Forty Cases of Huangkui Capsules Combined with Western Medicine Symptomatic Treatment of Chronic Glomerular Nephritis with Proteinuria
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[Objective]To explore the clinical effect of Huangkui capsule cooperated with conventional symptomatic treatment of chronic glomerular nephritis with proteinuria.[Methods]In addition to conventional therapy,Huangkui capsule has been given to 40 patients with chronic nephritis for 16 weeks.24 hours urinary protein and routine urine test were observed before treatment and 4 weeks,8 weeks,12 weeks and 16 weeks after treatment separately.[Results]After treatment,the patients' urinary protein effectively reduces.The effectiveness increases with the treatment cycle increases.The longer the treatment cycle is,the better effect is.[Conclusion]Huangkui capsule is effective in conventional symptomatic treatment of chronic glomerular nephritis with proteinuria.Keywords:
Nephritis
Capsule
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Objective To analyze the clinicopathological features and prognosis of stage 3-5 chronic kidney disease(CKD) with massive proteinuria.Methods This retrospective study analyzed the presenting features,renal histology and outcome of 174 stage 3-5 CKD patients compare the difference between patients with massive proteinuria(proteinuria≥3.0 g/24 h,group A) and patients without massive proteinuria(proteinuria3.0 g/24 h,group B).Results Compared with group B,there were more patients with stage 4-5 CKD in group A(95.92% vs.86.84%,P0.05) when renal biopsy.Most patients in group A were glomerulonephritis,while few were tubulointerstitial disease and vascular disease.IgA nephritis patients with massive proteinuria had more active lesions.After glucocorticoid or immunosuppressant treatment,24 h proteinuria in group A was decreased [post-therapy vs.pre-therapy:(2.77±1.98)g/24 h vs.(6.21±3.37)g/24 h,P0.01],serum albumin increased [post-therapy vs.pre-therapy:(38.73±5.86)g/L vs.(31.42±7.63)g/L,P0.01],estimated glomerular filtration rate(eGFR) improved [post-therapy vs.pre-therapy:(34.69±26.35) vs.(20.25±6.87)mL·min-1·1.73 m-2,P0.01].Kidney survival of group A was lower(50.75% vs.70.83%,P0.05).Conclusions Stage 3-5 CKD patients need renal biopsy to definite pathological diagnosis when conditions permit.Stage 3-5 CKD patients with massive proteinuria had different clinical presenting features,different pathologic type,more active histological lesions and poorer renal survival rate compare with those without massive proteinuria.Glucocorticoid and immunosuppressant treatment can reduce urokinase protein and improve renal function in renal functionsome patients.Renal biopsy is also necessary for the diagnosis.
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To investigate the effect of benazepril on proteinuria in patients with chronic glomerulonephritis. Methods: A multi-centered and self-controlled study was performed and 64 patients with chronic glomerulonephritis were included. Results:After 12 weeks of treatment, urinary protein decreased by 47. 0 % and 47. 5 % in heavy proteinuria group (30 cases) and in mild proteinuria group (34 cases), respectively. Significant improvement of hypoalbuminemia was found in 14 patients with nephrotic syndrome. Conclusion: Benazepril can significantly decrease proteinuria in patients with chronic glomerulonephritis.
Benazepril
Hypoalbuminemia
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Introduction and aims: N-Acetyl-β-d-glucosaminidase (NAG), a marker of renal tubular dysfunction, is increased in patients with lupus nephritis. In addition to the toxic effects of proteinuria, patients with lupus nephritis may exhibit other factors that contribute to tubular dysfunction, such as pathogenic antitubular basement membrane antibodies. The aim of our study was to assess urinary NAG, proteinuria, and glomerular filtration rate (GFR) before treatment and after 7 and 30 days of oral prednisone therapy in patients with lupus nephritis.
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Objective To explore the effect of huangkui capsule in early and middle stage of diabetic nephropathy patients and the influence for blood lipid.Methods:126 cases with early and middle stage of diabetic nephropathy were randomly divided into control group and experience group.Control group were given routine treatment,and experience group received huangkui capsule therapy.Results The effective rate of treatment in experience group was much higher than that in control group(P 0.05);SCr,BUN,U-β2MG,urinary albumin excretion rate,the total 24 hour urine protein,TG,TC and LDL-C after treatment in experience group were much lower than those in control group(P 0.05);Doppler results showed that Vs and Vd after treatment in experience group were superior to control group(P 0.05).Conclusions Huangkui capsule for early and middle stage of diabetic nephropathy patients greatly improve renal function and renal blood flow,decrease the blood lipid and delay the disease progression.
Capsule
Hyperlipidemia
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Objective: To observe the Chinese medicine clinical treatment effect of chronic nephritis proteinuria.Methods: Gives 66 patients to take the proven prescription of Chinese medicine solid kidney removing extravasted blood treatment,the results of urine protein efficacy,clinical efficacy are better;the average 24-hour urine protein from pre-treatment ( 3.3 ± 2.56) g reduced to ( 1.6 ± 1.2) g after treatment;average blood BUN and Cr have no significant changes before and after treatment.Conclusion: The Chinese medicine treatment chronic nephritis albuminuria has the good curative effect.
Albuminuria
Nephritis
Clinical efficacy
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Objective: To study the effect of irbesartan on decrease proteinuria excretion in chronic glomerulonephritis. Meth-ods:78 cases of chronic glomerulonephritis have taken irbesartan tablets (150mg,qd) to treatment for 12 weeks, and all cases were examined the level of 24-hour-proteinuria before and after treatment 6 weeks,12 weeks. Results: After treatment, the level of 24-hour-proteinuria was significantly decreased . The level of proteinuria decreased from 1. 86g(before treatment) to 1. 46g (after 6 weeks) and 1. 18g (after 12 weeks) ,P0. 01,and the level in 12 weeks was much lower than in 6 weeks(P0. 01). Conclusion: Irbesartan has significant effect on decrease proteinuria in chronic glomerulonephritis patients.
Irbesartan
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The prognosis of Henoch-Schönlein purpura (HSP) nephritis is more severe than originally thought, with a significant portion progressing to deterioration of renal function in adulthood. Proteinuria adversely affects the outcome. The aim of this study was to evaluate the initial single-center results of a treatment protocol for severe HSP nephritis based on the Heaton classification. Age, gender, clinical features and duration of disease follow-up were assessed. Glomerular filtration rate (GFR), urinalysis and 24-hour urinary protein excretion were analyzed. All patients with severe renal involvement were biopsied and a treatment plan was assigned: Class II received oral steroids, Class III (with crescentic nephritis) received additional oral cyclophosphamide 2 mg/kg/d for 12 weeks, and Classes IV and V received azathioprine for 9 months subsequent to the treatment for Class III. All patients received angiotensin converting enzyme (ACE) inhibitors regardless of their blood pressure values. Eighteen patients presenting with severe HSP nephritis, defined as heavy proteinuria and/or decreased renal function, were evaluated. Based on the renal histology, 5, 10, 1 and 2 of the patients were classified as Classes II, III, IV and V, respectively. At presentation, 7 of the patients had impaired renal function with GFR below 75 ml/min/1.73 m2. With the presented treatment schema, all GFR returned to normal at the end of four years of follow-up. There was no proteinuria in any of the patients; only 8 had microscopic hematuria. This preliminary study suggests a stepwise treatment according to the renal histology. The excellent results with complete disappearance of proteinuria and normal renal function justify the use of the aforementioned immunosuppressive protocol with ACE inhibition. Long-term, multicenter controlled studies are needed to verify our results.
Nephritis
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Objective To investigate the therapeutic effects of a self-made prescription Shenluotong in treating IgA nephropathy patients with clinical presentation of prevailing proteinuria.Methods Totally 120 IgA nephropathy patients whose main clinical presentation was proteinuria were randomly divided as trial and control groups.The patients were given,besides the basic treatment,Shenluotong in the trial group,and Lotensin in the control group for 12 months.The effects,symptom scores in Chinese medicine,and indices of glomerular filtration rate (GFR),serum creatinine (Scr),quantity of 24 h urinary protein,and plasma albumin (ALB) were observed before and after the treatment.Results The trial group was better than the control group in effect (P0.01);and so was in symptom score after treatment (P0.01).After treatment the quantity of 24 h urinary protein was decreased and ALB level was increased in the trial group (P0.05);and there were significant differences as compared with the control group (P0.05).Conclusion The Shenluotong can improve the symptom,reduce proteinuria,and protect renal function for IgA nephropathy patients.
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Objective To investigate the efficacy of the clinical treatment and the situation of proteinuria after renal transplantation.Methods 131 patients with proteinuria after kidney grafting were needled biopsy.According to the causes of proteinuria after kidney biopsy,they were treated with glucocorticoid,adjustment of immunosuppressive regimens and improvement of microcirculation.Efficacy of the clinical treatment was then evaluated.Results After treatment,the contents of urinary protein,serum creatinine,rate of creatinine clearance,and the blood urea nitrogen were significantly different(P0.05).There were also significant different between the total efficacy and invalid of rejection,nephritis and ischemic-reperfusion injury after treatment(P0.05).Conclusion According to the causes of proteinuria after kidney biopsy,patients may be treated with glucocorticoid,by adjustment of immunosuppressive regimens or improvement of microcirculation.
Nephritis
Blood urea nitrogen
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Objective:To observe the therapeutic effect of Xiao Si Wu Granules (XSWG)for the treatment of chronic renal disease with proteinuria.Methods:Sixty chronic renal disease patients with proteinuria were equally randomized into two groups:the treatment group received XSWG,and the control group received enalapril.After treatment,the therapeutic effect in the two groups was evaluated. Results:The 24-hour urinary protein volume was decreased and the plasma protein level was increased in the two groups(P0.05).The total effective rate was 93.3% in the treatment group and 70.0% in the control group,the difference being significant(P0.05).Conclusion:XSWG is effective and safe for the treatment of chronic renal disease with proteinuria.
Therapeutic effect
Chronic renal disease
Chronic renal insufficiency
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