BNP can help rapidly diagnose HF
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In Brief The brain-type natriuretic peptide test is a laboratory study being used with increasing frequency to assist with a timely differential diagnosis of heart failure when patients present with dyspnea.Keywords:
Brain natriuretic peptide
Objective To study the diagnostic value of plasma brain natriuretic peptide (BNP) for heart failure.Methods 200 cases of heart failure patients within a year were selected as the observation group,200 healthy medical staffs were randomly assigned as the control group.The concentration of plasma BNP of the two groups were measured and we analyzed the correlation between plasma BNP level and cardiac functional status of patients.Results The concentration of plasma BNP in patients with heart failure was (575.7 ± 176.5) pg/ml,significantly higher than the control group (68.2 ± 17.9) pg/ml,the two groups were statistically significantly different (P ＜ 0.05).The concentration of plasma BNP increased gradually with more severe symptoms (class Ⅰ to Ⅳ).Conclusion BNP level may be a reliable method in the diagnosis of heart failure.The level of plasma BNP in patients with heart failure elevated with the severity of heart failure and it plays a significant role in the clinical diagnosis of heart failure.
Key words:
Brain natriuretic peptide; Clinical diagnosis; Heart failure
Brain natriuretic peptide
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Objective To evaluate diagnostic value of plasma brain natriuretic peptide(BNP) in patients with congestive heart failure(CHF).Methods 85 patients with acute dyspnea and whose B-type natriuretic peptide was measured with ELISA assay.The clinical diagnosis of congestive heart failure was adjudicated by two independent cardiologists,who were blinded to the results of the B-type natriuretic peptide assay.Thirty patients with normal ventricular function served as control group.Results The plasma BNP concentrations of CHF were significantly higher than that of non-CHF(P0.001 respectively),A plasma BNP concentration exceeding mean of the controls(x+1.96s) had a sensitivity of 96% and a specificity of 93% for diagnosis of congestive heart failure in patients with acute dyspnea.Conclusions Used in conjunction with other clinical information, measurement of B-type natriuretic peptide is useful in establishing or excluding the diagnosis of congestive heart failure in patients with acute dyspnea.
Brain natriuretic peptide
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AIM: To discuss the relations of the concentration of plasma brain natriuretic peptide(BNP) with the severity of congestive heart failure and the rate of 30-day re-admission. METHODS: Plasma BNP concentrations of congestive heart failure were measured immediately after admission and before discharge. The BNP concentrations of the normal controls were measured immediately as examination only. RESULTS: The Plasma BNP concentrations of congestive heart failure were significantly higher than those of the normal controls (477±244 pmol/L vs 184±54 pmol/L, P0.01), and that they also increased according to the severity of congestive heart failure (P0.01). The Plasma BNP concentrations of 33 cases of CHF group were under 300 pmol/L, and those of 45 cases were over 300 pmol/L at discharging. The rate of 30-day re-admission was 6% and 27% respectively (P0.05). CONCLUSION: The Plasma BNP concentrations, which increase according to the severity of CHF,may be an index for diagnosing CHF. The rate of 30-day re-admission is significantly lower if the plasma BNP concentrations are under 300 pmol/L at discharging.
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To determine age-related concentrations of brain-type natriuretic peptide in preterm infants using bedside Triage brain-type natriuretic peptide test and correlate it to the presence or absence of the patent ductus arteriosus and ventilatory support.Serum brain-type natriuretic peptide levels were measured in infants who were born at <32 weeks' gestation from birth to 2 months of age. Serial echocardiograms were performed, until closure of the patent ductus arteriosus, or until discharge. Brain-type natriuretic peptide levels were correlated to the day of life, gestational age, presence or absence of the patent ductus arteriosus, and the degree of ventilatory support. Nineteen preterm infants (gestational age: 24-31 weeks; birth weight: 645-1670 g) were enrolled prospectively during the first 2 weeks of life. Serum brain-type natriuretic peptide levels (pg/mL) were determined in 177 blood samples, and 87 paired echocardiograms were performed.Significant negative correlation was found between brain-type natriuretic peptide levels and the day of life and remained significant when the patients were stratified by gestational age (< or =28 weeks and >28 weeks). Higher brain-type natriuretic peptide levels correlated with increasing grade of the patent ductus arteriosus. Significant differences in brain-type natriuretic peptide levels were seen with increasing ventilatory support. Comparisons between the size of patent ductus arteriosus and the degree of ventilatory support to brain-type natriuretic peptide levels revealed that the size of the patent ductus arteriosus was the major determinant of both brain-type natriuretic peptide levels and the degree of ventilatory support.Similar to term infants, brain-type natriuretic peptide levels of preterm infants are related to the chronological age and decline during the first month of life. Rapid bedside Triage brain-type natriuretic peptide is a potentially valuable and practical assay in determining the hemodynamic changes in preterm infants.
Ductus arteriosus
Brain natriuretic peptide
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B-type natriuretic peptide is released from the cardiac ventricles in response to increased wall tension.
Brain natriuretic peptide
Cardiac Ventricle
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Objective To observe the plasma level's change of the brain natriuretic peptide(BNP) in patients with heart failure and explore its clinical significance.Methods All the subjects were divided into three groups:the heart failure group,the non-heart failure group and the control group.Their N-tape BNP levels were measured by the Biosite Diagnostics.The data were analyzed by SPSS11.0.Results The BNP level in heart failure group was significant higher than that of the non-heart failure group and the control group(P0.05).There was no significance between the non-heart failure group and the control group(P0.05).There was a significant negative correlation between the BNP level and the ejection fraction in heart failure group.Conclusion The plasma level of BNP is significant abnormal in patients with heart failure,this can reflect the status of heart function.
Brain natriuretic peptide
Clinical Significance
Plasma levels
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Brain natriuretic peptide
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Background: Heart failure is a major health problem in the world. It is associated with high morbidity and high mortality especially in elderly patients. Most studies reported using N terminal pro-B type natriuretic peptide (NT-proBNP) in diagnosis of heart failure, but about of these tests in determining classification of severity of heart failure in the elderly remain unclear.Objective: To determine the differences NT-pro BNP levels based on the severity of diease of heart failure in elderly patients.Methods: This is an observational study with cross sectional design. Subjects were patients with diagnosed heart failure and aged = 60 years. Patients were divided into two groups, mild and severe heart failure groups according to severity of heart failure in New York Heart Association (NYHA) class. The NT Pro-BNP levels were measured for all subjects in both groups. Data was analyzed with using unpaired t test and was considered significant if p Results: This study involved 24 subjects, consisting of 2 gorups, there were mild heart failure groups (NYHA class I-II) and groups of patients with severe heart failure (NYHA III-IV). The mean age of the subjects was 64.50 ± 4.65 years with a minimum age of 60 years and a maximum of 78 years. The NT pro-BNP levels in the severe heart failure group (1.2587.58 ± 574.85 pg / ml) was higher than the mild heart failure group (867.83 ± 333.27 pg / ml), it was statistically significant with p = 0.040.Conclusion: The levels of NT-pro BNP serum in elderly patients with severe heart failure (NYHA III-IV) were significantly higher than in patients with mild heart failure (NYHA I-II).
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Brain natriuretic peptide
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