_1 based on routine treatment. The to evaluate the results. Results The rate of effect was 85.7% in experimental group and 45.9% in the control group,there was a significant difference in statitics (P0.01). The experimental group’s PaO_2 and SaO_2 in post-treatment one wkke were significantly higher than in the control group (P0.01). Conclusions Scopolamine combined with prostagiandin E_1 was obviously effective in the treatment of pulmonary heart disease with respiratory failure.Keywords:
Scopolamine
Pulmonary heart disease
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Objective To study the non-selective endothelin receptor antagonist bosentan for treatment of children with congenital heart disease(congenital heart disease,CHD) associated pulmonary arterial hypertension( pulmonaryarterial hypertension,PAH) the clinical efficacy and safety. Methods From 2011 April to 2012 March in Laiwu People's Hospital of Shandong Province from 32 cases of congenital heart disease in children,were randomly divided into treatment group and control group( n = 16). Control group was given routine cardiac diuretic therapy,treatment group were treated with bosentan on the basis of the control group,pulmonary arterial pressure,pulmonary vascular resistance,6 min walk test,heart rate( HR),the changes of cardiac function and liver function index difference were observed 6 months after treatment. Results Before treatment,pulmonary artery systolic pressure,diastolic pulmonary artery pressure,pulmonary arterial resistance and HR between control group and treatment group,were not significant; after treatment,the pulmonary arterial systolic pressure,diastolic blood pressure in treatment group and control group significantly decreased(P 0.05),those indexes in treatment group were significantly lower than the control group,the difference was statistically significant(P 0.05). Before treatment,two groups of children with LVEDD,EF,RVD,PGVT were not significantly different. After treatment,the treatment group was significantly longer than that of the control group in 6 min walking distance( P 0. 05). Before and after treatment in two groups: BUN,CREA,AST,ALT were not significantly different. Conclusion Non-selective endothelin receptor antagonist for the treatment of CHD associated PAH could improve the pulmonary arterial pressure and improve pulmonary exercise tolerance with good security.
Endothelin receptor antagonist
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Objective To explore the therapeutic effect of phentolamine plus dopamine in children with heart failure following pneumonia.Methods Totally 64 cases with heart failure following pneumonia were divided into treatment group and control group at random.The control group was treated by conventional program.The treatment group was administrated phentolamine plus dopamine through intravenous drip on the conventional program.Results The curative rates of heart failure were 93.75% and 84.38% in treatment and control groups,respectively(P0.05).The mean time of hear failure to be corrected were remarkably shorter in treatment group than that of control group(P0.01).The times of administration of cardiac glycoside were less in treatment group than that of control group(P0.05).Conclusion The duration of heart failure was shortened and the times of administration of cardiac glycoside were decreased by phentolamine plus dopamine in the children with heart failure following pneumonia.
Phentolamine
Cardiac glycoside
Therapeutic effect
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Objective To observe the effect of trimetazidine dihydrochloride on heart function in patients with chronic pulmonary heart disease.Methods Sixty four patients with chronic pulmonary heart disease were randomly divided into routine treatment group(n=30) and trimetazidine dihydrochloride treatment group(n=34).Patients in treatment group were given both the routine treatment and trimetazidine 20 mg,3 times daily for 8 weeks;while patients in routine treatment group were given only the routine treatment.These patients were followed up for 8 weeks,clinical and laboratory data were recorded before and after follow-up which included symptoms,signs,left ventricular ejection fraction(LVEF),cardiac index(CI), cardiac output(CO),arterial oxygen pressure(PaO_2),arterial carbon dioxide pressure(PaCO_2),mean pulmonary artery pressure(MPAP).Results Compared with the routine treatment group,trimetazidine treatment group significantly released the clinical symptoms of heart failure in patients with chronic pulmonary heart disease,and the total effective rate in treatment group) were significantly higher than those in routine treatment group((91.18%vs 80.00%,P0.05).The LVEF(P 0.05),CI(P0.05),CO(P0.05),and hypoxia(P0.05) in treatment group were significantly improved than those before treatment and control group.Conclusion Trimetazidine dihydrochloride can improve heart function in patients with chronic pulmonary heart disease based on the conventional treatments.
Trimetazidine
Pulmonary heart disease
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Objective To explore the clinical effects of ligustrazine combined with phentolamine in the treatment of chronic pulmonary heart failure. Methods A total of 78 cases with chronic pulmonary heart failure were randomly divided into control group( n = 38) and experiment group( n = 40). The include 78 cases were all treated with general treatment such as antibiotics, eliminating phlegm and so on. And patients in the experiment group were given phentolamine 10 mg with 5%glucose 250 mL through intravenous drop infusion bid for 10 days plus ligustrazine 240 mg with 5% glucose 250 mL by intravenous drop infusion qd for 10 days on the basic treatment of control group. The data of clinical symptom improvement,CI,PASP and blood gas index were compared between the two group before and after treatment. Results After treatment, the heart function in the experiment group was significantly improved than control group( P 0. 05). The pulmonary function such as PASP,Pa CO2,Pa O2 and Sa O2 in the two groups were significantly improved in both groups( P 0. 05). Conclusion Ligustrazine combined with phentolamine can significantly improve the clinical efficacy of patients with chronic pulmonary heart failure, with significantly improved heart function.
Phentolamine
Clinical efficacy
Therapeutic effect
Clinical treatment
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Objective To observed the clinical effect of phentolamine in the treatment of chronic pulmonary heart disease with heart failure. Methods 70patients were randomly divided into control group ( n = 35) and therapy group( n = 35). Two groups were treated with medical treatment,such as control infection、oxygen therapy、cardiotonic、diuresis. On the basis of the above therapy,the treatment group add phentolamine 10 mg with normal saline 50 ml in micro-pump intravenous injection ( 5 ml / h) ,quotidie,10 days for a course of treatment. Results Compare with the control group,the therapeutic effect 、clinical symptoms、blood gas analysis、heart function in therapy group were significant difference( P 0. 05). Conclusion Phentolamine in the treatment of chronic pulmonary heart disease with heart failure is effective and safe. It deserves to be popularized.
Phentolamine
Therapeutic effect
Pulmonary heart disease
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OBJECTIVE:To observe clinical efficacy of nitroglycerin combined with dopamine in the treatment of heart failure of chronic pulmonary heart disease. METHODS: 68 patients with heart failure of chronic pulmonary heart disease were randomly divided into experimental group and control group from Feb. 2008 to Dec. 2010 in our hospital with 34 cases in each group. Control group was given conventional treatment, which included anti-infection, oxygen therapy, diuretic phlegm, relieving cough and asthma, and patients with higher heart rate (100·min-1) received cedilanid 0.2 mg, intravenous injection addtionally. Experimental group received nitroglycerin 6～10 mg combined with dopamine 20 mg on the basis of control group,qd,treat 7～10 d. The clinical efficacy and the hospital stay time were compared between 2 groups. RESULTS: The total effective rate of experimental group was 97.06%, which was higher than 67.65% of control group, there was statistical significance (P0.05); the hospital stay time in experimental group was shorter than in control group (P0.05). There were no serious ADR in both group. CONCLUSION: Nitroglycerin combined with dopamine is effective and safe in the treatment of heart failure of chronic pulmonary heart disease.
Pulmonary heart disease
Nitroglycerin (drug)
Phlegm
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AIM To explore the clinical effects of milrinone on elderly patients with heart failure induced by chronic pulmonary heart disease. METHODS A total of 80 patients with heart failure induced by chronic pulmonary heart disease were randomly divided into treatment group and control group, 40 for each group.Comprehensive therapies were given to both groups after hospitalization, including continuous oxygen inhalation in low flow, infection controlling, diuresis, electrolyte and acid base disturbance rectification, cough relieving to remove phlegm and spasm remising to relieve asthma. The treatment group was added with intravenous injection of milrinone 50 μg·kg-1, while the control group was intravenously injected with dobutamine 20-40 mg, qd for 7 d, respectively. Clinical effects, heart rate(HR), arterial blood partial pressure of oxygen( PaO2) and partial pressure of carbon dioxide( PaCO2), left ventricular ejection fraction( LVEF), stroke volume(SV), cardiac index(CI), cardiac output(CO) per minute and the ratio of maximum flow velocity in diastolic early and late vacation of mitral valve flow(E/A) of both groups were observed and compared. After the treatment, serum sulfuretted hydrogen(H2S) level was detected with deproteinization method while serum amino-terminal B-type brain natriuretic peptide( BNP) and D-dimer levels were determined by immunoflurorescence method. RESULTS Total effective rate of the treatment group was 88% and the control group was 68%, but there was no significant difference between the groups(P 0.05). HR, PaCO2, BNP and D-dimer levels decreased while H2 S and PaO2 levels increased obviously in both groups(P 0.05), and the treatment group was lower in HR, H2 S and PaCO2 levels but higher in PaO2, BNP and D-dimer levels than the control group(P 0.01). Additionally, SV, CO, CI, LVEF and E/A increased evidently after the treatment(P 0.05), and the treatment group were higher than the control group(P 0.05). CONCLUSION Milrinone has favorable effects in treating patients with heart failure induced by chronic pulmonary heart disease.
Milrinone
Cardiac index
Dobutamine
Pulmonary wedge pressure
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Objective To observe clinical efficacy of phentolamine,dopamine,and dexamethasone in treatment of pulmonary heart failure.Methods Fifty-eight hospitalized heart failure patients with pulmonary heart disease were randomly divided into treatment group(32 patients) and control group(26 patients).All patients were given oxygen,infection control,antispasmodic,diuretic,treatment as cardiac timely conventional therapy.Based on the normal treatment,treatment group was given phentolamine,dopamine and dexamethasone treatment.Results By comparing the two groups,treatment group were better than the control group in the correct time and shortening the course of disease(P0.01).The total effective rate in treatment group was 93.7%,while the control group was 76.9%,the difference was statistically significant(P0.01).Conclusion The combination of phentolamine,dopamine and dexamethasone treatment has remarkable effect in treatment of pulmonary heart failure.
Phentolamine
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Objective To observe the clinical therapy effect of phentolamine and dobutamine combined administration for chronic cardiopulmonary disease complicated with heart failure and respiratory failure.Methods 240 patients of chronic cardiopulmonary disease complicated with heart and respiratory failure were enrolled and randomly divided into the observation group(n = 120) and the control group(n = 120).The control group received controlling of respiratory tract infections,continuous low flow oxygen inhalation,keeping respiratory tract from impeding and the routine treatment for improving respiratory function and correcting hypoxia.The observation group was administered with phentolamine and dobutamine in intravenous way based on the routine treatments.Results The effective rate of observation group was statistically higher than that of the control group(95.0% vs 74.2%,P 0.01).After treatment,the forced expiratory volume in one second(FEV1) and ejection fraction(EF) of the two groups were significantly increased compared with the baseline(P 0.05).The observation group demonstrated better therapeutic effects of FEV1(P 0.05) and EF(P 0.01) than those in the control group.Conclusion Combined administration of phentolamine and dobutamine showed notable curative effect in patients with chronic cardiopulmonary disease complicated with heart and respiratory failure;it is worth of clinical application.
Dobutamine
Phentolamine
Chronic respiratory failure
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Objective To observe the effect of prostaglandin E1 in treatment of pulmonary hypertension. Methods Patients with pulmonary hypertension were divded into two groups randomly, one group were given routine treatment and nifedipine orally, another group plus prostaglandin E1 intravenous drip, to compare the changes of pulmonary hypertension before and after treatment. Results The two groups counld decrease pulmonary hypertension effectly, but prostaglandin E1 counld remarkablely decrease pulmonary hypertension with significantly comparative difference (P 0.05). Conclusion Prostaglandin E1 intravenous drip on the basis of routine treatment and oral nifedipine counld remarkablely decrease pulmonary hypertension, and improve the clinic symptoms of patients.
Prostaglandin E1
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