Efficacy analysis of Perindopril combined with Indapamide in primary hypertension
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Objective:To investigate the hypotensive effect and adverse reactions of Perindopril combined with Indapamide in primary hypertension.Methods:From July 2009 to December 2009 in our department,90 patients diagnosed with essential hypertension were randomized groups,46 cases of treatment group and 44 cases of control group,they were excluded secondary hypertension.These patients stopped taking antihypertensive drugs more than 5 days.Before and after treatment,the blood and urine routine,ECG and blood lipids,blood glucose,liver and kidney function were recorded.The control group treated with Indapamide 2.5 mg/d or 5 mg/d;the treatment group treated with Indapamide 2.5 mg/d and Perindopril 4 mg/d;the curative effect were assessed after 8 weeks.Results:The total effective rate of treatment group was 87.0%,and the control group was 59.1%,the difference was statistically significant(P0.05),and the treatment group had less adverse reactions.Conclusion:Perindopril combined with Indapamide in the treatment of primary hypertension has good effect and less adverse reactions,it is worth popularizing.Keywords:
Indapamide
Perindopril
Essential hypertension
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Objective:To evaluate the safety and efficiency of bisorpolol (5mg, Qd) and indapamide (2.5 mg, Qd) combination therapy in treating patients with mild to moderate essential hypertension. Methods: Sixty patients with mild to moderate essential hypertension were randomly divided into 2 groups (A and B). Patients in group A took bisoprolol (5 mg, Qd) combining with indapamide (2.5 mg, Qd), and patients in group B took indapamide (2.5mg, Qd) only for 8 weeks. All the patients were finished the trial. Blood pressure (BP) and biochemical markers were observed. Results: At the 8th week, thirteen patients had evident effect and fourteen patients had effect in group A, correspondingly, there was seven patients and sixteen patients in group B;The total antihypertensive effective rate was 90.0% in group A and 76.7% in group B. The difference had statistical significance (P 0.05). The biochemical markers were not statistically significant before and after treatment. The incidence of side effects in the two groups were similar. Conclusion: Combination of bisorpolol and indapamide is not only effective and safe, but also no any influence on metabolism of lipids and glucose in treating patients with essential hypertension.
Indapamide
Essential hypertension
Group B
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Objective: To analysis the clinical effects and feasibility of indapamide combined with enalapril in the treatment of diabetic mellitus complicated with hypertension. Methods: A total of 70 cases in our hospital were divided into control group and observation group. Patients in the control group were treated with enalapril,and patients in the observation group were treated with indapamide combined with enalapril. The level of blood glucose,serum potassium,blood pressure and effects were observed. Results: There are no significant difference on the level of blood potassium and blood glucose in the two groups( P 0. 05). After treatment,the blood pressure in the observation group was lower than that of the control group( P 0. 05). The total effective rate was 85. 71% in the observation group,and 65. 71% in the control group. The differences between the two groups were statistically significant( P 0. 05). Conclusion: Indapamide combined with enalapril has remarkable effect for the treatment of diabetes mellitus complicated with hypertension.
Indapamide
Essential hypertension
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Objective To evaluate the therapeutic effects of enalapril combined with indapamide in the treatment of diabetes accompanied with hypertension. Methods Sixty-four patients were chosen according to the diagnostic criterions of diabetes and hypertension made by WHO and WHO/ISH respectively in 1999. The patients were divided into Group A(test group) and Group B(control group) randomly. Group A was given enalapril (10 mg) and indapamide (2.5 mg ) per day for 12 weeks. Group B was treated with enalapril (10mg) per day for 12 weeks. Blood pressure was measured by mercury sphygmomanometers at the same time of different days before, during and after the treatment. Liver function, renal function, cardiogram and HbA1c were measured both before and after the treatment. Results For the blood pressure, there was a highly significant difference before and after the treatment in Group A, P0.01, and there was a significant difference between Group A and Group B after the treatment,P0.05. For the therapeutic effects, there was a significant difference between Group A and Group B, P0.05. Conclusions Enalapril combined with indapamide has better effects and fewer side effects compared with the single drug in the treatment of diabetes accompanied with hypertension. The combination therapy can control the blood pressure to an expected aim value.
Indapamide
Therapeutic effect
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Objective:To observe the efficacy,safety and feasibility of valsartan combined with indapamide treatment of essential hypertension. Method:118 patients with essential hypertension were randomly divided into a treatment group and the control group of 59 cases. Valsartan treatment group using valsartan combined with indapamide control group,effects were observed after 8 weeks.Result:Treatment group total effective rate was 91.5%,control group total effective rate was 78.0%,there was significant difference between the two groups meaning( P 0.05).Conclusion:Valsartan combined indapamide treatment of primary hypertension efficacy significantly fewer adverse reactions,safe and reliable,good compliance.
Indapamide
Essential hypertension
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Objective: To explore the effect of combined therapy with valsartan and indapamide on senile hypertension.Methods: A total of 81 cases with senile hypertension admitted from Jan.2008 to Jan.2010 were randomly divided into observation group(41 cases) and control group(40 cases).All patients had drug withdrawal for more than 1 week.Patients in control group were treated with valsartan 80 mg per day for 4 weeks,and observation group with indapamide 1.25 mg per day for 4 weeks.Results: Diastolic and systolic pressure and total efficiency in observation group were significantly different from those in control group(P0.05).Conclusions: Combined therapy with valsartan and indapamide is effective on treatment of senile hypertension.
Indapamide
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Indapamide
Perindopril
Fixed-dose combination
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SummaryA single-blind, multicentre trial was carried out in 251 patients with essential hypertension to assess the effectiveness and tolerance of treatment with indapamide. After a 2-week period on placebo, patients received 2.5 mg indapamide daily, as a single dose, for a further 2 months. The results showed that there was little change in blood pressures after placebo but a significant reduction in systolic and diastolic blood pressure, both in supine and standing positions, after indapamide. Adequate blood pressure control was achieved with indapamide alone in 63 % of the 138 patients with mild hypertension, and in 52% of those with moderate hypertension. Non-limiting side-effects were observed in only 7 patients, and there were no significant biochemical changes except for a statistically significant but slight decrease in sodium, potassium, chloride, and calcium levels.
Indapamide
Supine position
Essential hypertension
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Objective:To investigate the clinical efficacy and prognosis for diabetic hypertension among old patients by combined treatment of candesartan and indapamide.Methods:A treatment group and a contrast group were formed randomly by 150 cases of old patients which were diagnosed diabetic hypertension.The treatment group(78 cases) were remedied by candesartan and indapamide,meanwhile the contrast group(72 cases) were remedied by nifedipine controlled release tablets and indapamide.After treatment for 12 weeks,comparison was made for range and effect of drop of blood pressure,therapeutic efficacy for drop of blood glucose,heart rate,serum potassium,sodium as well as total cholesterol.And 12 months later,revisit was made to the occurrence of cardiovascular and cerebrovascular disease.Results:Therapeutic efficacy for drop of blood glucose excelled in treatment group,and rate of occurrence for cardiovascular and cerebrovascular disease was lower in treatment group(P0.05);But both groups have significant antihypertensive effects(P 0.01),Differences between groups hypotensive effect was not statistically significant(P 0.05);variation of heart rate,serum potassium,sodium and total cholesterol in both two groups was not noticeable before and after therapy.Conclusion:The combined treatment of candesartan and indapamide is comparably better for agedness diabetic hypertension.
Indapamide
Candesartan
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Objective:To evaluate the efficacy and tolerability of perindopril (2 mg) and indapamide (0. 623 mg) compound versus indapamide sustained-released tablets in patients with mild to moderate hypertension. Methods: A randomized, double blind, multicenter,parallel control clinical study enrolled 231 patients (aged 18 to 65 years old) with essential hypertension (95 mmHg≤sitting DBP 115 mmHg and SBP 180 mmHg). After the patients experienced a 2-week washed out period, they were randomized to administer either perindopril 2 mg / indapamide 0. 625 mg (n = 116) compound or indapamide SR 1. 5 mg alone ( n = 115 ) once daily for 6 weeks. At the end of this 6-week course of therapy, patients with sitting DBP 90 mmHg continued the medication regimen, and patients with sitting DBP≥95 mmHg were tapered onto the perindopril 4 mg / indapamide 1. 25 mg compound once daily in the bi-therapy group or received an added-on therapy with indapamide SR 1. 5 plus metoprolol 50 mg once daily in the mono-therapy group for additional 6 weeks. Patients underwent an ABPM pre-treatment and post the 12-week course of therapy. Results:52 out of the 107 patients (48. 6% ) tapered the drug regimen up in the bi-therapy group and 52 out of the 96 patients (54. 2% ) received the adjunctive therapy in the mono-therapy group after the first 6-week course of the therapy; the P value of changing drug regimens in the bi-therapy and the mono-therapy group showed no statistical difference ( P = 0. 43 ). The patients in the bi-therapy and added-on-therapy experienced a reduction of DBP ( average down value 12.4 mmHg versus 13.6 mmHg,P =0. 191 ) and a decrease of SBP (average down value 15.4 mmHg versus 15. 7 mmHg) at the end of the second 6-week course of therapy. The ABPM values showed significant improvements during the treatment in both groups. The mean trough/peak ratio (TPR) of DBP in the bi-therapy and added-on-therapy group was 80% and 47% , respectively. Common adverse events included cough, rhinitis and hypokalaemia. No significant difference was found in the incidence rate of these adverse events in patients with bi-therapy and added-on-therapy. Conclusion: The perindopril and indapamide compound offered an alternative therapy for patients with hypertension.
Indapamide
Tolerability
Perindopril
Regimen
Combination therapy
Essential hypertension
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Objective To explore the clinical effect of indapamide combined with enalapril tablets in the treatment of essential hypertension. Methods 95 patients with essential hypertension treated in our hospital from September 2012 to September 2013 were selected and randomly divided into treatment group( n=48) and control group(n=47),he control group wwa treated with indapamide,while the treatment group was treated with indapamide combined with enalapril tablets.The therapeutic effects of the two groups were compared. Results The efficiency and total efficiency of the treatment group were significantly higher in comparison with the control group, statistically difference existed( P0.05);The diastolic blood pressure improvement from the treatment group was also significantly higher compared with the control group with statistically difference existed(P0.05). Conclusion Indapamide combined with enalapril tablets have obvious clinical efficacy in the treatment of essential hypertension,and this kind of treatment method has notable features as easy to access,small chance of occurrence of adverse symptoms,sound patient compliance.
Indapamide
Essential hypertension
Clinical efficacy
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