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    Mass spectral studies of 1-(2-chloroethoxy)-2-[(2-chloroethyl)thio]ethane and related compounds using gas chromatography–mass spectrometry (GC-MS) and gas chromatography–triple quad mass spectrometry (GC-QQQ)
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    GRAPHICAL ABSTRACTMass spectral studies of 1-(2-chloroethoxy)-2-[(2-chloroethyl)thio]ethane and related compounds using gas chromatography–mass spectrometry (GC-MS) and gas chromatography–triple quad mass spectrometry (GC-QQQ)All authorsFu-Lian Hsu, Mark D. Winemiller & Su Y. Baehttps://doi.org/10.1080/10426507.2015.1119145Published online:09 May 2016
    Keywords:
    Thio-
    ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSuspended trapping procedure for alleviation of space charge effects in gas chromatography/Fourier-transform mass spectrometryJeremiah D. Hogan and David A. LaudeCite this: Anal. Chem. 1990, 62, 5, 530–535Publication Date (Print):March 1, 1990Publication History Published online1 May 2002Published inissue 1 March 1990https://pubs.acs.org/doi/10.1021/ac00204a020https://doi.org/10.1021/ac00204a020research-articleACS PublicationsRequest reuse permissionsArticle Views57Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
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    A simple and reliable liquid-liquid extraction method for the determination of Δ9-tetrahydrocannabinol (THC) in whole blood utilizing gas chromatography-mass spectrometry in electron impact mode is described. The substance is derivatized with pentafluoropropionic anhydride in pentafluropropanol. The limit of detection is 0.5 ng/mL for a 1-mL specimen, with recovery greater than 70%. The intra-assay coefficient of variation (CV) is 3.1% to 5.2%, and the interassay CV is 6.4% to 9.5%, calculated at THC concentrations of 1, 5, and 25 ng/mL. The accuracy is between 95 and 97%. The optimization of extraction and derivatization conditions is detailed.
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    There is an increasing need for the quantitation of drugs that act on the central nervous system in blood of patients suspected of poisoning. A simple method for quantitative determination of neutral and basic drugs is described. The method involves a basic extraction without derivatization. The plasma extracts are injected on a Hewlett-Packard chromatograph using two nitrogen-specific detectors. In most cases, the comparison of relative retention times on the two columns is sufficient for identification of the ingested drugs. But when the method falls, the use of a gas chromatograph/mass spectrometer equipped with a chemical ionization source is necessary.
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