Nonviral Gene Delivery Systems by the Combination of Bubble Liposomes and Ultrasound
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Keywords:
Delivery system
Keywords: Gene therapy, Gene delivery, Oligonucleotides, Targeted delivery, Controlled release, Carriers, Smart systems.
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The basic principle of the gene therapy and the design methods and the mechanism of the non virus gene delivery system were reviewed in this paper. The prospects of the gene delivery system were also summarized.
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It is extremely important to establish and develop a safe and efficient delivery system for the gene therapy. Although the virus vectors have been used for hundreds clinical trials of gene therapy, their safety remains uncertain. Recently, more nonviral delivery systems for gene transfer have been developed and used widely. This review discussed some of the novel gene delivery systems, which are being used in our laboratory including transduction peptides, in vivo DNA electrotransfer and chitosan as DNA delivery vector
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Proteins and genes of therapeutic interests in conjunction with different delivery systems are growing towards new heights. “Next generation delivery systems” may provide more efficient platform for delivery of proteins and genes. In the present review, snapshots about the benefits of proteins or gene therapy, general procedures for therapeutic protein or gene delivery system, and different next generation delivery system such as liposome, PEGylation, HESylation, and nanoparticle based delivery have been depicted with their detailed explanation.
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Biodegradable PLGA nanoparticle is a promising nonviral gene delivery systems.In the present review,several respects such as the advantages,the factors affecting cellular internalization and transfection efficiency as well as the limita-tions and measures of this gene delivery system have been summarized.
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