The Correlation Study of Artery Blood Gas of Cord Blood and Asphyxia Neonatorum
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Objective:To discuss the correlation study of artery blood gas of neonate cord blood and asphyxia neonatorum.Methods:The artery blood gas of neonate cord blood of 42 cases of asphyxia neonatorum and 42 cases of mormal neonatorum.The levels of pH,PCO2,PO2 and BE between two groups were compared.Results:The levels of pH,PO_2 and BE in asphyxia neonatorum group were significantly lower than those in control group(P0.05),while PCO_2 was significantly higher than that in control group(P0.05).There were no significant differences in pH,PCO_2,PO_2 and BE between neonatal asphyxia group and intrauterine asphyxia grouo(P0.05).Conclusion:The analysis of artery blood gas of neonate cord blood for asphyxia neonatorum can judge the anaerobic condition of neonatorum,which can provide evidence for early anabiosis and salvage and prevent intrauterine asphyxia.Keywords:
Asphyxia Neonatorum
Cord blood
pCO2
Arterial blood
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Cord blood
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Background: Perinatal asphyxia is one of the major causes of neonatal morbidity & mortality. Asphyxia can damage almost every organ of neonate. Our purpose was to determine the correlation of cord blood pH with birth asphyxia & early neonatal outcome. Subjects and Methods: A prospective study was conducted over a period of one year at STH Haldwani. We enrolled 108 term neonates with signs of fetal distress, thick MSL, non-reassuring NST & there were subjected for estimation of umbilical cord blood pH, APGAR score, outcome looked were resuscitation needed, NICU admission, delay in feed & encephalopathy (sarnat & sarnat stage). Results: In our study, cord blood pH had significant correlation with perinatal asphyxia(R=-0.926). Area under ROC curved showed that mean pH <7.1 (ROC=0.998) is very significant in predicting the adverse outcome. Conclusion: Cord blood pH is very sensitive and specific & has good correlation in predicting the birth asphyxia & adverse neonatal outcome. Measurement of cord blood pH is recommended in all the neonates with signs of fetal distress.
Apgar score
Cord blood
Perinatal asphyxia
Neonatal Resuscitation
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A method for serial sampling of umbilical artery blood was described in a previous report. Another study using this method demonstrated that the umbilical artery blood becomes more asphyxial over the first 20 sec after birth, even though up to 5 breaths occurred over this time. In the present study, serial samples of umbilical artery blood were function obtained at slightly later intervals; the first samplings occurred at 11–41 sec and the second samplings at 22–59 sec. From 3 to 11 breaths occurred between birth and the second sampling. Unlike the results in the prior study, many infants showed a rising pH, a falling PCO<sub>2</sub>, and a rising oxygen saturation from the first to the second sampling. When the results of one of the prior studies are combined with the present study, it appears that the fifth breath represents the approximate point of reversal of the trend from one of increasing asphyxia to one of improvement in blood gas values. The fifth breath usually occurred at 20–30 sec. It may be advantageous to allow the placental respiration to continue until the pulmonary respiration becomes effective by delaying cord clamping until 5 breaths have occurred or until 30 sec have elapsed.
Umbilical artery
Asphyxia Neonatorum
Blood sampling
Arterial blood
Oxygen Saturation
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Umbilical cord blood gas values are better indicators of perinatal asphyxia than Apgar scores. Many studies have reported normal ranges of umbilical cord blood gases, which vary greatly due to many factors. This study aimed to establish the reference values of umbilical cord blood gases of normal cesarean newborns in a university hospital setting.Blood samples from the umbilical artery and vein were collected from 160 newborns delivered by elective cesarean section. The indications for caesarean section were not due to fetal distress, intrauterine growth retardation, or non-reassuring fetal heart rate. The blood samples were collected immediately after birth in the operating room and then sent for blood-gas analysis. The blood-gas values were statistically analyzed and reported.The cord blood collected from 160 newborns was analyzed in this study. Seventy-eight percent (115) of the parturients were hypotensive before delivery. All Apgar scores at one and five minutes after delivery were at least 7. The calculated reference range of the umbilical arterial pH was 7.18-7.42, of pO₂was 6.43-29.43 mmHg, of pCO₂was 33.44-66.56 mmHg, and of HCO₃was 15.60-30.70 mEq/L. The reference range obtained for the umbilical venous pH was 7.28-7.44,for pO₂was 13.97-37.13 mmHg, for pCO₂was 30.70-57.0 mmHg, and for HCO₃was 18.50-29.90 mEq/L.The study determined normal reference values as a result of umbilical cord blood gas analyses.
Umbilical artery
Apgar score
Arterial pH
Venous blood
Arterial blood
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Objective:To explore the clinical application value of blood gas analysis of umbilical artery in the diagnosis of neonatal asphyxia.Methods:147 neonates were selected,blood gas analysis of umbilical artery was conducted at birth,and Apgar score was performed at one minute after birth,all the neonates were divided into ≥8 group,4～7 group and ≤3 group,and the related data of blood gas analysis of umbilical artery were analyzed.Results:There was a significant correlation between pH,PO2,PCO2,BE of umbilical artery and Apgar score;and there was significant difference among different groups;there was significant difference in umbilical artery blood pH7.20 or pH7.25 among different groups.Conclusion:Blood gas analysis of umbilical artery is an objective and reliable inspection indicator,which can make up for the deficiencies of Apgar score and improve the diagnosis rate and cure rate of neonatal asphyxia.
Umbilical artery
Apgar score
Blood gas analysis
pCO2
Arterial blood
Gas analysis
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Cord blood
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To analyse the results of ICP neonatal umbilical artery blood gases and study neonate hypoxia and acidosis.Neonatal blood gases (pH?BE?PO 2?PCO 2) of 35 cases ICP (study group) and 142 neonates of normal pregnancy(control group) were measured.pH,BE in the study group were 7.26±0.16 ,-8.95±0.60, respectively,while those in the control group were 7.26±0.07 , -6.76±0.03, respectively, there were significant differences in pH,BE(P0.001,P0.05), respectively.[Conclusion]pH and BE of ICP neonates decrease. The neonate shows symptoms of oxygen deficit and acidosis,so ICP should be effectively treated, pregnancy be terminated in time and cesarean section should be considered. A routine analysis of neonatal umbilical artery blood gases should be made and the neonate be treated as soon as possible.
Umbilical artery
Blood gas analysis
Arterial blood
Hypoxia
Arterial pH
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Objective To study the umbilical arterial blood gas reference values of newborns and to guide diagnosis and treatment of the premature infants.Methods Three hundred and ninety-eight full-term newborns in our hospital were included in the study.Their umbilical arterial blood gas value was measured within 1 min after birth.The correlation among the umbilical arterial blood gas value,Apgar score and organ damage was analyzed.Results With the lower pH value,the incidence of neonatal organ injury gradually increased.pH value of umbilical arterial blood and Apgar were significantly and negatively correlated with hypoxic organ damage.The lower the pH and Apgar values were,the higher the incidence of organ damage was.Conclusion Low Apgar score with umbilical arterial pH less than 7.0 help the diagnosis of neonatal asphyxia.Blood gas analysis is one of the key indicators for the diagnosis of premature infants.
Apgar score
Arterial blood
Arterial pH
Blood gas analysis
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Background: Perinatal asphyxia may be caused by perinatal anemia. The pathophysiology and neurodevelopment effects are theoretically different from other causes of fetal asphyxia. Severe asphyxia can occur in infants around the time of birth by various reasons. The aim of this study to find the relationship between cord blood hemoglobin and perinatal asphyxia.Methods: This was a retrospective comparative study in department of OBG In tertiary care health centre. Umbilical cord blood samples were collected from 100 newborns with asphyxia at birth as study group and 100 newborns with non asphyxia as control group. Hemoglobin was measured colorimetrically.Results: This study finds that maximum number of patients in both the control and study group had hemoglobin in the range of 16.3-17.3 gm/dl. The difference was not statistically significant. P value>0.05.Conclusions: Hematological changes observed early after delivery can determine the duration of hypoxemia (acute versus chronic) Perinatal anemia causing moderate to severe perinatal asphyxia is associated with a higher risk for neonatal mortality. All survivors with perinatal anemia, however, showed no abnormalities in neurodevelopment in contrast to children who were born asphyxiated due to various another causes. The underlying pathophysiological mechanism for the favorable NDO in the perinatal anemia group needs further elucidation.
Perinatal asphyxia
Cord blood
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