[Clinical applications of anti-Müllerian hormone in evaluating ovarian reserve functions].
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Abstract:
Anti-Müllerian hormone (AMH) is a member of the transforming growth factor (TGF)-beta superfamily and mainly expressed by the granulosa cells of ovarian follicles. In women AMH is only expressed in ovarian follicles and therefore can be used for the evaluation of the ovarian reserve function and the prediction of ovary ageing and ovarian response during in vitro fertilization (IVF) treatment. This article summarizes the clinical application of AMH, especially in evaluating ovarian reserve functions.Keywords:
Anti-Müllerian hormone
Ovarian Reserve
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In this paper the role in the ovary of anti-Müllerian hormone (AMH), a member of the transforming growth factor-β family of growth and differentiation factors, is reviewed. AMH has an inhibitory effect on primordial follicle recruitment and may also inhibit follicle-stimulating homone–dependent selection of follicles for dominance. In addition to its functional role in the ovary, AMH in serum is an excellent candidate marker as an indication of the ovarian reserve, not only in infertility clinic patients but also in women during and after cancer treatment.
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Anti-Müllerian hormone (AMH) was originally discovered as the factor responsible for the regression of the Müllerian duct during male sexual differentiation. Through studies of AMH knockout mice, AMH has also been found to regulate primordial follicle recruitment and FSH-dependent cyclic recruitment. However, the details of how AMH influences follicular growth have not been elucidated. Since the early 2000s, when serum AMH concentration was found to be a reliable biochemical marker of ovarian reserve, AMH has been in the spotlight in reproductive medicine. Several studies of AMH have led to new insights on the mechanism of AMH-regulated follicular growth. Here, we review from the earliest studies to the latest findings, AMH regulation of follicle growth with reference to the potential clinical uses of AMH and AMH inhibitors.
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Ovarian Reserve
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Anti-Müllerian hormone
Ovarian Reserve
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Anti-Mullerian hormone (AMH), a dimer glycoprotein secreted by sustentacular cells of testis and ovarian granulosa cells, belonging to the transforming growth factor β super-family. AMH is able to regulate follicular development and participate in follicular growth process, and it is relatively constant throughout the menstrual cycle compared with other ovarian reserve indicators. At present, AMH is widely used to evaluate ovarian reserve and to diagnose and evaluate the development and prognosis of ovarian diseases. It has been increasingly applied in the field of female assisted reproduction in recent years. With the development of detection technology, the sensitivity and accuracy of methods for detecting AMH are gradually improved. This review summarizes the research background, mechanism of action, clinical applications and detecting methods of AMH.
Key words:
Anti-Mullerian hormone; Ovarian function tests; Enzyme-linked immunosorbent assay; Chemiluminescent measurements; Trends
Anti-Müllerian hormone
Ovarian Reserve
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Anti-Müllerian hormone
Ovarian Reserve
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Anti-Müllerian hormone
Ovarian Reserve
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Anti-Müllerian hormone (AMH) is a member of the transforming growth factor beta family of growth and differentiation factors. In the ovary, AMH has an inhibitory effect on primordial follicle recruitment as well as on the responsiveness of growing follicles to follicle-stimulating hormone (FSH). The ovary-specific expression pattern in granulosa cells of growing nonselected follicles makes AMH an ideal marker for the size of the ovarian follicle pool. This review summarizes recent findings concerning AMH and its role as a marker for the quantitative aspect of ovarian reserve as well as ovarian dysfunction.
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Anti-mullerian hormone(AMH) is a member of the transforming growth factor-β superfamily.It is named because it induces muller's duct degeneration in the males.In females,AMH is produced only by granulose cells in preantral and small antral follicles of ovary.Serum AMH level is associated closely with ovarian function,so it is a new marker to evaluate ovarian aging and to predict the ovary responsiveness to ovalution stimulants.In addition,it is related to development and clinical characteristics of polycystic ovarian syndrome.
Anti-Müllerian hormone
Antral follicle
Ovarian Reserve
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Anti-Mullerian hormone(AMH)is ascribed to the TGF-β superfamily and few member known to express in gonad.AMH plays a key role in sex differentiation and follicle recruitment and selection.With the advances in synthesis loci,expression patterns and action mechanism,AMH is served to affect on freemartin,PCOS and PMDS,or marker of ovarian reserve or superovulatory responses.In this paper,the advances in AMH,technological development and application were reviewed.
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Anti-Mullerian hormone(AMH) belongs to the transforming growth factor-β(TGF-β) superfamily,and it plays an important role in male sex differentiation.In women,it is only produced by the granulosa cells(GC) and exerted through specific receptors which are present on the target-organs.AMH level in serum can accurately reflect the size of ovarian follicle pool,so it may be an idea marker of ovarian reserve,and may also be a valuable tool in assisted reproduction technology.More and more investigations show that the elevation of AMH level in serum may be a candidate marker for the diagnosis of granulosa cell tumors and monitor the clinical recurrence of tumor.Moreover,AMH inhibits cell proliferation,invasion and migration of epithelial ovarian cancer cell lines,and it can probably be used as a new drug for chemotherapy in the future.
Anti-Müllerian hormone
Ovarian Reserve
Granulosa cell
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