Palliative Total Scalp Irradiation Technique in Patient with Widespread Scalp Involvement of Angiosarcoma: Case Report
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ÖZETTüm skalp ışınlaması (TSI) yaygın skalp tutulumu yapabilen tümöre sahip hastalarda sıklıkla palyatif amaçlı kullanılmaktadır.Tüm skalpte tedavi edici dozun homojen bir şekilde dağılımı ile birlikte beyin ve diğer risk altındaki organların korunabilmesi TSI'ın hem planlanma hem de uygulamasındaki önemli teknik zorluklardır.Yıllar içerisinde tedavi modalitelerindeki teknolojik gelişmeler doğrultusunda TSI'nda farklı teknikler tanımlanmıştır.Fakat üst teknolojilere sahip olmayan tedavi merkezleri için çok fazla farklı seçenek bulunmamaktadır.Bu makalemizde yaygın skalp tutulumu olan 88 yaşında anjiyosarkom tanılı erkek hastamıza palyatif amaçlı (45 Gy/15 frÖZETTüm skalp ışınlaması (TSI) yaygın skalp tutulumu yapabilen tümöre sahip hastalarda sıklıkla palyatif amaçlı kullanılmaktadır.Tüm skalpte tedavi edici dozun homojen bir şekilde dağılımı ile birlikte beyin ve diğer risk altındaki organların korunabilmesi TSI'ın hem planlanma hem de uygulamasındaki önemli teknik zorluklardır.Yıllar içerisinde tedavi modalitelerindeki teknolojik gelişmeler doğrultusunda TSI'nda farklı teknikler tanımlanmıştır.Fakat üst teknolojilere sahip olmayan tedavi merkezleri için çok fazla farklı seçenek bulunmamaktadır.Bu makalemizde yaygın skalp tutulumu olan 88 yaşında anjiyosarkom tanılı erkek hastamıza palyatif amaçlı (45 Gy/15 fr
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Genentech is partnering with the German cancer company Affimed to develop immunotherapies for multiple kinds of solid and blood cancers. Affimed is developing therapies that engage natural killer cells of the innate immune system to help direct them to attack cancer cells. Genentech will pay Affimed $96 million up front and up to $5 billion more in potential payments.
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Conclusion:Radical radiotherapy is feasible and effective for elderly or unfit patients.Three-year locoregional control after radical radiotherapy using a boost technique was 72%, with low rates for late urinary and intestinal toxicity.Early and late toxicity rates were reduced by using IMRT.
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Six cases of angiosarcoma of the scalp are reported. The tumors are histologically indistinguishable from the "postmastectomy" lymphangiosarcomas reported by Stewart and Treves. With a single exception they were extensive, aggressive neoplasms that widely infiltrated the dermis and soft tissues. Although these tumors are rare malignancies of the skin, there appears to be a peculiar, unexplained predilection for the scalp.
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Angiosarcoma of the scalp is a relatively rare skin malignant disorder. We experienced a case of angiosarcoma. A 74-year-old woman admitted our hospital with a tumor which had appeared 1 month before on her right frontal scalp. Three months ago she got injures for two times on the scalp where exact same place the tumor appeared. She was diagnosed as angiosarcoma by typical clinical and histopathological features. She was intensively treated with rIL-2 and surgical operation. Intra-arterial infusion of rIL-2 was carried out before the operation. After the operation she was treated with intra-venous infusion of rIL-2. At the time of beginning the treatment, diameter of the tumor was 5cm and decreased to 3cm just before the operation. We estimated the IL-2 therapy benefitable for decreasing the tumor-size. No recurence is observed until now. [Skin Cancer (Japan) 2000; 15 : 276-279]
Hemangiosarcoma
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Six cases of angiosarcoma of the scalp are reported. The tumors are histologically indistinguishable from the "postmastectomy" lymphangiosarcomas reported by Stewart and Treves. With a single exception they were extensive, aggressive neoplasms that widely infiltrated the dermis and soft tissues. Although these tumors are rare malignancies of the skin, there appears to be a peculiar, unexplained predilection for the scalp.
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Abstract Background Primary cutaneous angiosarcoma (CA) is a rare but aggressive tumor with a high rate of local recurrence. This study was designed to analyze the clinicopathological features of primary CA and identify factors of cutaneous manifestations associated with the prognosis of angiosarcoma. Methods Medical records of 55 patients with primary CA were retrospectively analyzed to investigate clinical features, survivals, and prognostic factors. Anatomical location of tumor was classified to the scalp, face, and neck, and sites outside the head and neck. Results Primary CA presented cutaneous nodules (31/55, 47.2%), patches (13/55, 23.6%), and indurated plaques (11/55, 20.0%). Nodular lesion was significantly more common in CA on the scalp compared to CA on sites outside the scalp. Histologically, tumors presenting as nodular lesions on the scalp was predominantly composed of solid sheets of large pleomorphic cells, whereas non‐nodular lesions composed of tumor cells between collagen bundles forming irregular vascular spaces. Cutaneous angiosarcoma on the scalp showed a worse prognosis compared to CA on sites outside the scalp. Patients presenting clinical morphology with nodules and multiple skin lesions showed significantly reduced overall survival (OS). Conclusion In primary CA, location on the scalp, morphology with nodules, and multiplicity of skin lesions significantly affected survival outcomes.
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Cutaneous angiosarcoma (AS) of the face and scalp of the elderly is an uncommon neoplasm of mesenchymal origin characterized by particularly aggressive behavior. It is frequently discovered after local trauma and clinically it may appear as a benign, inflammatory lesion. In most patients, a definitive diagnosis is delayed, leading to a poor prognosis. Only early diagnosis can modify this course, as treatment in the initial stages of [...]
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The nationally-recognized Susquehanna
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A 80-year-old woman presented with a spontaneously bleeding wound on her scalp. The diagnosis of angiosarcoma was made based on histopathological examination of the second biopsy 1 month later. At that time, a large hematoma was present on the scalp and forehead with two bleeding erosions and numerous small blue-black nodules as well as a right cervical lymphadenopathy. The patient was treated by wide-field electron-beam radiotherapy, which showed no effect. The particularly aggressive evolution of this angiosarcoma led to death within less than 2 months.
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