Gastrointestinal Mucosal Barrier:Effects of Stress and Intervention
0
Citation
0
Reference
20
Related Paper
Abstract:
Stress can damage tight junction integrity and gastrointestinal mucosal barrier,cause gastrointestinal mucosal barrier dysfunction,and increase the gastrointestinal tract permeability,which ultimately cause the body to produce the inflammatory response.Its intervention can reduce the impact of stress on gastrointestinal permeability.The compositions and functions of gastrointestinal barrier,assessing of gastrointestinal barrier function and measuring of gastrointestinal permeability,and effects of stress on gastrointestinal mucosal barrier and intervention were reviewed in this paper,in order to provide reference for relieving the effects of stress on gastrointestinal mucosal barrier function.Keywords:
Barrier function
Gastrointestinal function
Intestinal Permeability
Cite
Paracellular transport
Barrier function
Claudin
Intestinal epithelium
Intestinal mucosa
Cite
Citations (4)
Most gastroduodenal ulcer disease results from a weakness in the normal gastric mucous barrier against the penetration of acid secreted by the stomach. Based on meticulous and insightful research, the distinguished physiologist Franklin Hollander hypothesized that the stomach is protected against its own acid secretion by a dynamic two-component mucus-mucosal barrier. Hollander and his co-workers defined the physical and chemical characteristics of the mucus components of this barrier, as well as the defense provided by the surface epithelial cell layer, which he viewed as the second line of defense (the second component). Barrier investigators at Mount Sinai demonstrated the effects of impairment of barrier function with resultant increased back-diffusion of acid, and they defined the consequences of this acid penetration into the gastric epithelium. The contribution of these workers included important observations on the natural impermeability of the gastric corpus and fundus as well as the normally increased permeability of the antrum. They also presented evidence on the role of bile in duodenogastric reflux in gastric ulcer disease and the presence of impaired barrier function in patients with gastric ulcer and pernicious anemia. Further studies included demonstration that stress and carcinogens could disrupt the gastric mucosal barrier. Disruption of the barrier, in turn, was shown to allow carcinogenesis to occur by permitting the absorption of certain carcinogens which otherwise are warded off by the barrier. The Hollander two-component gastric mucosal barrier hypothesis has, in recent years, been increasingly validated by experimental data coming from other laboratories.
Barrier function
Bile reflux
Cite
Citations (38)
Schlachter, K.; Kokotilo, M. S.; Ochs, A.; Carter, J.; Thiesen, A.; Churchill, T. A. Author Information
Intestinal Permeability
Cite
Citations (0)
Mucosal Barrier Functions Get access John Bienenstock, M.D. John Bienenstock, M.D. Department of Pathology, McMaster University, Hamilton, Ontario, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar Nutrition Reviews, Volume 42, Issue 3, March 1984, Pages 105–108, https://doi.org/10.1111/j.1753-4887.1984.tb02298.x Published: 01 March 1984
Cite
Citations (6)
Systemic low-grade inflammation can be initiated in vivo after traumatic injury or in chronic diseases such as neurodegenerative, metabolic and autoimmune diseases. Inducers of inflammation trigger production of inflammatory mediators, which alter the functionality of tissues and organs and leads to harmful induction of different barrier systems in the body, where the blood-brain barrier, the blood-retinal barrier, blood-nerve barrier, blood-lymph barrier and the blood-cerebrospinal fluid barrier play major roles. The different barriers are unique but structured in a similar way. They are equipped with sophisticated junctional complexes where different connexins, protein subunits of gap junction channels and hemichannels, constitute important partners. The cells involved in the various barriers are coupled in networks, are excitable but do not express action potentials and may be targets for inflammation leading to changes in several biochemical cellular parameters. During any type of inflammation barrier break-down is observed. In the present review we want to highlight the importance and control of different barriers where any form of injury may lead to systemic inflammation.
Cite
Citations (44)
Cite
Citations (13)
The occurrence and development of dermatoses accompanied by compromised epidermal permeability barrier function are closely associated with oxidative stress. Studies have demonstrated that both the content of oxidative products and the extent of epidermal permeability barrier abnormality correlate positively with the severity of those skin disorders. Administrations of antioxidants can improve both skin disorders and epidermal permeability barrier function. Likewise improving epidermal permeability barrier function can alleviate skin disorders with defective barrier function. In addition, skin aging is also associated with oxidative stress. Aged skin exhibits lower antioxidant capacity and delayed barrier recovery. Topical antioxidants display anti-aging effects. Therefore, approaches of either administering antioxidants or enhancing epidermal permeability barrier function could be helpful in preventing and treating dermatoses accompanied by defective epidermal permeability barrier function. Antioxidants could be useful in slowing skin aging.
Barrier function
Skin Barrier
Cite
Citations (0)
Bacterial translocation
Intestinal mucosa
Barrier function
Lumen (anatomy)
Pathophysiology
Cite
Citations (0)
The intestinal barrier is the largest interface between animal and the external environment,which includes physical barrier,chemical barrier,immune barrier and microorganism barrier.The integrity of intestinal barrier has an important role in preserving health.Many kinds of stress can influence the integrity.The author reviewed the effect of prolonged exercise,restraint stress and heat stress on the intestinal barrier,and the measures to solve it.
Barrier function
Skin Barrier
Cite
Citations (0)
Wattanasiri-chaigoon, S.; Mcnconi, M.; Tomita, M.; Delude, R.; Fink, M. P. Author Information
Hemorrhagic shock
Barrier function
Cite
Citations (0)