Ganciclovir in the treatment of cytomegalovirus pneumonitis in bone marrow transplant recipients.

Abstract Study Objective:To determine the efficacy of ganciclovir for the treatment of cytomegalovirus enteritis after bone marrow transplant. Design:A randomized, double-blind, placebo-controlled ...

Bone marrow transplant

Cytomegalovirus

Cytomegalovirus infections

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Strategies for management of cytomegalovirus (CMV) infection after allogeneic bone marrow transplantation: the “doubling of baseline CMV pp65 antigenemia” and the “cidofovir as rescue treatment” approaches

Blood (2001)

Elio Castagnola Maurizio Miano Giuseppe Morreale Emilo Cristina Maura Chierici

Cidofovir

Cytomegalovirus

Bone marrow transplant

Betaherpesvirinae

Cytomegalovirus infections

10.1182/blood.v98.5.1627

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Citations (1)

IMMUNE DONORS CAN PROTECT MARROW-TRANSPLANT RECIPIENTS FROM SEVERE CYTOMEGALOVIRUS INFECTIONS

The Lancet (1987)

Jean‐Jacques Grob H. G. Prentice A. V. Hoffbrand Teresa Tate J. E. Grundy

Cytomegalovirus

Bone marrow transplant

Cytomegalovirus infections

10.1016/s0140-6736(87)92800-5

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Citations (236)

[Cytomegalovirus infection in transplant recipients].

PubMed (1998)

Hisashi Gondo

Cytomegalovirus (CMV) is the most important infectious agent in transplant recipients. The critical step in the pathogenesis of CMV infection is the reactivation of latent virus, which is affected by the immunosuppressive therapy and/or alloantigenic stimulation. The clinical effects of CMV infection include CMV disease (syndrome), an immunosuppressed state, and allograft injury. Recently, the incidence of serious CMV diseases after transplant has been decreased, probably due to the advance in the method for rapid diagnosis, the ganciclovir administration, and the effective prevention of CMV diseases. Seronegative or filtered blood products, CMV immune globulin, and prophylactic or preemptive therapy with ganciclovir appear contribute to the improvement in the prophylaxis for CMV diseases after transplant. Antigenemia-guided early treatment may be promising for the effective prevention of CMV diseases after transplant.

Cytomegalovirus

Immunosuppression

Betaherpesvirinae

Pathogenesis

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Diagnosis and treatment of cytomegalovirus pneumonitis following liver transplantation

Xi'an Jiaotong Daxue xuebao (2009)

Yong Zhang

Objective To study the diagnosis and treatment of cytomegalovirus(CMV) infection after liver transplantation.Methods The clinical data of 111 patients who received liver transplantation from November 2000 to December 2007 in our hospital were analyzed retrospectively.The recipients were diagnosed as having CMV infection by the predisposing factors,clinical symptoms and detection of CMV-PP65 and CMV-IgM in peripheral blood specimens in combination with chest X-ray.The treatment of CMV infection was administration of Ganciclovir.Results Five recipients were diagnosed as having CMV infection,with the incidence of 4.5%.Two were diagnosed as having CMV pneumonitis,with the incidence of 1.8%(40% of the recipients having CMV infection).Two were both improved.Three were diagnosed as having CMV active infection.Two of them were cured and one was improved.Conclusion The detection of CMV-PP65 is necessary for early diagnosis and guiding treatment of CMV infection.Ganciclovir can exert significant therapeutic effects on CMV infection.

Cytomegalovirus

Pneumonitis

Foscarnet

Betaherpesvirinae

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CYTOMEGALOVIRUS INFECTION IN THE BONE MARROW TRANSPLANT RECIPIENT

Infectious Disease Clinics of North America (1995)

John A. Zaia Stephen J. Forman

Cytomegalovirus

Bone marrow transplant