Vaccine against hepatitis B — 18 months prevention in a high risk setting
21
Citation
19
Reference
10
Related Paper
Keywords:
Medical microbiology
Hepatitis A vaccine
Hepatitis B
Hepatitis B vaccine
Objective To study the immunogenicity and safety of concurrent hepatitis A and hepatitis B vaccination in recruits.Methods Two-hundred recruits were randomly divided into A,B,C,D four groups:group A received hepatitis A vaccines,group B received hepatitis B vaccines,group C received hepatitis A vaccines in the right arms and received hepatitis B in the left arms,group D received combined hepatitis A and B vaccine.The immunogenicity and safety were assessed later7months after the first dose.Result In group C,the seropositive rate for antibody to hepatitis A and B were100%and91.84%respectively.In group D,the seropositive rate for antibody to hepatitis A and B were100%and92.50%respectively.There was no significant difference between being vaccinated through the combined way and through the solely way.Conclusion It is effective and safe for recruits to receive concurrent hepatitis A and B vaccines.
Hepatitis A vaccine
Hepatitis B vaccine
Hepatitis B
Hepatitis C
Cite
Citations (0)
Objective To study the immune efficacy and safety of 10μg and 5μg hepatitis B vaccine in newborns and to provide the scientific basis for the adjustment of neonatal hepatitis B vaccine immunization programs. Methods The HBV antibody levels of people who inoculated various doses of hepatitis B vaccine in different time were observed when they were born with case-control study method. Serum antibody levels were detected by chemiluminescence immunoassay. Results 1 month, 6 months and 12 months after full course of inoculation of hepatitis B vaccine, non-response rate in 10μg hepatitis B vaccine was higher than that of 5μg hepatitis B vaccination group. The titer of HBsAb in 10μg hepatitis B vaccine group was higher than that of 5μg hepatitis B vaccination group. 12 months after inoculation, the titer of HBsAb in two groups were both reduced, and the positive rate of HBsAb in10μg hepatitis B vaccine group was higher than that of 5μg hepatitis B vaccination group. Conclusion The efficacy of 10μg hepatitis B vaccine group is better than that of 5μg hepatitis B vaccine group.
Hepatitis B vaccine
Hepatitis B
Hepatitis A vaccine
Group B
Cite
Citations (0)
With a view to observe the immunogenicity of the Healive ○R inactivated hepatitis A vaccine, 70 HAV-seronegative children in the mountain area villages aged 1-10 years who had received the live attenuated hepatitis A vaccine within one year were selected. All of them administered a booster dose of healive ○R inactivated hepatitis A vaccine. Hepatitis A virus antibody was measured by ELISA assay after one month.The results showed that the anti-HAV positive seroconversion rate was 100% in all children,the GMT was 3,013mIU/ml.The longer the interval between live attenuated hepatitis A vaccine adminustration and the Healive ○R boosting was,the higher the level of anti-HAV and GMT were,it was in accordance with the immune effect of 2-dose of different schedules of Healive ○R inactivated vaccine,but rather lower in anti-HAV and GMT levels.So,Healive ○R inactivated hepatitis A vaccine can be used as booster vaccination to children who had reciered live attenuated hepatitis A vaccine before to induce high anti-HAV and GMT levels.
Hepatitis A vaccine
Seroconversion
Inactivated vaccine
Booster dose
Attenuated vaccine
Cite
Citations (0)
[Objective]To assess the effectiveness and safety of the booster immunization with inactivated hepatitis A vaccine/hepatitis A and hepatitis B combined vaccine,in order to provide the basis for hepatitis A vaccine and hepatitis B vaccine immunization strategy.[Methods]A total of 210 children aged 24-38 months old were divided into two groups.One group were vaccinated with inactivated hepatitis A vaccine and another group waere vaccinated with hepatitis A and hepatitis B combined vaccine.Serum samples were collected after one month and detected anti-HAs with ELISA,anti-HBs with CMIA in order to evaluate GMC and antibody positive rate before and after immunization.Body temperature and clinical symptom were observed for 3 three days in order to evaluate its safety.[Results]Hepatitis A antibody positive rate rose from 95.20% to 100.00% and GMC increased 55.74 times in Hepatitis A vaccine group.Hepatitis A antibody positive rate rose from 88.80% to 98.90% and GMC increased 58.35 times in another group.Hepatitis B antibody positive rate rose from 72.90% to 97.80% and GMC increased from 22.20 mIU/ ml to 1 226.10 mIU/ml which increased by 54.50 times.The effectiveness of booster immunization was very obvious.12 cases were observed with adverse reactions and all were fever.The incidence was 5.74%.Severe adverse reaction was not found.[Conclusion]Inactivated hepatitis A vaccine and hepatitis A and hepatitis B combined vaccine have good immunogenicity and safety.It is recommended to increase a booster immunity to enhance long-term antibody protection.
Hepatitis A vaccine
Hepatitis B vaccine
Booster dose
Hepatitis B
Cite
Citations (0)
Objective To discuss the effect of thymosin and booster dosage of hepatitis B vaccine in nonresponders to hepatitis B vaccine after a complete course of immunization.Methods A total of 64 adult nonresponders to hepatitis B vaccination were randomly allocated into two groups of either with thymosin and booster dosage of hepatitis B vaccine or only with booster dosage of hepatitis B vaccine.Results The results of this study demonstrated that the antibody level in 82.14% of persons with thymosin and booster dosage of hepatitis B vaccine attained protecting level in comparison with those of 54.84% of persons only receiving booster dosage of hepatitis B vaccine.There was significant difference between these two groups(P0.05).Conclusion Thymosin and booster dosage of hepatitis B vaccine can effectively induce specific immune response against HBsAg in nonresponders to hepatitis B vaccination,thus it may raise the successful rate of hepatitis B vaccination.
Booster dose
Hepatitis B vaccine
Hepatitis A vaccine
Booster (rocketry)
Hepatitis B
Cite
Citations (0)
Objective To stop an epidemic of hepatitis A in Xiangshan County by mass immunization of susceptible populations with an inactivated hepatitis A vaccine and to evaluated the efficacy and safety by meet an emergency administrating the inactivated hepatitis A vaccine.Methods The study was nonrandomized,and uncontrolled.In August,2004,an outbreak of hepatitis A began in Xiangshan County,172 cases of acute symptomatic hepatitis A were reported and most of them were adolescents.For availably controlling the epidemic situation.Hepatitis A vaccine was offered to all persons in susceptible students and primary schools according to the serosurvey results.The hepatitis A epidemic current was statically analyzed from August to October.Result The endemic of hepatitis A was stopped after 15 days by an emergency administrating the inactivated hepatitis A vaccine 51305 doses.83651 doses vaccines used to emergency administrating and full administrating,one case occurred after 3 days among all subjects(in latent period before administrate),adverse events rate was 8.249/10 thousand.Conclusion This study suggested that hepatitis A vaccine could control the epidemic and can be used in breaking out of hepatitis A by administrating in meet the emergency,the vaccine was safe.
Hepatitis A vaccine
Hepatitis B vaccine
Cite
Citations (2)
Objective To increase the inoculation rate of hepatitis B vaccine among adults,while enforcing the policy of planned immunity for all neonates.Methods Used the method of stratified cluster random sampling to acquire total 2 700 objects aged from 20 to 65 years with different professions.Collected personal information and hepatitis B vaccination status through questionnaires.The questionnaire included questions about how to prevent and control hepatitis B and hepatitis B vaccine.Results The correct rate of hepatitis B prevention questions for medical staff was statistically higher than that of the non-medical staff,likewise for the inoculation rate of hepatitis B vaccine.This survey showed that the objects least knew about the etiological and immuno-prophylaxis knowledge of hepatitis B.The results of multiplicity revealed that the scores of answering hepatitis B prevention questions were statistically related with sex,vocation,income,education,dwelling place,likewise for the probability of getting vaccination.51.92% of all objects got the injection of hepatitis B vaccine.Among them,56.86% were voluntary,36.74% were injected as their workplaces required,and 5.32% were injected under the suggestion of doctors.45.11% of not-injected people didn’t know the necessity of injection.94.35% were willing to get the vaccinate for free.Conclusion To achieve the objectives of increasing the adults’ inoculation rate of hepatitis B vaccine,we should enforce the governmental instruction,spread the hepatitis B preventing knowledge and vaccine knowledge among high risk groups including the peasants and hepatitis B patients and their relatives,and enhance the medical staff’s comprehensive capability to prevent and treat hepatitis B.
Hepatitis B vaccine
Hepatitis B
Hepatitis A vaccine
Etiology
Cite
Citations (1)
Hepatitis A vaccine
Hepatitis B
Hepatitis B vaccine
Hepatitis C
Cite
Citations (26)