Experimentally Induced Pyogenic Arthritis of Rabbit Knees: Comparative Study of MR Imaging and Pathology
0
Citation
0
Reference
10
Related Paper
Abstract:
Purpose: To compare the MR imaging findings of experimentally induced pyogenic arthritis of rabbit knees with the corresponding histopathologic findings. Materials and Methods: Infection was induced in 20 rabbit knees by direct intra-articular injection of Staphylococcus aureus. The animals were divided into four groups of five rabbits each, and spin-echo sagittal T1-and T2-weighted images were obtained 3 days, 1 week, 2 weeks, and 4 weeks, respectively, after staphylococcal inoculation. MR-pathologic correlation was performed, with emphasis on intra-and extra-articular soft tissue lesion characteristics. Soft tissue lesion signal intensity (SI) was classified as low, iso, or high on the basis of that of muscle, and high SI was further subdivided into three categories. Results: At T2-weighted imaging, all soft tissue lesions showed high SI. Pathologic examination revealed the presence of inflammatory cell infiltration (n=2), abscess (n=1), granulation tissue (n=3), fibrosis (n=11), edema (n=4), congestion (n=9), and joint fluid (n=11). Except for the abscess, these lesions were irregular in shape and had variable SI (grade 1-3) and at T2WI could not, therefore, be differentiated. In nine kness, extraarticular soft-tissue lesions were demonstrated at T2WI and correlated with infectious soft tissue lesions such as inflammatory cell infiltration, abscess, granulation tissues and fibrosis; and non-infectious reactive soft tissue changes such as edema and congestion. Conclusion: In pyogenic arthritis, the MR imaging features of soft tissue lesions varied and were nonspecific, depending on the histopathologic abnormalities observed. Our results indicate that in assessing the extent of pyogenic arthritis with MR imaging, caution is required.Keywords:
Granulation tissue
Infiltration (HVAC)
Granulation tissue
Granulation
Cite
Citations (3)
Granulation tissue
Granulation
Airway obstruction
Cite
Citations (27)
Objective: To detect the content of bFGF in rat skin ulcer wound granulation tissue and to explore the mechanism of Chuangyugao promoting ulcer healing. Methods: 60 SD rats were randomly divided into Group A( Chuangyugao),group B( MEBO)and group C( normal saline group),n = 20. The full- thickness excision injury models of those rats were made,changing the dressing every 12 hours. The granulation tissue of wounds was taken out after modeling for 3,7,14,21 d,detecting the content of bFGF in wounds with ELISA assay. Results: The expression of bFGF in the granulation tissue in Chuangyugao group was much higher than that of other two groups. There was significant difference through pair wise comparison. And on the 7th day,there was no difference between Chuangyugao group and MEBO group in the expression of bFGF in the granulation tissue,however,compared with the normal saline group,it was significantly lower and there were significant differences. Conclusion: Chuangyugao through the promotion of basic fibroblast proliferation and the growth of granulation tissue can shorten the healing time and improve the rate of wound healing.
Granulation tissue
Granulation
Cite
Citations (0)
Granulation tissue
Granulation
Cite
Citations (4)
Granulation tissue
Debridement (dental)
Skin grafting
Bone tissue
Cite
Citations (0)
Objective To investigate the vacuum sealing drainage(VSD)technology for infected wounds of soft tissue defects.Methods From July 2008 to June 2009,we got 30 patients with soft tissue defects,all of whom were given VSD.After the granulation was fresh,direct suture,skin graft or split-thickness skin graft were carried out to repair the wounds.Results All the cases recovered.Infections was cured without complications.Conclusion VSD in the treatment of infected wounds of soft tissue defects can promote the growth of granulation tissue,reduce or prevent wound infection,promote wound healing,and is easy to operate and promote.
Granulation tissue
Scar tissue
Cite
Citations (0)
The granulation tissue, which are found in nonspecific inflammation, occasionally seemed like round mass. We experienced and report four cases in which the granulation tissue presented as endobronchial mass on the bronchoscopy. The masses obstructing lobar or segmental bronchial oriface were round, smooth surfaced and pinkish except whitish one case. The granulation tissue caused by acute or chronic inflammations, should be considered to differentiate endobronchial mass.
Granulation tissue
Granulation
Cite
Citations (0)
This work was undertaken to study the effects of various doses of interferon-gamma (IFN-gamma) on developing granulation tissue in rats and on granulation tissue-derived fibroblasts in culture. For in vivo studies cylindrical hollow sponge implants were used as an inductive matrix for the growth of granulation tissue. In the test groups the implants were injected daily for four days with a solution containing 160, 800, 4000, or 20000 units of IFN-gamma while the implants of the control group were treated correspondingly with the carrier solution only. Analyses of granulation tissue in the sponge cylinders, carried out 7 days after implantation, showed an IFN-gamma-related decrease in the formation of new granulation tissue. The largest, dose-dependent effect was seen in the accumulation of collagen. For in vitro studies, cultures of rat granulation tissue fibroblasts were treated with 100, 500, 1000, or 5000 units/ml of IFN-gamma. IFN-gamma decreased collagen synthesis to about 50 per cent of that in controls. IFN-gamma treatment also decreased type I procollagen mRNA levels maximally by 41 per cent from the control level. It is concluded that IFN-gamma inhibits the formation of new granulation tissue by decreasing collagen synthesis.
Granulation tissue
Granulation
Cite
Citations (35)
Many wounds to both soft and hard tissues heal via the formation of a granulation tissue bed. This bed is supportive of neoangiogenesis and releases proangiogenic, migratory, and proliferative growth factors and cytokines. In this study granulation tissue was grown on an intraperitoneal implant (4 mm diameter, 20 mm length) in a sheep. After 2 weeks, this implant was removed and transplanted into a femoral bone defect (4 mm diameter, 20 mm length). The sheep were sacrificed after 3 months, and the implant site examined using micro-CT and histology. A bone plaque formed adjacent to the implant, only in the presence of the peritoneal granulation tissue. This suggests that the formation of granulation tissue is a relatively conserved response at various locations in the body and its transplantation from one location to another can be used to induce tissue healing. This technique may prove useful as a method of improving physiological response to biomaterials.
Granulation tissue
Granulation
Histology
Bone tissue
Cite
Citations (3)
Granulation tissue
Granulation
Cite
Citations (65)