Relationship between perioperative blood transfusions and postoperative infection
0
Citation
0
Reference
20
Related Paper
Abstract:
Objective To study the relationship between perioperative transfusion and postoperative infection.Methods 567 cases of perioperative transfusion from 1992 to 2007 were analysed.According to the blood components it was divided into whole blood transfusion group,frozen plasma group,and concentrated red cell group.The relation of the blood category and quantities with postoperative infection was analysed.The results were compared with non-transfusion group of 856 cases.Results The postoperative infection rate of whole blood transfusion group was 12.4%,the infection rate of frozen plasma transfusion was 7.3%,and that of red cell transfusion was 5.6%.There was significant difference among them(P0.05).Conclusion There is a close correlation between perioperative transfusion and postoperative infection.The infection rate by whole blood or plasma transfusion is high and by component transfusion is comparatively low.Keywords:
Fresh frozen plasma
Infection rate
Cite
Fresh frozen plasma
Cite
Citations (40)
Objective To explore the feasibility of no blood transfusion for patients with esophageal carcinoma during perioperation period.Methods From Jan.2000 to Jun.2006,182 cases with esophageal carcinoma underwent esophagectomy.The patients were divided into 93 cases receiving blood transfusion group and 89 cases no-transfusion group.The data were analyzed between transfusion and no-transfusion groups.Results There were no differences in the hemoglobin,the red blood cell,the blood platelet,the amount of hemorrhage during operation and the rate of postoperative infection complication between the 2 groups(P0.05).There was difference in the tumor recurring rate and 3-,5-year survival rates(P0.05) between no-transfusion and transfusion groups.Conclusion No transfusion during perioperative period is safe and feasible for the patients with esophageal carcinoma.
Esophagectomy
Cite
Citations (0)
Objective To investigate the relationship between perioperative blood transfusion and postoperative wound infection in patients with oral squamous cell carcinoma(OSCC). Methods 753 patients with OSCC in T2 stage were retrospectively analysed. Results Postoperative wound infection rates of patients with perioperative blood transfusion and patients without perioperative blood transfusion were 8.4% and 3.9%,respectively,and there was a significant statistical difference between the two groups (P0.05). Postoperative wound infection rate was increased with the amount of blood transfusion. Conclusion Postoperative wound infection rate of patients with perioperative blood transfusion is significantly higher than that of patients without perioperative blood transfusion. Perioperative blood transfusion should be applied properly.
Wound infection
Cite
Citations (0)
This study was purposed to explore whether the blood transfusion of surgical patients can increase the severity of postoperative infection by a retrospective analysis of patients with postoperative infection in Chinese PLA General Hospital. By using a software "clinical transfusion database" developed by our department, 150 infected surgical cases were retrieved and divided into deep infection group and superficial infection group according to the infected location. These two groups were compared in term of the patient's age, duration of hospitalization, red blood cell transfusion volume, none-red cell transfusion volume, transfusion frequency and average transfusion volume. The results showed that red blood cell transfusion volume or none-red cells transfusion volume of patients with superficial infection was 4.50 (0 - 59) U or 2.95 (0 - 119.6) U, and that of deep infection was 9.00 (0 - 153) U and 8.05 (0 - 136.6) U, the differences was significant (P < 0.05). Between two groups, the transfusion frequency showed the most significant difference, median in the patients with superficial infection was about 2 (1 - 31) times, less than the deep infection group about 4 (1 - 49) times (P < 0.001). There was no significant difference between two groups in the average transfusion volume. It is concluded that perioperative blood transfusion volume and frequency of surgical patients seems to display a positive correlation with the degree of postoperative infection.
Red Cell
Cite
Citations (0)
Objective To characterize and to investigate the strategies for perioperative blood transfusion in patients receiving transplantation of small intestines. Methods A retrospective analysis was conducted on ten cases of recipients of small intestinal transplantation and their clinical blood transfusion and testing data. Results The average volume of perioperative blood transfusion of RBC was 16. 90 U and that of FFP was 2,847 m L in the ten cases of recipients of small intestinal transplantation. No transfusion of platelet and cryoprecipitate was noted. Conclusion Although the transfused amount of different components varied significantly,patients receiving small intestinal transplantation were still subjected to large amounts of blood transfusion. Thus,inspection and surveillance should be implemented in preoperative,intraoperative and postoperative blood transfusions,and different kinds of blood components should be provided for transfusion in a timely fashion in order to reduce the risk of perioperative blood transfusion.
Cryoprecipitate
Cite
Citations (0)
Background: To study the changes in haemogram and coagulation profile in patients undergoing autologous and homologous blood transfusion and suitability of the technique of autologous blood transfusion in routine blood bank management.Methods: Patients who were waiting to undergo elective surgical procedures were randomly distributed in two groups, Group A: Autologous blood transfusion, with or without haemodilution: wherein pre-operative period a predicted volume of blood was collected and Group B: Homologous blood transfusion: where required blood was arranged from Blood Bank. The cardiovascular status, the haemogram and the coagulation profile were recorded at various stages.Results: Out of 240 patients registered only 43 could fulfil the basic requirements only 25 could be motivated in each group. In Group A cases were of age group 51-60 years while it was 41-50 years in Group B. Male:Female ratio was 2:1. 47 Units were retransfused to Group A patients, Group B cases received 45 blood transfusions. In Group A patients 8% cases showed mild hypotention and 1% showed mild hypersensitivity to Haemacel. In Group B, 40% cases showed transfusion reactions. Fall in Hb was lesser in Group A (2.4) on first and (1.7) on second postoperative day compared to Group B (3.3) on first and (2.7) on second postoperative day. The haematocrit levels declined more sharply after operation in Group B (7) rather than Group A (10.4).Conclusions: Advantage of avoiding transfusion reactions, major changes in blood parameters, entry of infections proves Autologous blood transfusion to be the safest, cost effective and easy form of transfusion therapy.
Autologous blood
Group B
Group A
Autotransfusion
Blood bank
Blood units
Cite
Citations (1)
Objective To investigate the effect of blood transfusion on postoperative infection in patients with cerebral injury,and to guide reasonable blood transfusion.Methods The patients who underwent operations in our hospital from 1997.1 to 2004.11 were observed.Among them,225 patients were transfused with red blood cell(RBC) concentrates suspension,202 with leucodepleted red cell concentrate(LDRC) suspension,98 were not transfused.The rate of postoperative infection of three groups and the correlation to the amount of transfusion were compared.Results The rate of postoperative infection of the group transfused with RBC concentrates suspension was 11.11%.The rate of postoperative infection of the group transfused with LDRC suspension was 3.46%,which was significantly different from that of the group transfused with RBC concentrates suspension(P0.0l),but was not significantly different from that of the group without transfusion.The rate of postoperative infection was closed correlated to the amount of transfusion in the group transfused with RBC concentrates suspension (P0.0l),while the rate of infection was not correlated to the amount of transfusion in the other group.Conclusions In patients with cerebral injury,the rate of postoperative infection was correlated to blood transfusion,blood composition and the amount of transfusion.So if the patients can resist operation,the blood should not be transfused or transfused as little as possible.If the blood must be transfused,the leukocytes should be removed from blood by filtration.
Infection rate
Cite
Citations (0)
To explore the association of perioperative homologous blood transfusion (packed red blood cell, PRBC) and postoperative complications after radical gastrectomy in patients with gastric cancer.From October 2010 to July 2013, a total of 636 patients undergoing radical gastrectomy at Department of Gastric, Duodenal & Pancreatic Surgery at Hunan Provincial Tumor Hospital were divided into 2 groups according to perioperative blood transfusion (n = 170, 26.73%) or not (n = 466, 73.27%). Their clinicopathological data, such as age, gender, co-morbidities, surgical duration, intraoperative blood loss volume and pathological stage were retrospectively analyzed by case-control study model. And the transfusion group was further divided into subgroup by transfusion volume (total PRBC<3.0, 3.0-7.5 or >7.5 U) and timing (pre-, intra- or post-operative) to examine the association of transfusion volume and timing with postoperative complications by Logistic regression.Thirty-two patients suffered from complications in the transfusion group (18.82%). And it was significantly more common than that in the control group (10.09% (47/466) , P < 0.01). Moreover, the complication rate (33.33% (12/36) ) was obviously higher in the large transfusion volume group (PRBC>7.5 U) than with those in the moderate (15.53% (16/103), P = 0.02) and low groups (12.90% (4/31) , P = 0.04). Infection was more common along with the total amount of transfused blood (6.45% (2/31), 10.68% (11/103) and 19.44% (7/36) in the low, moderate and large transfusion group respectively). Yet the differences were insignificant (P = 0.22). There was no significant difference of complication rates among the pre-, intra- and post-operative transfusion group classified by transfusion time (P = 0.39). And the postoperative infection rates were also insignificantly different (P = 0.88). Further Logistic analysis revealed that perioperative transfusion (OR = 2.71, 95% CI: 1.40-5.27, P < 0.01) was an independent risk factor for postoperative complications after radical gastrectomy.Perioperative blood transfusion is significantly associated with postoperative complications after radical gastrectomy in patients with gastric cancer. And a positive correlation exists between infection and the amount of transfused blood. But there was no association between transfusion time and complications. Thus decreasing perioperative transfusion may reduce the incidence of postoperative complications and shorten the length of hospital stays.
Cite
Citations (2)
Objective To investigate the perioperative RBC and FFP transfusion of 1 166 patients with spine surgery,in order to evaluate the effect of blood conservation and the existing problem. Method The transfusion records of 1 166 patients with spine surgery,from January 1,1996 to December 31,2005,were retrospectively analyzed. The relationship between the variation of clinical blood transfusion and the operation type were analyzed.Result From 1996 to 2005,although the overall RBC transfusion increased with the increasing numbers of surgery,the amount of transfusion decreased in single patients,with predominant decrease in the amount of intraoperative transfusion. Large amount of blood was transfused to patients with spinal tumor surgery. The use of FFP increased rapidly since 2004,with predominant increase in the amount of intraoperative transfusion.Conclusion The practice of blood conservation is effective in the control of amount of RBC transfusion during perioperative period. Further study is needed to find out the reasons for rapid increase in plasma transfusion.
Blood conservation
Cite
Citations (0)
Background The impact of perioperative blood transfusion on short- and long-term outcomes in pediatric living donor liver transplantation (PLDLT) must still be ascertained, mainly among young children. Clinical and surgical postoperative complications related to perioperative blood transfusion are well described up to three months after adult liver transplantation. Aim To determine whether transfusion is associated with early and late postoperative complications and mortality in small patients undergoing PLDLT. Methods We evaluated the effects of perioperative transfusion on postoperative complications in recipients up to 20 kg of body weight, submitted to PLDLT. A total of 240 patients were retrospectively allocated into two groups according to postoperative complications: Minor complications (n = 109) and major complications (n = 131). Multiple logistic regression analysis identified the volume of perioperative packed red blood cells (RBC) transfusion as the only independent risk factor for major postoperative complications. The receiver operating characteristic curve was drawn to identify the optimal volume of the perioperative RBC transfusion related to the presence of major postoperative complications, defining a cutoff point of 27.5 mL/kg. Subsequently, patients were reallocated to a low-volume transfusion group (LTr; n = 103, RBC ≤ 27.5 mL/kg) and a high-volume transfusion group (HTr; n = 137, RBC > 27.5 mL/kg) so that the outcome could be analyzed. Results High-volume transfusion was associated with an increased number of major complications and mortality during hospitalization up to a 10-year follow-up period. During a short-term period, the HTr showed an increase in major infectious, cardiovascular, respiratory, and bleeding complications, with a decrease in rejection complications compared to the LTr. Over a long-term period, the HTr showed an increase in major infectious, cardiovascular, respiratory, and minor neoplastic complications, with a decrease in rejection complications. Additionally, Cox hazard regression found that high-volume RBC transfusion increased the mortality risk by 3.031-fold compared to low-volume transfusion. The Kaplan-Meier survival curves of the studied groups were compared using log-rank tests and the analysis showed significantly decreased graft survival, but with no impact in patient survival related to major complications. On the other hand, there was a significant decrease in both graft and patient survival, with high-volume RBC transfusion. Conclusion Transfusion of RBC volume higher than 27.5 mL/kg during the perioperative period is associated with a significant increase in short- and long-term postoperative morbidity and mortality after PLDLT.
Cite
Citations (12)