logo
    Hepatitis B virus transactivator MHBst: activation of NF-kappa B, selective inhibition by antioxidants and integral membrane localization.
    The EMBO Journal (1992)
    Markus MeyerWolfgang H. CaselmannVolker SchlüterRalf SchreckP. H. HofschneiderPatrick A. Baeuerle
    204
    Citation
    71
    Reference
    10
    Related Paper
    Citation Trend
    Keywords:
    Kappa
    Topics:
    Genomics, phytochemicals, and oxidative stress
    Hepatitis B Virus Studies
    NF-κB Signaling Pathways
    PDF
    LEVELS OF IL-10 ALTER NF-KAPPA B ACTIVATION THROUGH REGULATION OF I KAPPA KINASE (IKK) IN BOTH HUMAN AND MOUSE CELL TYPES
    Critical Care Medicine (2002)
    Randall M. SchwartzBin ZhaoAlvin DenenbergThomas P. Shanley
    SOCIETY OF CRITICAL CARE MEDICINE 32ND CRITICAL CARE CONGRESS SAN ANTONIO, TEXAS, USA JANUARY 28-FEBRUARY 2, 2003: ORAL/SANDWICH PRESENTATIONS: Poster Presentation: Basic Science: Sepsis Signal Transduction: PDF Only
    Kappa
    IκB kinase
    Citations (0)
    Abstract 11429: Development of Spontaneous Myocarditis in Nuclear Factor kappa B (NF{kappa}B) p50-Deficient Mice: the Emerging Role of NF{kappa}B p65 in its Pathogenesis
    Circulation (2012)
    Milan GautamAtsushi IzawaYuji ShibaYuchihiro KashimaJun Koyama
    Background: The transcriptional factor NFκB plays a pivotal role in triggering inflammation and autoimmune responses. We observed spontaneous development of myocarditis in NFκB p50-deficient NOD mi...
    Kappa
    Pathogenesis
    Citations (0)
    Activation of TWIST1 by COL11A1 decreases cell sensitivity to paclitaxel by modulating NF kappa B -mediated I kappa kappa beta expression
    Cancer Research (2017)
    Yi-Hui WuCheng-Yang Chou
    Kappa
    BETA (programming language)
    Citations (0)
    VEGF EXPRESSION IN HUMAN MACROPHAGES IS NF kappa B-DEPENDENT: STUDIES USING ADENOVIRUSES EXPRESSING A KINASE DEFECTIVE FORM OF IKK2 or I kappa B alpha THE NATURAL NF kappa B INHIBITOR
    Lara D. Veeken (2002)
    Serafim KiriakidisEvangelos AndreakosC MonacoBrian M. J. FoxwellMarc Feldmann
    Kappa
    IκB kinase
    Alpha (finance)
    Citations (1)
    Targeting I kappa B Proteins for HIV Latency Activation: the Role of Individual I kappa B and NF-kappa B Proteins.
    Journal of Virology (2013)
    Guerau FernándezThomas D. ZaikosSohrab KhanAshley M. JacobiMark A. Behlke
    Kappa
    Citations (0)
    Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.
    Genes & Development (1995)
    Inder M. VermaJennifer K. StevensonEdward M. SchwarzDaniel Van AntwerpShigeki Miyamoto
    The growth, differentiation, and development of an organism is orchestrated by the choreographed expression of a wide array of genes.The switching "on" and "off" of gene expression is the province of transcription factors, which operate singly or in association with other proteins.Usually transcription factors form families, whereas individual members perform specific, distinct, or similar tasks.One such family includes the R ~~/ N F -K B proteins (NF-KB), which have the unique property of being sequestered in the cytoplasm in association with inhibitory proteins called IKB.Activation and regulation of NF-KB are tightly controlled by IKB proteins.Through noncovalent association, the IKB proteins mask the nuclear localization signal (NLS) of NF-KB, thereby preventing NF-KB nuclear translocation.Upon stimulation with signaling molecules such as tumor necrosis factor a (TNFa) or lipopolysaccharide (LPS), NF-KB is released from IKB and translocated to the nucleus where it regulates gene transcription.Stimulation and activation of the NF-KB transcription factors do not require protein synthesis, thereby allowing rapid and efficient activation of target genes.This system is particularly utilized in immune, inflammatory, and acute phase responses where rapid activation of defense genes following exposure to pathogens such as bacteria and viruses is critical for survival of an organism.Many pathogenic viruses have evolved enhanced viral replication by including NF-KB target sites in their promoterlenhancer elements and producing proteins that activate NF-KB.Besides the immune responses and viral replication, NF-KB is also implicated in cellular proliferation and programmed cell death.Coincidentally, deregulation of NF-KB activity is directly associated with cellular transformation.The NF-KB homologs, Dorsal and Dif in the fruit fly Drosophila, are involved in the formation of embryonic polarity and insect immunity, respectively.Thus, the understanding of the regulation of RelINF-KB activity is of great interest to a wide variety of basic biological and medical fields.
    Kappa
    Association (psychology)
    Citations (1,742)
    Tanshinol ameliorates CCl4-induced liver fibrosis in rats through the regulation of Nrf2/HO-1 and NF-κB/IκBα signaling pathway
    DOAJ (DOAJ: Directory of Open Access Journals) (2018)
    Ran WangJianwei WangFugui SongLi SYuan Yuan
    Kappa
    Alpha (finance)
    CCL4
    Citations (1)
    Differential interactions of Rel-NF-kappa B complexes with I kappa B alpha determine pools of constitutive and inducible NF-kappa B activity.
    The EMBO Journal (1994)
    Paweł DobrzańskiRolf-Peter RyseckR Bravo
    Kappa
    Alpha (finance)
    Citations (114)
    Akt Suppresses Apoptosis by Stimulating the Transactivation Potential of the RelA/p65 Subunit of NF-kappa B
    Carolina Digital Repository (University of North Carolina at Chapel Hill) (2000)
    L. V. MadridC.-Y. WangDenis C. GuttridgeArndt SchotteliusA. S. Baldwin
    Kappa
    Citations (18)
    The I kappa B proteins: multifunctional regulators of Rel/NF-kappa B transcription factors.
    Genes & Development (1993)
    Amer A. BegA S Baldwin
    Kappa
    Transcription
    Citations (819)