Folliculotropic mycosis fungoides responding to bexarotene gel.

Journal of Drugs in Dermatology (2008)

Hobart W. Walling Brian L. Swick Pedram Gerami Richard K. Scupham

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Abstract:

Folliculotropic mycosis fungoides (FMF) is an uncommon and potentially aggressive form of cutaneous T cell lymphoma (CTCL). Phototherapy, radiotherapy, and systemic chemotherapy are the most commonly employed treatment options, but may have limited success and common adverse reactions. Bexarotene gel is a topical retinoid X receptor (RXR) agonist with activity on the follicular unit that has not been previously reported in the management of FMF. The case of a 73-year-old male with FMF that responded to bexarotene gel is presented.

Keywords:

Bexarotene

Cutaneous T-cell lymphoma

Topics:

Cutaneous lymphoproliferative disorders research

Retinoids in leukemia and cellular processes

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Bexarotene monotherapy for patients with refractory early stage mycosis fungoides.

Dermatologic Clinics (2008)

Annette Stein

Bexarotene

Refractory (planetary science)

Peripheral T-cell lymphoma

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Alopecia Mucinosa, Inflammatory Disease or Mycosis Fungoides: Must We Choose? And Are There Other Choices?

American Journal of Dermatopathology (2004)

Philip E. LeBoit

10.1097/00000372-200404000-00040

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Citations (27)

Bexarotene treatment of late-stage mycosis fungoides and Sézary syndrome: Development of extracutaneous lymphoma in 6 patients∗

Journal of the American Academy of Dermatology (2005)

Saskia A. Bouwhuis Mark D.P. Davis Rokea A. el‐Azhary Marian T. McEvoy Lawrence E. Gibson

Bexarotene

Cutaneous T-cell lymphoma

Peripheral T-cell lymphoma

10.1016/j.jaad.2005.02.055

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Citations (29)

Bexarotene monotherapy for patients with advanced stage mycosis fungoides.

Dermatologic Clinics (2008)

H. Bachelez

Bexarotene

Peripheral T-cell lymphoma

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Lentigines following narrow-band ultraviolet B phototherapy for mycosis fungoides

Clinical and Experimental Dermatology (2009)

Huihui Xu Ting Xiao H.-D. Chen

Conflict of interest: none declared. Mycosis fungoides (MF) is the most common form of cutaneous T‐cell lymphoma. Early MF presents as erythematous patches or plaques without internal involvement. Narrowband ultraviolet B (NB‐UVB) phototherapy is effective for early‐stage MF, and carries a low risk of adverse events. We present a unique case of lentigines confined to the site of resolved MF plaques after NB‐UVB phototherapy. A 49‐year‐old Chinese man (Fitzpatrick phototype III) presented with a 1‐year history of recurrent itchy erythematous patches and plaques. Physical examination revealed erythematous plaques on the flexor areas of the right thigh, and erythematous patches on both arms (Fig. 1a). Histological examination of a biopsy taken from the plaque found intraepidermal Pautrier microabscesses and an intense infiltrate of mononuclear cells containing atypical lymphocytes in the upper dermis (Fig. 2a). Immunohistochemistry showed that most of the infiltrating cells were CD3 and CD4 positive. Results of blood cell count, blood biochemistry and CD4/CD8 flow cytometry were normal.

Skin biopsy

Cutaneous lymphoma

10.1111/j.1365-2230.2009.03502.x

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Citations (2)

[Association of mycosis fungoides and Hodgkin disease].

PubMed (1995)

P Duhault P Bayle-Lebey B Gorguet R. Viraben H Cadilhac

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Citations (1)

[Mycosis fungoides during B-cell lymphoma].