Study of relationship between pulse pressure and severity of coronary heart disease
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Objective To evaluate the relation of the pulse pressure (PP) to the severity of coronary artery disease Methods Three hundred seventy four patients with coronary artery disease were diagnosed by coronary angiography, 306 male patients, 68 female patients, mean age 31～81 (58 1±10 1) years old Brachial systolic and diastolic blood pressure were measured The severity of coronary heart disease was shown as the number of diseased arteries Results Patients with essential hypertension (EH)had higher incidence of 2 coronary artery disease (37 5% vs 8 6%) and 3 coronary artery disease (27 2% vs 14 8%) than those without EH ( P 0 001) Compared to patients with PP65mm Hg, patients with PP≥65mm Hg had higher incidence of 3 coronary artery disease (35 9% vs 19 4%, P 0 05) In a multivariate analysis, age and aortic dimension were the best predictor for the severity of coronary lesions Conclusion Pulse pressure was the simpliest parameter reflecting large artery elasticity and closely related to severity of coronary artery disease This parameter could be a marker of cardiovascular risk, instructing early interventionKeywords:
Pulse pressure
Brachial artery
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Objective:To investigate the relationship between pulse pressure(PP) and coronary artery lesions in the senile with coronary artery disease(CHD) and hypertension.Method:47 patients with CHD and hypertension who had coronary argiography,aged over 60 year(63.5±2.6 years),weighted 50～70(57.2±3.4 kg) with hormal blood sugar,lipid,apolipoprotein and fibrinogen were selected.They were devided into two groups:group A with PP50mmHg(n=31) and group B with PP≤50mmHg(n=16).The structure of coronary artry in two groups was analyzed.Result:There was statistical difference in the degree of coronary artery stenosis between two groups.Conclusions:PP may be an independent and important factor for the degree of coronary artery stenosis.PP may be helpful to the risk gradation and antihypertension therapy.
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Objective To evaluate the relationship between pulse pressure(PP) and the severity of coronary artery stenosis.Methods Three hundred and forty patients who were suspected or diagnosed as coronary artery disease were enrolled.They were divided into normal control group(120 cases),single-vessel lesion group(78 cases),doublevessel lesion group(66 cases) and triple-vessel lesion group(76 cases) according to the number of diseased arteries.And the severity of coronary artery stenosis was evaluated by Gensini score.To compare the relationship of aortic pulse pressure and the severity of coronary artery stenosis among the four groups.Results The aortic pulse pressure was significantly higher in patients with coronary artery disease than that in the normal subjects.Multiple regression analysis indicated that aortic pulse pressure was closely related to the severity of coronary lesions.Conclusion Pulse pressure is an independent risk factor for the severity of coronary artery stenosis,and aotic pulse pressure is a better predictor.
Pulse pressure
Aortic pressure
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Objective:To study the changes of peripherial artery elasticity indexes in patients with coronary artery disease (CAD). Methods:After percutaneous transluminal coronary angiography,a total of 106 patients with CAD and 84 normal subjects were recruited. Large artery elasticity index (C1) and small artery elasticity index (C2) of these subjects were measured. The relationship between cardiovascular risk factors (age,hypertension and diabetes history,pulse pressure),the number of diseased coronary artery and artery elasticity was analysed. Results:(1) C1 and C2 in patients with CAD were lower significantly than controls. (2) C1 and C2 in patients combined with hypertension were lower significantly than that in normotensive patients.C2 in patients combined with diabetes were lower significantly than that in nondiabetic patients. (3) With the numbers of diseased coronary artery and pulse pressure increasing,C1 and C2 in patients decreased significantly. (4) The multiple regression analysis indicated that age,pulse pressure and the number of diseased coronary artery were risk factors which affected C1. And diabetes mellitus was risk factor,which affected C2 except for above factors. Conclusion:Artery elasticity indexes (C1 and C2) might partly be the important non-invasive indexes,which could be used to evaluate the artery function of patients with CAD.
Pulse pressure
Elasticity
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Objective To evaluate the relationship between vascular endothelial function of coronary heart disease and the severity of coronary artery disease(CHD).Methods 73 patients undergoing coronary angiography were divided into two groups:CHD group(n=39)and non-CHD group(n=34)according to the result of coronary angiography.13 healthy subjects without risk factor of CHD were chosen as normal control group.FMD and NTG-MD of endothelial-dependent and independent dilatation of brachial artery were measured by using of high frequency linear-array uhrasonography for assessment of the vascular endothelial function.and the relationship between the vascular endothelial function and the severity of coronary artery stenosis was analyzed.Results A significant difference was obtained in the FMD among the CHD group,non-CHD group and control group[(4.81±2.33)%vs.(9.29±3.88)%vs.(13.58±1.80)%,F=48.012,P＜0.01).Significant difference was shown in NTG.MD among the three groups[(13.72±3.27)%vs.(15.64±2.65)%vs.(16.54±2.98)%,F=6.015,P＜0.01]and significant difference was shown between CHD group and the other two group(P＜0.05).The FMD was negatively correlated with the basdine value of the brachial artery.tlle number of stenotic coronary ateries and the severity of coronary artery stenosis(r=-0.224,-0,316,-0.721,P=0.038,0.003 and ＜0.001).NTG-MD was also negatively correlated with the baseline value of the brachial artery,the number of stenotic coronary arteries and the severity of coronary artery stenosis(r=-0.483,-0.258,-0.372,P＜0.001,0.027,0.001).Stepwise regression analysis displayed a linear relationship between FMD and the severity of coronary artery stenosis,the baseline value of the brachial artery(r=-0.012,-0.022,P＜0.001).NTG-MD was linearly related to the baseline value ofthe brachial artery and the severity of coronary artery stenosis(r=-0.032,-0.0073,P＜0.001).Conclusion The degree of damage of endothelial function of coronary heart disease is linearly correlated with severity of coronary arteIT stenosis.
Key words:
Coronary heart disease; Uhrasonography; Flow mediated dilatation; Endothelial function
Brachial artery
Endothelial Dysfunction
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Objective: To evaluate clinical value of early vascular disease detection system in patients with hypertension and coronary heart disease.Methods:132 subjects were included in our study,48 normal subjects,42 hypertensive patients,42 coronary heart disease patients,the mean age was 55.54±9.59 years(33~85 years old).The change of artery structure and function were evaluated by ultrasound and arteriosclerosis examine system in all subjects.Results: Carotid plaque were more common in coronary heart disease and hypertension group than that of in normal group(35.7%,16.6%,12.5%,respectively,P0.05).Ep and βwere higher in patients with hypertension group and coronary heart disease group than that of in normal subjects,and AC was lower in patients with hypertension group and coronary heart disease group.Ep was significantly higher in patients with hypertension and coronary heart disease than that of normal subjects[(163.96±73.90) kPa vs(114.77±35.03) kPa,P0.01;(143.75±64.33) kPa vs(114.77±35.03) kPa,P0.05,respectively].βwas significantly higher in patients coronary heart disease than that of normal subjects(11.99±4.50 vs 9.32±2.88,P0.01).AC was significantly lower in patients with hypertension group than that of normal subjects[(0.64±0.21) mm~2/kPa vs(0.73±0.27) mm~2/kPa,P0.05].Carotid-femoral pulse wave velocity(C-FPWV)and brachial-ankle pulse wave velocity(BaPWV) were higher in patients with coronary artery disease[(11.72±2.54) m/s,(1601.45±267.20) cm/s,P0.05];ankle-brachial index(ABI) were lower in coronary artery disease group than that of in hypertension and normal groups((1.09)±0.14,1.14±0.06,1.15±0.07,respectively,P0.05).Conclusions: The early change of the artery function and structure can be estimated conveniently,quickly and non-invasively by ultrasound and other techniques.Early vascular disease detection system could be useful for vascular disease prevention and prognosis evaluation in patients with cardiovascular risk.
Arteriosclerosis
Hypertensive heart disease
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Objective:To investigate in patients with hypertension with different degree of coronary heart disease brachial artery diameter,coronary heart disease in patients with hypertension to explore the brachial artery endothelial function changes.Methods:The subjects in my line of patients with coronary angiography in 120 cases,all income groups have been clearly diagnosed cases of hypertension,and in accordance with the results of angiography were divided into two groups,high blood pressure with coronary heart disease group,a total of 78 cases,according to coronary artery lesions involving the patients in this group will be divided into 3 groups:(1) single lesions;(2) double-vessel group;(3) 3 or more lesions support group;simple hypertension have high blood pressure but normal coronary angiography results,or narrow50%,a total of 42 cases.Through the brachial artery ultrasonography Neijing basis,after pressure 30, 60 s values of the diameter.Results:The pressure after the 30,60 s value of the diameter of the risk stratification of coronary heart disease-related.30 s after compression of coronary heart disease risk stratification of single,double and multi-vessel disease were associated(P0.05).Group comparison of coronary heart disease group:three states of brachial artery blood flow velocity of the average smoking levels,triglyceride, low density lipoprotein was a positive correlation,brachial artery under the three states with an average velocity of high-density negative correlation lipoprotein.Conclusion:Hypertensive patients with coronary heart disease increased with the degree of coronary artery disease,arterial endothelial dysfunction has also increased the risk;the extent of coronary heart disease more emphasis on its smoking levels,triglyceride, low-density lipoprotein values of the greater lower high-density lipoprotein;vascular endothelial function method of ultrasonic testing in the high blood pressure,coronary heart disease and coronary heart disease in patients with hypertension with the severity of coronary vascular lesions have been to help the judge.
Brachial artery
Endothelial Dysfunction
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Objective: To investigate the relationship between pulse pressure(PP) and severity of coronary artery stenosis.Methods: Three hundred and thirty-eight patients were enrolled,all the patients underwent coronary angiography and their systolic blood pressure(SBP) diastolic blood pressure(DBP) and PP were measured then the relationship between PP and severity of coronary artery stenosis was determined.According to 24 hPP and the results of coronary angiography,all the patients were repectively divided into two groups:(1) the group of 24 hPP60 mmHg and the group of 24 hPP≥60 mmHg.(2) coronary stenosis group and normal coronary group,coronary stenosis score and the stenosis rate were compared between the two groups.Results: The degree of coronary artery stenosis in the group PP≥60 mmHg was higher than that of the normal group(P0.05).Conclusion: PP levels were significantly higher in patients(P0.001) with coronary artery disease than that in the normal subjects.
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Objective To evaluate the relationship between pulse pressure(PP)and the severity of coronary artery stenosis.Methods 405 patients were enrolled.Of them,271 were men and 134 women,whose ages were 33-85(63.02±11.18)years.All patients underwent coronary angiography.The severity of coronary artery stenosis was evaluated by the number of diseased arteries and Gensini score.Aortic blood pressure and radial artery blood pressure were measured during coronary angiography.Results The aortic SBP and PP,and radial SBP and PP were significantly higher in patients with coronary artery disease than in the normal subjects.Multiple regression analysis indicated that aortic PP,radial PP,and age were closely related to the severity of coronary lesions.Conclusion PP is an independent risk factor for the severity of coronary artery stenosis,and aotic PP is a better predictor.
Pulse pressure
Aortic pressure
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The aim of this study was to assess the relationship between 24 h blood pressure (BP) profile, extent of significant coronary artery stenosis, confirmed by coronary angiography, and cardiovascular events in patients with coronary artery disease. Coronary angiographies were performed for all included subjects and significant coronary artery stenosis was considered as ≥ 50% stenosis by atherosclerotic plaque. Twenty-four-hour ambulatory BP monitoring was performed. Major advanced cardiovascular events (MACE) included revascularization, cardiovascular mortality, total mortality, acute coronary syndromes and stroke. BP analysis revealed higher night-time systolic blood pressure (SBP) values in patients with three or more significant coronary artery stenoses than in those without significant stenosis (120.7 ± 16.4 vs 116.7 ± 14.3 mmHg, p < 0.001), lower night-time SBP dip in patients with three or more significant coronary artery stenoses than in those without significant stenosis (5.7 ± 3.2 vs 7.4 ± 6.8 mmHg, p < 0.001) and lower night-time diastolic blood pressure dip in patients with three or more significant stenoses than in patients without significant stenosis (9.4 ± 7.4 vs 11.9 ± 7.4 mmHg, p < 0.001). Night-time SBP values, night-time/daytime SBP dip and extent of significant coronary artery stenosis were risk factors for MACE, revascularization and cardiovascular mortality. In conclusion, the study shows that advanced coronary artery disease is related to blunted night-time BP dipping and cardiovascular complications.
Mace
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Objective To assess the relationship between different pulse pressure indices(PPI) and the severity of coronary artery stenosis. Methods One hundred and fifty-six patients were included. All patients(mean age 59.15±10.60 years, 103 males and 53 females) underwent coronary angiography. Brachial, aortic and 24 h ambulatory systolic blood pressure(SBP),diastolic blood pressure(DBP) were measured before, midst and after coronary angiography. The severity of coronary artery stenosis was evaluated by the number of impaired arteries and Gensini score. Results Patients with essential hypertension(EH) had higher incidence of coronary heart disease(CHD)(73.6% vs 58.5%,P=0.032)than those without EH. Patients with EH had higher incidence of 3 coronary artery lesions(35.2% vs 12.3%,P=0.001)than those without EH. They were all significantly higher in patients with CHD than in the normal subjects for either brachial, aortic or 24 h ambulatory SBP, PP and PPI. Logistic multivariate analysis indicated that PPI were all closely related to the severity of coronary artery lesions. And 24 h ambulatory PPI, compared with other factors, is the better predictor for the severity of coronary artery lesions. Conclusion PPI are all the independent risk factors of the severity of coronary artery stenosis,and the 24 h ambulatory PPI is the better predictor of severity of CHD.
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