[Diffuse gingival plasmocytoma: a rare location of extra-osseous solitary plasmocytomas (author's transl)].
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A 51-year-old man presented with isolated diffuse gingival hypertrophy, the diagnosis of a plasmocytoma being suspected after pathological and immunohistological examinations of a gingival biopsy (light chain lambda plasmocytes). The isolated nature of this diffuse gingival plasmocytoma was confirmed by biological tests and radiological investigations. The evolution of solitary plasmocytomas is variable, and while certain of these lesions remain isolated even after many years, other plasmocytomas, apparently local, are associated with myelomas which either become evident or may sometimes develop. The extremely rare nature of diffuse gingival locations of extra-osseous solitary plasmocytomas is confirmed by a review of the published literature. Studying histological sections by immunofluorescence enables the polyclonal or monoclonal nature of the plasmocytes to be established, this distinction being an important element in the prognosis.Cite
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Port (circuit theory)
Log-rank test
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目的:分析椎管内肿瘤的发病情况及临床病理特点.方法:总结327例椎管内肿瘤,就其发病年龄、性别、部位及病理类型进行分析.结果:脊髓肿瘤发病率为脑瘤的1/10,胸颈腰段分别为57.5%,20.49%和20.18%.神经鞘瘤,脊膜瘤,胶质瘤和先天性肿瘤分别占29.05%,25.38%,14.69%和18.05%.良性肿瘤占3/4.结论:脊髓肿瘤发病率低,胸腰段多发,多为神经鞘瘤,脊膜瘤,胶质瘤和先天性肿瘤.良性肿瘤多见.
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Consecutive biopsies were studied electron microscopically on three temporal arteritis patients. All biopsies showed a combination of pathological changes of various stages of the disease with confirmation of the smooth muscle cell involvement. Biopsies obtained in the clinically acute periods showed inflammatory elements predominantly. Later biopsies of the same patient showed granulomatous reactions and muscular regeneration.
Arteritis
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Aim:To investigate the pathological changes of the bone marrow in patients with POEMS syndrome.Methods:3 patients underwent bone marrow puncture,biopsy and immunohistochemical examination and the pathological changes were analyzed.Results:The bone marrow puncture results of 2 patients are normal and another one shows an elevation of plasma cells;the biopsy and the immunohistochemical results of all the 3 patients are abnormal.The biopsy displays a disperse or focal infiltration of mature plasma cells and plasmoblasts.The results of the immunohistochemical examination suggest a reactive plasma cell proliferation or a somewhat monoclonal(M) gammopathy.Conclusion:The pathological change of the bone marrow in POEMS syndrome is a kind of transitional expression which is between that of the normal bone marrow and the malignant lymphoma.
POEMS syndrome
Bone marrow examination
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to investigate the histopathology of amyloid in liver biopsy specimens. MATERIAL AND METHODS. A total of 46 liver biopsy specimens were investigated in patients with histologically verified amyloidosis in 2006 to 2009 from the Amyloid Registry of the Charité University Hospital (Berlin). The liver biopsy specimens were fixed in formalin and embedded in paraffin. The paraffin sections were stained with hematoxylin and eosin and with Congo red. Amyloid was immunohistochemically classified using antibodies against amyloid P component, AA amyloid, apolipoprotein Al, lysozyme, fibrinogen, transthyretin, and κ and λ light chains.Amyloid deposits were diagnosed in the 46 liver biopsy specimens from 17 women and 29 men (mean age 60 years). Immunohistochemical subtyping was successful in 91% of the cases. AL amyloidosis was diagnosed in 87% of the biopsy specimens and further classified as AL lambda-light chain amyloidosis (57%) and AL kappa-light chain amyloidosis (30%). The 46 liver biopsy specimens showed one case of AA amyloidosis (2%) and one case of transthyretin amyloidosis (2%). The type of amyloid could not be classified in 9% of the biopsy specimens.The investigation revealed that the most common types of hepatic amyloidosis are AL lambda- and AL kappa-light chain amyloidosis associated with the signs of parenchymal atrophy and steatosis.Цель - исследование гистопатологии амилоида в печеночных биопсиях. Материал и методы. Исследовали 46 биоптатов печени у больных c гистологически подтвержденным амилоидозом за период с 2006 по 2009 г. из амилоидного регистра университетской клиники Шарите (Берлин). Печеночные пробы фиксировали в формалине и заливали в парафин. Срезы окрашивали гематоксилином и эозином и конго красным. Амилоид классифицирован иммуногистохимически с использованием антител к амилоидному Р-компоненту, АА-амилоиду, аполипопротеину AI, лизоциму, фибриногену, транстиретину, каппа- и лямбда-легким цепям. Результаты. Амилоидные отложения диагностированы в 46 печеночных биоптатах (17 женщин, 29 мужчин; средний возраст 60 лет). Иммуногистохимическая классификация была успешна в 91% случаев. AL-амилоидоз диагностировали в 87% биоптатов, далее заболевание классифицировано как AL-лямбда-амилоидоз (57%) и AL-каппа-амилоидоз (30%). Из 46 проб выявлено только по одному пациенту с АА- и транстиретиновым амилоидозом (каждый по 2%). В 9% биоптатов тип амилоида классифицировать не удалось. Заключение. Исследование выявило, что наиболее частыми видами амилоидоза печени являются AL-лямбда- и AL-каппа-амилоидоз, ассоциированный с признаками паренхимальной атрофии и стеатозом.
Amyloid (mycology)
AL amyloidosis
Histopathology
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Objective To investigate the pathological features in donor kidney (zero biopsy) and pathological changes in allograft kidney (post transplant biopsy).Method 191 renal allograft biopsies including 52 cases of perioperative biopsies and 139 cases of post operative biopsies were performed. All biopsies were systematically diagnosed and evaluated according to Banff 97 schema. SABC immunohistochemical staining was used to analyze the Leu 7 + and CD68 + expression during acute rejection. Results Among the 52 donor kidneys, 40 cases were normal ( 76.92 ?%), 12 cases had preexisting diseases ( 23.07 ?%), including hyaline arteriolar change in 3 cases, focal interstitial fibrosis in 4 cases, tubular atrophy in 3 cases and tubular epithelial degeneration in 2 cases. Among the 151 allografted kidneys, 19 were normal ( 13.66 ?%), one was diagnosed as having super acute rejection ( 0.71 ?%), 15 having suspicious of AR/bordline change ( 10.79 ?%), 23 having acute rejection ( 16.54 ?%), 37 having CAN ( 26.61 ?%), 29 having CsA NT ( 20.80 ?%), 8 having ATN( 5.75 ?%), 2 having recurrence nephropathy ( 1.43 ?%) and 5 cases were not classified ( 3.59 ?%). The SABC immunohistochemical staining showed that Leu 7 positive cells in the tubular epithelium and CD68 positive cells in the intestitial tissues were increased during acute rejection. Conclusion Biopsy is an valuable method to evaluate the pathological changes of donor kidney and diagnose the complications of allografted kidney. The changes of CAN could be found in 3 months posttransplantation. The presence of Leu 7 positive cells infiltrating the tubular epithelium is a reliable marker of acute rejection.
CD68
Chronic Allograft Nephropathy
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