0165 : Evaluation of the lipid profile in the cardiovascular risk in patients with systemic lupus erythematosus
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Dyslipidemia
Lipid Profile
Objective To investigate the epidemiologic features of some forms of dyslipidemia in communal hypertensive adults in Wujiaochang Community of Shanghai.Methods A cross-sectional survey was conducted through a cluster multistage sampling of a resident group of 1 842 hypertensive individuals(853 men and 989 women,aged≥40 years) in Shanghai.The cutpoints of lipid phenotypes were based on the1992 recommendations of the European Atherosclerosis Society.Results The most prevalent abnormality(35.3%) was isolated hypercholesterolemia(33.6% for men and 36.8% for women).Mixed dyslipidemia was the secondary prevalent abnormality(15.9%).Isolated hypertriglyceridemia was observed in 6.1% of the sample.The prevalence of normotriglyceridemic hypoalphalipoproteinemia and severe dyslipidemia was 2.5% and 3.7%,respectively.Only a few samples had the abnormality of hypertriglyceridemia/hypoalphalipoproteinemia(0.7% for men and 0.4% for women).The prevalence of isolated hypertriglyceridemia,mixed dyslipidemia,and severe dyslipidemia was higher in diabetic patients compared with non-diabetic patients.Compared with those of normal weight,obese patients had a higher prevalence of isolated hypertriglyceridemia,mixed dyslipidemia,hypertriglyceridemia/hypoalphalipoproteinemia and severe dyslipidemia.Conclusion The prevalence of dyslipidemia among these hypertensive patients was relatively high.Diabetes and obesity,the modifiable risk factors,increased the likelihood of dyslipidemia.
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Objectives: This study will help us to understand what lipid profile is normally present in our population, if abnormal, timely screening, education, and proper management can be done. Study Design: Cross-sectional study. Setting: Jinnah Postgraduate Medical Centre (JPMC), Karachi, Pakistan. Period: November 2018-April 2019. Material & Methods: For the lipid profile, intravenous blood samples were collected in testing bottles after overnight fasting of 9-12 hours and sent to the institutional laboratory for testing. Dyslipidemia was defined as abnormal levels of any of the following components of the lipid profile. Total cholesterol of <200mg/dL was considered “desirable” while that of >240mg/dL was termed as hypercholesterolemia. High-density lipoprotein (HDL) was considered as “low” when it was <40mg/dL while Low-density lipoprotein (LDL) was considered as “optimal” when it was less than 100 mg/dL. Triglycerides level >150 mg/dL was identified as hypertriglyceridemia. We defined isolated dyslipidemias as abnormal levels of any of these. This study was assessed and approved by the institutional review board of JPMC. Results: 112 participants of age <40 and >20 years were registered with 62 males and 50 females. Prevalence of dyslipidemia was found to be 75.9% with significantly high percentage in females (p < 0.05). 55.4% of the participants had desirable serum cholesterol and 42.9% had hypertriglyceridemia. 58% of these had HDL levels <40 mg/dL while 18.8% had high LDL levels. The mean serum cholesterol was significantly different in males and females (p=0.018). 7.1% of the total had isolated hypertriglyceridemia, 18.8% had isolated low HDL levels, and 46.4% had mixed hyperlipidemia, with significant differences between males and females in the former two. Conclusion: Dyslipidemia is a major risk factor for numerous systemic disorders and should be detected early in life for an effective management prior to the appearance of symptoms. This study gave a high prevalence of dyslipidemia in asymptomatic young adults, with females being more frequently affected than females.
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Background. Dyslipidemia is one of the major modifiable risk factors for the development of cardiovascular disease and type two diabetes mellitus. Knowing the current prevalence of dyslipidemia is an important step for increasing awareness of the problem and for proper planning of health programs for prevention of its negative clinical effects. Methods. A national population based household sample was selected from north, middle, and south regions of Jordan in 2017. A total sample of 4,056 aged between 18 and 90 years were included. Selected individuals were interviewed using a structured questionnaire and fasting blood samples were collected for biochemical measurements. Results . The prevalence rates of hypercholesterolemia, hypertriglyceridemia, high LDL, and low HDL were 44.3%, 41.9% 75.9%, and 59.5%, respectively. Hypercholesterolemia in Jordan almost doubled from 23.0% in 1994 to 44.3% in 2017, and hypertriglyceridemia increased from 23.8% in 1994 to 41.9% in 2017. All lipid abnormalities decreased after the age of 60 years. Hypertension, diabetes, and obesity were all independently associated with hypercholesterolemia and hypertriglyceridemia. Conclusions. Results of this study show that dyslipidemia is a widely prevalent health problem among adult Jordanian population and that the problem has substantially increased since 1994. Encouraging healthy lifestyle and healthy diet are the basis for prevention of dyslipidemia.
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Objective To investigate the prevalence of dyslipidemia of retired employees in Xiangshan County,Zhejiang Province and to provide basis for the further study,prevention and cure of dyslipidemia.Methods The investigation was carried out from September 1 to October 19,2008.Fasting plasma levels of total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C) and low-density lipoprotein cholesterol(LDL-C) were determined with the enzyme methods.Results The crude prevalence of dyslipidemia of retired staff in Xiangshan was 26.9%(23.9% for males and 30.0% for females).The prevalences of hypercholesterolemia,hypertriglyceridemia,low blood HDL-C,and high blood LDL-C were 14.6%,9.4%,2.0%,9.0%,respectively.The prevalences of borderline high TC,TG and LDL-C were 34.9%,12.5%,14.8%,respectively.Conclusion Dyslipidemia,especially hypercholesterolemia,has become one of important risk factors threatening health of the retired employees in Xiangshan.Hypercholesterolemia and high blood LDL-C were two major types in the females,and hypercholesterolemia and hypertriglyceridemia in males.It is vitally important to the health of retired employees to pay attention to prevention and treatment of borderline high TC,TG and LDL-C.
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To study the difference in prevalence of dyslipidemia, hypercholesterolemia, hypertriglyceridemia and low blood high-density lipoprotein cholesterol (HDL-C) between the residents of urban and rural areas of varied regions in China.Fasting plasma levels of total cholesterol, triglyceride and HDL-C were determined with the enzyme methods for 49,252 subjects aged 18 and over during August to December, 2002.Prevalence of dyslipidemia in Chinese adults aged 18 and over was 18.6%, with 17.0%, 22.9% and 23.4% in the groups of 18-44, 45-59 and over 60 years old, respectively, 22.2% and 15.9% in males and females, respectively, and 21.0% and 17.7% in urban and rural areas, respectively. Prevalence of hypercholesterolemia, hypertriglyceridemia and low blood HDL-C in those aged 18 and over was 2.9%, 11.9% and 7.4%, respectively.Dyslipidemia has become one of important risk factors threatening health of Chinese people, with hypertriglyceridemia and low blood HDL-C as two major types in those aged 18 and over. Prevalence of dyslipidemia was nearly the same in the middle-aged and in the elderly people, and not significantly different in those living in urban areas from those in rural areas. It is very important to pay more attention to earlier comprehensive prevention and control of dyslipidemia.
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Dyslipidemia is an important, modifiable CHD risk factor. Previous studies have reported the prevalence of dyslipidemia particularly in urban populations. However, its prevalence in rural Northeast Thailand has not been well documented since extensive dietary and lifestyle transitions induced by the rapid socio-economic development of the late 1990s and early 2000s. The authors, therefore, conducted a cross-sectional assessment for the prevalence of dyslipidemia among rural Thais (in Khon Kaen province) using the National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP III) Guidelines. The 325 subjects recruited (136 men; 189 women) averaged 53.8 +/- 17.6 years of age (range, 20-88). After having the subjects fast 12 hours, serum samples were collected. Total cholesterol, triglycerides, low-density lipoprotein (LDL-C) and high-density lipoprotein (HDL-C) cholesterols were measured. The prevalence of hypercholesterolemia (> 200 mg/dL), hypertriglyceridemia (> 150 mg/dL), high LDL-C (> 130 mg/dL) and low HDL-C (< 40 mg/dL) was 31, 40, 20 and 14 per cent, respectively. Women had a 2- to 3.5-fold higher prevalence of hypercholesterolemia and high LDL-C than men, while the prevalence of hypertriglyceridemia was comparable. The prevalence of dyslipidemia increased with advancing age and increasing BMI; notwithstanding, a high prevalence of dyslipidemia was observed in the youngest tertile as well. In conclusion, the present study demonstrated a high prevalence of dyslipidemia in rural Thai adults; consequently, primary lipid screening should be considered for all ages.
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Cross-sectional study
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Dyslipidemia is the most important modifiable risk factor that leads to cardiovascular diseases. The screening for dyslipidemia in Palestine is not established in primary health care centers for healthy people. Our study aims to determine the prevalence of dyslipidemia among healthy undiagnosed adult men in Palestine in order to assess the need for screening and preventive programs for dyslipidemia.A cross-sectional observational study was carried out in 10 secondary schools at Nablus municipality (Palestine) from August 2017 to February 2018. The study included 140 teachers based on sample calculations. The age of participants ranged between 24 and 60 years. A questionnaire was used to collect demographic data about the lifestyle, past medical, and family histories. Serum lipid profile, and fasting blood glucose levels for each participant were measured. Lipoprotein levels were categorized based on the adult treatment panel III criteria.The overall prevalence of dyslipidemia among Palestinian men was 66.4%. The most prevalent type of dyslipidemia was hypo HDL (X < 40 mg/dl, 59.3%), followed by hypertriglyceridemia (X ≥ 200 mg/dl, 20%). The prevalence of hyper LDL (X ≥ 160 mg/dl), hypercholesterolemia (X ≥ 240 mg/dl) was 8.5%, and 3.6%, respectively. About 15% of participants had glucose intolerance, and 4.3% had hyperglycemia (undiagnosed). Those with glucose intolerance, 13 (9.2%) have hypo HDL, while 9 (6.42%) have hypertriglyceridemia. On the other hand, out of hyperglycemic patients: 5 (3.5%) had hypo HDL, and 1 (0.7%) had hypertriglyceridemia.Around two-thirds of undiagnosed participants had at least one lipid abnormality. None of them were aware of having dyslipidemia. The prevalence of undiagnosed dyslipidemia was higher than the prevalence of undiagnosed glucose intolerance, and diabetes. This suggests that dyslipidemia plays a major role in developing diabetes. Hence, profound efforts should be done to manage and treat those with dyslipidemia, in order to prevent progression to type II diabetes mellitus.
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Cross-sectional study
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Objective To study the clinical characteristics of abnormal lipid metabolism in different types of elderly people with hypertension.Methods The clinical data,collected from the elderly people who underwent annual physical examination,the characteristics of dyslipidemia and abnormal lipid metabolism in different types of elderly people with hypertension were analyzed retrospectively. Results The prevalence of dyslipidemia was 69. 63％, in which the prevalence of hypercholesteremia and hypertriglyceridemia was 23. 65％, and 26. 71％ respectively. The prevalence of hypercholesteremia accompanied hypertriglyceridemia( mixed group) was 19. 27％, and normal group was 30. 37％. Hypertriglyceridemia group was easier to be accompanied with hypertension than normal group and HTC group(P ＜0. 05). The hypertriglyceridemia had higher risk of cardiovascular and cerebrovascular diseases than norral group and HTC group( P ＜ 0. 05 ). Conclusion The elderly people had high prevalence of dyslipidemia and metabolic syndrome,and with high prevalence of hypertension, which led to higher risk of cardiovascular and cerebrovascular diseases. The hypertriglyceridemia had more strong impact on cardiovascular and cerebrovascular diseases than hypercholesteremia.
Key words:
Abnormal dyslipidemia metabolism; Hypertension; Elderly
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Objective: To determine the frequency for pattern of dyslipidemia in patients with chronic kidney disease. Study Design: Descriptive, cross-sectional Place and Duration of Study: Department of Nephrology, Jinnah Postgraduate Medical Centre (JPMC) from 26th December 2018to 28thJune 2019. Methodology: One hundred and thirty-two patients were enrolled. Blood sample of 5 ml of each patient was taken and sent to the institutional pathology laboratory for measurement of lipid profile and pattern of dyslipidemia i.e. high cholesterol, low HDL, high LDL, hypertriglyceridemia was noted. Results: The mean age was 44.68±9.39 years and mean of duration of chronic kidney disease was 5.13±2.19 months. Seventy eight (59%) were males and 54 (41%) were females. Pattern of dyslipidemia i.e. high cholesterol, low HDL, high LDL and hypertriglyceridemia were documented in 89 (67.4%), 61 (46.2%), 65 (49.2%) and 37 (28.0%) patients respectively. Conclusion: Dyslipidemia is common among patients with chronic kidney disease is considerable. Regular evaluation of all chronic kidney disease patients for dyslipidemia and treatment need to be instituted. Key words: Dyslipidemia, Chronic kidney disease (CKD), Cholesterol, Low density lipoprotein (LDL), High density lipoprotein (HDL), Hypertriglyceridemia
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Nephrology
Lipid Profile
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ABSTRACT
Introduction: The Dyslipidemia is characterized by elevated levels of blood
lipids, particularly triglycerides and cholesterol. In its evolution, this condition
determines a high risk of cardiovascular disease. In Brazil there are few surveys
dyslipidemic behavior in blacks. In this context, the quilombo communities
represent an important research setting for research in this area. This study
aims to determine the prevalence of dyslipidemia in the quilombo communities
of Codo-MA, and the factors associated with this condition. Methods: This
cross-sectional, descriptive and analytical study based on socio-demographic
data and clinical evaluation. The selected population is made up of 200
individuals from 21 years of age. For Dyslipidemia classification criteria of the V
Brazilian Guidelines on Dyslipidemia and Prevention of Atherosclerosis will be
used. Results: The prevalence of dyslipidemia in the sample was 72.28%, with
38.61% presenting hypertriglyceridemia isolada.Dentre the dyslipidemic,
60.27% are female and 94.52% have education less than 5 years of study. As
for the nutritional classification, 34.25% of dyslipidemic are overweight, 13.70%
and 58.22% are obese have abnormal waist circumference. Regarding life
habits, 43.84% are smokers and 57.24% of them are alcoholics. There was
dyslipidemia association with hypertension, smoking and metabolic syndrome.
Conclusions: The study showed prevalence of dyslipidemia among quilombola
descendants, mostly female and aged 40 to 49 years, with a predominance of
isolated hypertriglyceridemia.
Dyslipidemia
Cross-sectional study
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