Application of procalcitonin and CRP as prognostic markers in surgery infections
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Objective To evaluate the value of procalcitonin and CRP as prognostic markers in surgery infections.Methods 72 patients who were treated in our hospital's surgery from 2007 to 2008.Those patents were divided into 3 groups:non-infection,intensive infection and partially infection respectively.Serum procalcitonin and CRP levels were measured in the first 3 days or before using antibiotics.Results procalcitonin and CRP levels were significantly higher than the other two groups(P 0.05),especially the procalcitonin level.Taking procalcitonin≥2 μg/L as the diagnostic standards for intensive infection,its sensitivity and specifity are higher than CRP.Conclusion Compared to CRP,Procalcitonin is a marker for the diagnosis of bacterial infections in surgery,especially for the early diagnosis.Keywords:
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Objective:To investigate the value of combined detection of serum procalcitonin(PCT)and C-reactive protein(CRP)on the diagnosis and condition determine of patients with severe infection in ICU.Methods:60 patients with severe infection in ICU were selected as the observation group, and 60 cases of non-infected in ICU were selected as a control group,serum PCT and CRP levels of groups were detected.Results:The positive rate of PCT in the observation group was 96.7%,CRP was 1000%.The levers of PCT and CRP were significantly higher than those in the control group,the differences were statistically significant(P0.05).Conclusion:PCT specificity than CRP,hence the joint monitoring of serum PCT and CRP levels in the ICU with severe infections as an important indicator of serious infections.
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Objective:To explore the diagnostic value of serum procalcitonin and CRP in neonates with bacteriotoxemia before and after treatment.Methods:We collected serum from 60 neonates with bacteriotoxemia and 60 neonates without infection.Serum procalcitonin was determined by immunochromatography,CRP was measured with trubidimetric assay.Results:The levels of PCT and CRP in neonates with bacteriotoxemia were higher significantly than those in neonate without bacteriotoxemia(P0.01).After appropriate treatment by antibiotics,PCT and CRP decreased obviously compared with those in acute period(P0.01).in the meantime,we found the sensibility and specificity of PCT were 88.2% and 100% respectively,and the sensibility and specificity of CRP were 89.5% and 70.8% respectively.Conclusion:Serum procalcitonin and CRP could be used as a rapid diagnostic marker for neonates with bacteriotoxemia,and it can also evaluate infection for patients.
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Abstract Background Biological markers such as procalcitonin, may be helpful for the diagnosis of HAP. Procalcitonin has greater diagnostic accuracy than most commonly used clinical parameters and other biomarkers of infection, such as C-reactive protein and ESR. The aim of the study was to assess the etiological and prognostic values of procalcitonin in adult patients with hospital acquired pneumonia (HAP). Methods 15 Patients with a strong suspicion of hospital acquired pneumonia. The diagnosis of HAP depends on the clinical criteria of pulmonary infection and presence of radiological findings. Complete blood picture, sputum culture and sensitivity, ESR, CRP and PCT were obtained at admission and repeated after 2 weeks. PCT was determined with Elecsys BRAHMS PCT in serum of studied patients. Results Serum PCT above 0.5 μg/L was considered highly positive for diagnosis of HAP. It was significantly higher at admission (2.72 ± 1.72 μg/L) than after two weeks (1.0 ± 1.91 μg/L). There was a statistical significant decrease in serum levels of procalcitonin (P = 0.002) in response to antibiotic therapy. Also the PCT was significantly higher in patients with bad outcome (2.11–6.0 μg/L) than patients with good outcome (1.76 ± 0.69 μg/L). Procalcitonin was significantly higher among patients with pseudomonas (5.53 ± 0.50 μg/L) and acinetobacter (2.67 ± 0.49 μg/L) and lesser among patients with Escherichia coli (1.38 ± 0.06 μg/L) and MRSA (1.09 ± 0.13 μg/L). Conclusion Procalcitonin was a good etiological and prognostic marker in hospital acquired pneumonia. PCT is the most specific biomarker and has a number of advantages over previous markers.
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Etiology
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Objective To analyze the procalcitonin(PCT) and C reactive protein(CRP)in the combined detection of diseases in clinical infection,proves that the combined detection of PCT and CRP has important clinical value in diagnosis of infectious diseases.Methods 40 cases of the virus in our hospital from 2012 January to 2013 January were infectious disease,80 cases of bacterial infection disease patients and 40 healthy subjects were used in immunofluorescence analysis and immunenephelometry procalcitonin and C reactive protein,and then the test results were analyzed.Results Severe bacterial infection group(Zu),the general bacterial infection group(Group II) procalcitonin levels were significantly higher than that ofviral infection group(Group III) and control group(Zu),the difference was statistically significant(P0.05);the positive correlation between bacterial infection group PCTand CRP,and group PCT with no relationship between CRP virus infection.Conclusion The procalcitonin and C reactive protein can be used for clinical diagnosis of infectious diseases,and procalcitonin compared with C reactive protein more in bacterial infection in clinical infection,combined detection of PCT and CRP diseasebetter effect,has great diagnostic value.
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Clinical Diagnosis
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Procalcitonin
Clinical Significance
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Background Given the high rates of mortality and morbidity in neonatal sepsis, rapid, easy-to-use, and inexpensive biomarkers with high sensitivity and specificity are needed to diagnose neonatal sepsis. Procalcitonin is often used as a predictor in identifying neonatal sepsis, but C-reactive protein (CRP) and micro-erythrocte sedimentation rate (m-ESR) may also be valid biomarkers of neonatal sepsis.Objective To compare the accuracy of procalcitonin to the combination of CRP and m-ESR, as well as to find cut-off points for the three tests, in diagnosing bacterial neonatal sepsis.Methods Subjects were neonates hospitalized from July to October 2016 in Mohammad Hoesin Hospital, Palembang with sepsis at clinical presentation and healthy neonates with sepsis risk factors. All subjects underwent complete blood counts, CRP, m-ESR, blood cultures, and procalcitonin examinations.Results Ninety-four infants were included, of whom 26 had proven sepsis. The combined values of m-ESR and CRP had 85% sensitivity, 59% specificity, and 66% accuracy. A procalcitonin (PCT) cut-off point of 9.7ng/mL showed 100% sensitivity, 96% specificity, and 97% accuracy level, which were significantly higher than the combined values of m-ESR and CRP.Conclusion The combined values of m-ESR (13 mm/hour) - CRP (17 mg/dL) and procalcitonin alone (2ng/mL) are both valid for the diagnosis of bacterial neonatal sepsis, but the accuracy of procalcitonin at 9.7ng/mL is significantly greater.
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Erythrocyte sedimentation rate
Neonatal Sepsis
Blood Culture
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Objective To evaluate the clinical value of procalcitonin as a predictor of severity in patients with community-acquired pneumonia( CAP). Methods 80 patients with CAP were divided into two groups( ≥65years,n = 50; 65 years,n = 30). Their procalcitonin,C-reactive protein( CRP),white blood cell,confusion,uremia,respiratory rate,blood pressure,CURB-65 and pneumonia severity of index( PSI) were recorded. Results The level of procalcitonin was positively correlated with CURB-65 and PSI,which was especially stronger in the elderly group( r = 0. 408). The correlation between the levels of CRP or WBC and CAP severity was low. Conclusion The level of procalcitonin is more useful than the levels of CRP or WBC to predict the severity of CAP.
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White blood cell
Pneumonia severity index
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Objective To investigate the value of procalcitonin(PCT) and C-reactive protein(CRP) in early diagnosis of neonatal sepsis.Methods We separated 179 newborn infants into two groups,which were septic group(124 cases)and control group(55 cases),serum PCT and CRP levels were measured in two groups and comparisons were done between them.Results The levels of serum PCT and CRP in septic group were significantly higher than that in control group,it were significantly higher in acute than that in restoration stage(P0.01).Conclusion Serum PCT and CRP could be used as rapid diagnostic markers for neonatal sepsis.
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Neonatal Sepsis
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Objective: To investigate the serum procalcitonin(PCT) and C-reactive protein(CRP) in the diagnosis of infectious diseases.Method: A retrospective analysis was designed to explore the relationship of procalcitonin and C-reactive protein levels and Infectious disease.All the cases were confirmed by clinical trials of pathogenic examination in our hospital clinical laboratory.Result: The level of procalcitonin and C-reactive protein in serum is related to the severity of the infection disease.The concentration of procalcitonin between bacterial infection group and normal control group was different statistically significant(P 0.05);the concentration of procalcitonin in the bacterial infection group compared to the original with the viral infection group,the difference was statistically significant(P 0.05);the concentration of procalcitonin in the infection group and normal control group was no significant difference(P 0.05).C-reactive protein compared among the three groups,were statistically significant(P 0.05).Conclusion: Using the serum procalcitonin and C-reactive protein in the detection of clinical infection diagnosis can improve the accuracy of the diagnosis in the infectious diseases.
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Clinical Diagnosis
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