[Preoperative assessment of at-risk patients in traumatology].
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In a randomized, prospective double blind trial evaluating antibiotic prophylaxis for internal fixation of proximal femur fractures, the prognostic value of preoperative risk parameters, namely triceps skinfold, upper arm circumference, dynamometry, serum albumin, transferrin, prealbumin, lymphocyte count and serum zinc was analyzed. A population at risk of postoperative infection could be defined with serum albumin value and lymphocyte count: a serum albumin of less than 40 g/l correlated with increased local complications and a lymphocyte count under 1400 microliters coincided with increase in systemic infections. No correlation between perioperative transfusion and postoperative infections was found.Keywords:
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Background: Patients who have signs of malnutrition have a higher risk of complications and an increased risk of death in comparison with patients who have adequate nutritional reserves. It is common and occurs in about 30% of surgical patients with gastrointestinal diseases and in up to 60% of those in whom hospital stay has been prolonged because of postoperative complications. The serum albumin level is the most readily available and clinically useful parameter. A serum albumin level greater than 3.5 g% suggests adequate protein stores and it confers a protective effect through several biological mechanisms. It predicts perioperative morbidity and mortality.Methods: Our study was conducted on a cohort of 100 Patients admitted in Department of General surgery Hamidia Hospital for major elective surgery between October 2016 and September 2017. Sample size taken was 100.Results: The present study shows that patients with serum albumin less than 3 g/dl has more postoperative complications and patients with serum albumin >3.5 g/dl has less postoperative complications which was statistically significant. The study concludes that as the serum albumin level increases the complication rate decreases.Conclusions: Our study shows that sr. albumin is a good indicator of postoperative complications. The patients with sr. albumin <3.0 g/dl had a higher complication rate which was statistically significant (p<0.05). Patients with sr. albumin >3.5 g/dl had less complications which was statistically significant (p<0.05). The correlation between the serum albumin and complication rate was statistically significant in the malignant diseases when considered separately.
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Objective:To evaluate the efficacy and value of PPH in treating severe hemorrhoids.Methods:32 patients with symptomatic circular hemorrhoids performed surgical therapy with PPH(US Qiang sheng Comp).Results:All operations were successful at one time without perioperative hermorrhage and severe postoperative complications.The mean duration of operation was 25 mins,that of hospitalization was 3.2 days.Conclusion:Surgical therapy with PPH is effective and simple in treatment of severe symptomatic hemorrhoids with less pain and postoperative complications and early recovery and shorter hospitalized time.
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Abstract Background Serum albumin has long been considered as an outcome marker in various critical illnesses. The aim of our study is to ascertain the role of serum albumin as a predictor of outcome in severe head injury patients. Materials and Methods This is a prospective observational study of patients with severe traumatic brain injury (TBI). Depending on the serum albumin level at admission, patients were dichotomized into two groups: one with normal serum albumin and other with hypoalbuminemia. Their outcomes at 6-month follow-up were assessed by the modified Glasgow Outcome Score. Result Eighty patients (57 males and 23 females) with severe TBI were included in the study. The mean age of the study patients was 39.6 + 13.1 years and the mean serum albumin level at admission was 3.7 + 1.2 g/dL with lowest being 2.2 mmol/L and highest being 6.1 mmol/L. Thirty-four patients (42.5%) had low serum albumin level (< 3.5 g/dL) at admission. At 6-month follow-up, 58 (72.5%) patients had a good neurological outcome and 22 (27.5%) had a poor outcome. The group with normal serum albumin levels showed a significantly better outcome compared with the hypoalbuminemia group (p = 0.01). On multiple regression analysis, low serum albumin emerged as the only predictor of the poor outcome in severe head injury patients. Conclusion Serum albumin at admission is an independent predictor of outcome in severe TBI patients. Larger prospective studies are required to confirm these findings.
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목적: 위 절제술을 받은 위암 환자에서 수술 전후의 영양상태를 손쉽게 시행할 수 있는 간단한 임상적 자료로 변화를 살펴 보고 이들과 수술 후 단기간의 합병증과의 상관관계를 밝히고자 하였다. 대상 및 방법: 2008년 1월부터 2008년 6월까지 위암으로 위 절제술을 시행 받은 환자 669명을 대상으로 이들의 의무기록을 후향적으로 고찰하였다. 환자의 영양 상태를 평가하기 위해 수술 전과 수술 5일 후, 수술 6개월 후의 총 림프구수(TLC, cells/ $mm^3$ ), 혈중 알부민(g/dl), 체중(kg), 체질량 지수(BMI, kg/ $m^2$ )를 측정하였다. 또한 이들 인자들과 단기간 합병증 발생과의 상관관계를 분석하였다. 결과: TLC와 혈중 알부민은 수술 전에 비해, 수술 5일 후에는 전반적으로 감소되었다가 수술 6개월 후에는 다시 회복하는 추세를 보였다. 6개월 후 환자의 영향 상태에 미치는 요인을 살펴보면, 진행성 위암에서 수술 6개월 후 TLC, 혈중 알부민이 더 낮은 경향을 보였다. 위전절제술 후에 6개월 후의 혈중 알부민과 BMI가 더 낮아지는 경향을 보였다. 보조적 치료를 한 군의 6개월 뒤의 TLC가 더 낮은 경향을 보였고, 체중 감소 비율도 더 컸다. 단기간 합병증 발생과의 상관관계를 갖는 영양 인자는 수술 후 5일째 혈중 알부민과 수술 전과 수술 후 5일째의 혈중 알부민 변화량이었다. 결론: TLC와 혈중 알부민은 수술 5후에는 유의하게 감소 되었다가 수술 6개월 후에는 회복 추세를 보였다. 수술 후 5일째의 혈중 알부민 저하가 합병증과 관련 있는 요소로서, 이환율에 대한 좋은 예측도를 나타내는 지표였다. 【Purpose: The aim of this study was to evaluate the preoperative and postoperative nutritional statuses of patients with gastric cancer and to investigate the nutritional factors that are correlated with perioperative complications. Materials and Methods: From January 2008 to Jun 2008, 669 patients who underwent curative gastrectomy were enrolled in a retrospective study. To evaluate the changes of their nutritional status preoperatively and postoperatively, we measured the total lymphocyte count, the serum albumin, the body weight change and the BMI. The nutritional factors correlated with short-term postoperative complications were analyzed. Results: The total lymphocyte count and serum albumin decreased from the first preoperative day to the $5^{th}$ day after operation, but they tended to increase and approach the normal range 6 months after operation. The only factor correlated with the short-term postoperative complications (defined as the ones that occurred for 30 days) was the serum albumin checked on the $5^{th}$ day after operation. Conclusion: Low serum albumin on the $5^{th}$ day after operation was correlated with postoperative short-term complications. Serum albumin can be the preoperative statistical parameter that can predict the occurrence of postoperative complications.】
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Objective To comparatively analyze the efficacy of compound amino acid injection for gynecological cancer in perioperative period. Methods 98 patients were randomly divided into the control group( treated with conventional therapy)and the experimental group( treated with conventional therapy and compound amino acid injection( 20AA) from the day of operation for 3 days),each with 49 cases. Postoperativetotal protein、albumin、prealbumin、venting times and hospital stays of the 2groups were observed. Results Preoperative total protein、albumin and prealbumin of the 2 groups had no significant difference.Total protein and albumin of the 2 groups decreased after operation. Rise of total protein、albumin and prealbumin in the experimental group was significantly higher than that of the control group 4 days after operation( P 0. 05),there had statistical difference. Venting times and hospital stays in the experimental group were shorter than those of the control group,and poor wound healing in the experimental group was less than that of the control group,there had statistical difference. Conclusion Compound amino acid injection for gynecological cancer in perioperative period is effective,and it can improve recovery.
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We assessed the perioperative pattern of serum ischemia-modified albumin and its role as a myocardial ischemia indicator for early detection of perioperative myocardial infarction in patients undergoing off-pump coronary artery bypass grafting. Venous blood samples were collected from 63 consecutive patients before the operation, immediately after the operation, and at 3, 6, 12, and 24 h postoperatively. Serum ischemia-modified albumin levels were analyzed using an albumin cobalt binding test. The patients were divided into 2 groups retrospectively, according to the occurrence of perioperative myocardial infarction. The serum ischemia-modified albumin levels were compared between groups. The levels peaked immediately after the operation, followed by a gradual regression, but remained elevated during the first 24 h in all patients. The occurrence of perioperative myocardial infarction was identified in 10 patients who had significantly higher ischemia-modified albumin levels at 3 h postoperatively and slower regression rates. Perioperative serum ischemia-modified albumin levels might be helpful in predicting perioperative myocardial infarction.
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Background: We previously reported that single measurements of albumin strongly predict survival in HIV-1-infected women independent of disease-specific markers. We now extend this to the use of serial measurements and single albumin values prior to initiation of highly active antiretroviral therapy. Design: Prospective cohort study of 1941 women enrolled at six sites in the Women's Interagency HIV Study. Results: Albumin fell 0.44 g/L/y in 1627 women who survived and at a faster rate in 397 who died (1.54 g/L/y; p < .01). In a time-dependent model adjusting for disease markers, the relative hazard (RH) was fivefold higher in patients with serum albumin <35 g/L compared with patients with serum albumin >42 g/L. The RH of serum albumin <35 g/L in women with CD4+ lymphocyte counts ≥200 cells/μL was 8.2 [95% CI: 4.2-15.8]) versus only 3.8 [95% CI: 2.4-6.1] in those with counts <200 cells/mm3. In a fixed-covariate Cox analysis of patients who started HAART during the study, albumin prior to HAART was associated with a higher RH (7.0 for albumin <35 g/L versus >42 g/L) than were other factors. Conclusion: Serum albumin is a strong independent predictor of mortality in HIV-1-infected women after adjustment for known disease markers and may be useful for clinical monitoring.
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Objective To investigate the relationship between hypoproteinemi with postsurgical gastroparesis syndrome (PGS) during the perioperative period. Methods Two hundred patients accepted abdominal operations were randomly selected. The levels of albumin during the perioperative period were compared between the PGS patients and the Non-PGS patients. The relationship of the treatment period of PGS and the average levels of albumin were analyzed. Results Of the 200 patients, 14 were found with PGS, of which the average albumin levels during the perioperative period was (26±3.1) g/L, lower than those of the remaining 186 patients [(31±6.5) g/L], P0.05. The treatment period of PGS was shorter when the average albumin level was higher, showing a negative correlation (r=-0.42, P0.05). Conclusion Hypoproteinemia is a risk factor of PGS. Raising the albumin level is a key point in the treatment of PGS.
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As a result of the common usage of albumin in total parenteral nutrition (TPN) solutions at The Ohio State University Hospitals, a review of the use of this product was performed. Albumin therapy in 18 patients was evaluated using prospective criteria. Therapy was considered appropriate if the serum albumin level was less than or equal to 3.0 g%. Using these criteria, 12 of 18 patients (67%) received albumin in the TPN solution. Of these 12 patients, 7 received albumin unnecessarily. During the 3-week review, a total of 168 vials of 50 ml, 25% albumin (2100 g) were administered to patients with serum albumin concentrations greater than 3.0/100 ml at a cost of $6,014. Over a year, this could mean over $100,00 in costs which could be eliminated. Criteria for use of albumin in malnourished patients receiving TPN are not well established. This study demonstrated that developing simple criteria for the prospective review of albumin in TPN solutions and using them to monitor albumin therapy closely, can result in very significant cost savings to patients receiving TPN.
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