Maximal Diameter of Lymph Node Was Not a Prognostic Factor for Stage II Nasopharyngeal Carcinoma Treated by Radiation Therapy Alone
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Primary tumor
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To investigate the prognostic factors in surgically managed patients with stage II non-small cell lung cancer.A retrospective analysis of clinical data of surgically managed 93 patients with stage II non-small cell lung cancer in our hospital between May 2005 and November 2009 was conducted, and prognostic factors that may impact the postoperative 5-year survival rate were statistically analyzed.Univariable survival analysis showed that new TNM staging, total number of dissected lymph nodes, number of dissected N1 and N2 lymph nodes and N1 lymph groups, metastasis rate of N1 lymph nodes, and 10th group of lymph nodes metastatic or not, were related to the postoperative 5-year survival rate in the patients. Multivariable survival analysis showed that the metastasis rate of N1 lymph nodes and 10th group of lymph nodes metastatic or not were independent prognostic factors for the postoperative 5-year survival rate in the patients.When patients with stage II non-small cell lung cancer are treated with surgery, the total number of dissected lymph nodes greater than 6, the number of dissected N1 lymph nodes over 5, N2 over 2, and the number of dissected N1 groups over 3, may improve their postoperative 5-year survival rate. The metastasis rate of N1 lymph nodes over 50%, and the metastasis of the 10th group of lymph nodes imply poor prognosis of the patients.
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Objective To analyze affect of the inducing chemotherapy plus the concurrent comprehensive application of radiotherapy and chemotherapy on survival rate of nasopharyngeal carcinoma. Methods One hundred and forty-three patients with stage Ⅲ nasopharyngeal carcinoma and 94 patients with ⅣA nasopharyngeal carcinoma treated in our hospital from January 1998 to December 1999 were selected and divided into the comprehensive radiotherapy and chemotherapy group with 164 patients and the simple radical radiotherapy group with 73 patients. The short-term survival rate, namely the complete remission rate, local tumor control rate and survival rate, of the two groups were compared. Results In comprehensive radiotherapy and chemotherapy group the complete remission rate, local tumor control rate and survival rate were significantly higher than the simple radical radiotherapy group (P 0.05). Conclusion The inducing chemotherapy plus the concurrent comprehensive application of radiotherapy and chemotherapy can improve the remission rate, local tumor control rate and survival rate for patients with locally advanced nasopharyngeal carcinoma, is a reasonable and effective treatment method for the locally advanced nasopharyngeal carcinoma, and can be widely applied in clinical treatment.
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<div>Abstract<p>In this study, we aimed to use the combined detection of multiple antibodies against Epstein–Barr virus (EBV) antigens to develop a model for screening and diagnosis of nasopharyngeal carcinoma (NPC). Samples of 300 nasopharyngeal carcinoma patients and 494 controls, including 294 healthy subjects (HC), 99 non-nasopharyngeal carcinoma cancer patients (NNPC), and 101 patients with benign nasopharyngeal lesions (BNL), were incubated with the EUROLINE Anti-EBV Profile 2, and band intensities were used to establish a risk prediction model. The nasopharyngeal carcinoma risk probability analysis based on the panel of VCAgp125 IgA, EBNA-1 IgA, EA-D IgA, EBNA-1 IgG, EAD IgG, and VCAp19 IgG displayed the best performance. When using 26.1% as the cutoff point in ROC analysis, the AUC value and sensitivity/specificity were 0.951 and 90.7%/86.2%, respectively, in nasopharyngeal carcinoma and all controls. In nasopharyngeal carcinoma and controls without the non-nasopharyngeal carcinoma and BNL groups, the AUC value and sensitivity/specificity were 0.957 and 90.7%/88.1%, respectively. The diagnostic specificity and sensitivity of the EUROLINE Anti-EBV Profile 2 assay for both nasopharyngeal carcinoma and early-stage nasopharyngeal carcinoma were higher than that of mono-antibody detection by immune-enzymatic assay and real-time PCR (EBV DNA). In the VCA-IgA–negative group, 82.6% of nasopharyngeal carcinoma patients showed high probability for nasopharyngeal carcinoma, and the negative predictive value was 97.1%. In the VCA-IgA–positive group, 73.3% of healthy subjects showed low probability. The positive predictive value reached 98.2% in this group. The nasopharyngeal carcinoma risk probability value determined by the EUROLINE Anti-EBV Profile 2 might be a suitable tool for nasopharyngeal carcinoma screening. <i>Cancer Prev Res; 10(9); 542–50. ©2017 AACR</i>.</p></div>
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The efficiency of combined positron emission and computer tomography in the diagnosis of primary metastatic lymph nodes of the neck was analyzed. It was established that in 34% fully examined patients was identified the primary tumor. In 32% of patients was detected distant metastases to other organs and lymph nodes. In more than 60% of patients using this method provided additional information and influence on the tactics of their treatment. Thus we believe that PET-CT should be included in diagnostic algorithm of this category of patients.
Primary tumor
Cervical lymph nodes
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<div>Abstract<p>In this study, we aimed to use the combined detection of multiple antibodies against Epstein–Barr virus (EBV) antigens to develop a model for screening and diagnosis of nasopharyngeal carcinoma (NPC). Samples of 300 nasopharyngeal carcinoma patients and 494 controls, including 294 healthy subjects (HC), 99 non-nasopharyngeal carcinoma cancer patients (NNPC), and 101 patients with benign nasopharyngeal lesions (BNL), were incubated with the EUROLINE Anti-EBV Profile 2, and band intensities were used to establish a risk prediction model. The nasopharyngeal carcinoma risk probability analysis based on the panel of VCAgp125 IgA, EBNA-1 IgA, EA-D IgA, EBNA-1 IgG, EAD IgG, and VCAp19 IgG displayed the best performance. When using 26.1% as the cutoff point in ROC analysis, the AUC value and sensitivity/specificity were 0.951 and 90.7%/86.2%, respectively, in nasopharyngeal carcinoma and all controls. In nasopharyngeal carcinoma and controls without the non-nasopharyngeal carcinoma and BNL groups, the AUC value and sensitivity/specificity were 0.957 and 90.7%/88.1%, respectively. The diagnostic specificity and sensitivity of the EUROLINE Anti-EBV Profile 2 assay for both nasopharyngeal carcinoma and early-stage nasopharyngeal carcinoma were higher than that of mono-antibody detection by immune-enzymatic assay and real-time PCR (EBV DNA). In the VCA-IgA–negative group, 82.6% of nasopharyngeal carcinoma patients showed high probability for nasopharyngeal carcinoma, and the negative predictive value was 97.1%. In the VCA-IgA–positive group, 73.3% of healthy subjects showed low probability. The positive predictive value reached 98.2% in this group. The nasopharyngeal carcinoma risk probability value determined by the EUROLINE Anti-EBV Profile 2 might be a suitable tool for nasopharyngeal carcinoma screening. <i>Cancer Prev Res; 10(9); 542–50. ©2017 AACR</i>.</p></div>
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Objective To evaluate the therapeutic effects and prognostic factors of transanal local excision of rectal carcinoma. Methods We retrospectively analyzed 116 cases who underwent transanal lical excision for rectal carcinoma from 1995 to 2008 with the mented of Cox Regression analysis.Result The survival time of all the patients were from 14 to 160.5 months.median time was 58.5 months.Five-year overall survival rate was 72%.ten-year overall survival rate was 53%.There were 16 cases of local recurrence with a rate of 13.8%.In the univariate survival analysis:histopathology,depth of tumor invasion,radiotherapy,recurrence and metastases were the predictors of survival.In the Cox regression analysis:depth of invasion,recurrence and metastases were the independent prognostic taetors for surwval.For T_1 stage,its overall local recurrence rate was 6.3%,five-year overall survival rate was 93%,ten-year overall survival rate Was 85%:For T_2 stage,its overall local recurrence rate was 14.8%,five-year overallsurvival rate Was 63%.ten.year overall survival rate was 45%.For T_1 stage,there Was no local recurrence with radiotherapy:For T_2 stage,local recurrence rate Was 14.6%.From the surivival curve,there Was no difference betwecn the patient accepted radiotherapy or not(T_1:P=0.260,T_2,P=0.262).But for local recurrence,the differences Was significant(P=0.002). Conclusion The result of transanal local excision of rectal carcinoma is satisfactory with T_1 stage,but it is not suitable for T_2 stage tumors.
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Rectal neoplasms; Surgical procedures,operative; Radiotherapy; Prognosis
Histopathology
Rectal carcinoma
T-stage
Univariate analysis
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The aim of this study, was to investigate the relationship between 18F‑fluorodeoxyglucose (18F‑FDG) uptake in primary tumors and the clinicopathological characteristics of esophageal squamous cell carcinoma (ESCC) patients. Patients with histopathologically diagnosed ESCC who had received a pre‑therapeutic 18F‑FDG positron emission tomography‑computed tomography (PET‑CT) scan were enrolled in the study. The maximum standardized uptake value (SUVmax) and the length of the primary tumor were measured by PET‑CT. The clinical tumor‑node‑metastasis (TNM) stage was determined mainly by PET‑CT images according to the American Joint Committee on Cancer (AJCC) staging system, 2002. A significant difference was observed in SUVmax between the length and T stage of the primary tumor (P=0.000 and P=0.017, respectively), but not in the grade of tumor differentiation (P=0.383), clinical stage (P=0.583), N staging (P=0.387), M staging (P=0.886), patient age (P=0.752) or gender (P=0.233). There was a significant positive correlation between the SUVmax and the length of the tumor (r=0.456, P=0.000) and the depth of invasion of the primary tumor (r=0.257, P=0.006). After controlling for length, no statistically significant correlation was found between T stage and SUVmax (r=0.074, P=0.537). In conclusion, these findings suggest that tumor length influences FDG uptake in ESCC tumors, and that the T stage of the primary tumor is not significantly correlated with the SUVmax after controlling for length. However, we did not find a significant correlation between the SUVmax and primary tumor differentiation and clinical stage. These data provide important information for the management of ESCC.
Standardized uptake value
Primary tumor
T-stage
Fluorodeoxyglucose
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Objective To explore correlation between Epstern-Barr virus and angiogenesis of patients with nasopharyngeal carcinoma.Methods Epstern-Barr virus DNA of 54 patients with nasopharyngeal carcinoma was measured by PCR and their serum vascular endothelial growth factor(serum VEGF) level was also detected by ELISA,and these data was compared and analyzed with serum vascular endothelial growth factor level of 40 health control.Results Serum vascular endothelial growth factor level of 54 patients with nasopharyngeal carcinoma(143.86±19.49) pg/mL was very higher than that of 40 health control(51.23±12.66) pg/mL,(P0.01);Serum vascular endothelial growth factor level of 24 EBV positive patients with nasopharyngeal carcinoma(195.44±19.69) pg/mL was remarkable higher than that of 30 EBV negative patients with nasopharyngeal carcinoma(154.58±15.23 pg/mL),(P0.01).Conclusion Serum vascular endothelial growth factor level changed in patients with nasopharyngeal carcinoma may be as a new tumor mark for determining disease advancing about nasopharyngeal carcinoma.
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Nasopharyngeal carcinoma (nasopharyngeal carcinoma) is one of the most common tumor diseases at present. Due to its special clinicopathological characteristics and strong sensitivity to radiotherapy, it is easy to relapse and even cause distant metastasis after treatment. At present, the screening and diagnosis of nasopharyngeal carcinoma mainly relies on image detection. This detection method shows low sensitivity in the screening and clinical staging of nasopharyngeal carcinoma, so the effect is not ideal. The purpose of this paper is to study the significance of epstein-barr virus DNA concentration detection in the screening of nasopharyngeal carcinoma and clinical staging diagnosis, so as to provide theoretical support for the diagnosis of nasopharyngeal carcinoma. This article first to EB virus, and discusses the specific concept of nasopharyngeal carcinoma (NPC), then simply discusses the EB virus and development of the relationship between nasopharyngeal carcinoma, and the studies of the relationship between the simple illustration, finally analyzed with related experiments EB virus DNA testing in the value of screening and clinical staging diagnosis of nasopharyngeal carcinoma (NPC). The experimental results showed that the basic age composition of the three groups of people in the study was relatively consistent. The average age was 49.6 years old, and the majority of them were males, accounting for 85.4% of the total number of patients. The positive values of vca-iga antibody and epstein-barr virus DNA in different groups were the highest in the nasopharyngeal carcinoma group, with concentrations of 91.6% and 52.1%, respectively. Compared with the traditional detection methods, the detection of EB virus DNA concentration has been significantly improved in the diagnosis speed and effect of nasopharyngeal carcinoma, with the diagnosis speed increased by about 17% and the diagnosis efficiency increased by about 30%.
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OBJECTIVE:To explore the clinical significance of quantitative detection of Epstein-Barr virus infectious status in nasopharyngeal carcinoma tissues.METHODS:The carcinoma tissues and adjacent tissues from 30 patients with poorly differentiated nasopharyngeal squamous cell carcinoma were prepared simultaneously,and nasopharyngeal tissues from 15 healthy subjects were used as the control.The EBV DNA copies in the samples were tested by using rea1-time quantitative polymerase chain reaction(PCR).RESULTS:The infectiou rates of EBV were 73.3%(11/15)in nasopharyngeal tissues of healthy subjects(mean EBV DNA copies of 6.5×102 μg-1 DNA),100%(30/30)in carcinoma tissues and 76.7%(23/30)in adjacent tissues of nasopharyngeal carcinoma patients(mean EBV DNA copies of 6.7×105 μg-1 DNA and 1.3×105 μg-1 DNA)respectively.There was no significant diference in the infectious rates and levels of EBV between the adjacent carcinoma tissues of nasopharyngeal carcinoma patients and nasopharyngeal tissues of healthy subjects(P0.05).The infectious level of EBV was significantly higher in carcinoma tissues than in adjacent tissues,and significantly higher in adjacent tissues than in normal nasopharyngeal tissues of nasopharyngeal carcinoma patients(P0.01).CONCLUSIONS:EBV latent infection is a common phenomenon in nasopharyngeal tissues of both nasopharyngeal carcinoma patients and healthy persons.The enhancement of EBV infection plays an important role during carcinogenesis of nasopharyngeal carcinoma patients,which sheds further light on the occurrence of EBV with nasopharyngeal carcinoma.
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