Antiulcer Activity of Leaves Extract of Murraya Koenigii In Experimentally Induced Ulcer In Rats.
Praveen Kumar SharmaG. VidyasagarAnil BhandariSunder SinghSantosh GhuleAshish AgrawalSwapnil GoyalM. S. Panwar
13
Citation
10
Reference
20
Related Paper
Citation Trend
Abstract:
Summary The anti-ulcer activity of Aqueous extract of the leaves of Murraya koenigii was evaluated by using models of acute gastric lesions induced by ethanol induced, asprin induced, cold restrain stress and pylorus ligation in rats. Animals pretreated with doses of 200 mg/kg and 400 mg/kg of Aqueous extract showed significant reduction in lesion index, total affected area and percentage of lesion in comparison with control group in the ethanol induced, asprin induced, cold restraint stress-induced ulcer and pylorus ligation models. These findings indicate that aqueous extract of the leaves of Murraya koenigii displays good antiulcer activity, corroborating the folk use of Murraya koenigii preparations, and contributing for its pharmacological validation.Keywords:
Murraya
Antidiarrhoeal
Ulcer index
Aqueous extract
Cite
Objective: To perform the Phytochemical Screening & Anti-inflammatory activity of Murraya Koenigii & Ficus Lacor roots in Albino Wistar rats.
Methods: The different Pharmacognostical parameters were evaluated as per standard procedure. The crude drug was evaluated for organoleptic properties shape, size, color, odor, taste. Preliminary Phytochemical Screening was carried out & finally Anti-inflammatory activity was evaluated by adopting different methods.
Results: The extracts showed a marked Anti-inflammatory effect. The FLET fraction from Ficus lacor aerial roots showed maximum inhibition (75%) of Carrageenan induced edema (Table 3.12B), followed by FLPE and MKCF from Murraya koenigii roots (74 % and 70% approx) (p <0.001 for all). The inhibition of inflammation was comparable for all the fractions for any change in extent & percentage of inhibition at 30 min, 1hr, 2hr and 3hr. The anti-inflammatory effect induced via indomethacin gradually increased and reached at higher level (80.8%) after 3 hrs. It was maintained up to six hours. For, MKPE the inhibition was observed to be maximum at the end of 2 hrs and then tapered. MKEA, FLEA and FLCF showed minimum response that was constant throughout and insignificant. MKPE was slightly significant (55.1 %, p<0.05) which was more effective.
Conclusion: The results of the study indicate that the extract of Murraya koenigii roots and Ficus lacor possesses strong Anti-inflammatory activity. This study also describes therapeutic effect of Murraya koenigii roots and Ficus lacor aerial roots in inflammation and arthritis which will give a new direction for the future scientific research.
Murraya
Phytochemical
Carrageenan
Anti-inflammatory
Cite
Citations (2)
Objectives- To evaluate the Anti-inflammatory effect of Methanolic extract of Murraya koenigii leaves on carrageenan induced paw edema in albino rats.Materials and methods-Thirty adult male albino rats weighing 175-200 grams were selected and allocated in to five groups of six animals each. The control group received vehicle 2 gum acasia (10mlkg),Standard group received aspirin (200mgkg) and test groups received Methanolic extract of Murraya Koenigii leaves (100mgkg, 200mgkg, 400mgkg per oral respectively) 60 mts before giving subplantar injection of 0.1ml of 1 carrageenan into left hind paw of the rats. The anti-inflammatory effect is estimated by measuring paw volume using plethysmograph. The results were tabulated and analysed with suitable statistical method. Results- Murraya Koenigii leaves showed statistically significant reduction of rat paw edema in a dose dependant manner. Maximaum inhibition occurred at the dose of 400mg kg-1(50.81) after 4th hour of carrageenan injection.(p0.001). The results were comparable to that produced by standard drug aspirin.Conclusion- Murraya Koenigii leaves has anti-inflammatory activity which is comparable to aspirin. Further studies are essential to prove the anti-inflammatory activity of Murraya Koenigii in human
Murraya
Carrageenan
Anti-inflammatory
Dose dependence
Cite
Citations (1)
Albizzia procera belongs to family Fabaceae and has several phytoconstituents like flavonoids, terpenes, alkaloids, saponins etc. The plant is commonly used in traditional medicines. The objective of the present study was to assess the ameliorative effect of A. procera leaves extract against an experimentally induced gastric ulcer in albino rats. The antiulcer, antisecretory and cytoprotective properties of an ethanolic extract prepared from the leaves was evaluated. When given in a 200 mg/kg oral (per. os) dose, the extract produced 74% and 85% protection index in ethanol-induced ulcer model and pylorus ligation model, respectively. Additionally, the extract also prohibited the formation of haemorrhage and edema, significantly lessened catalase activity (p<0.0001) and the lipid peroxidation level (p<0.0001) in the glandular tissue of Wistar albino rats. Furthermore, the extract also significantly diminished the total acidity(p<0.0001) of the gastric fluid by increasing its pH (p<0.0001). The occupancy of different phytoconstituents in the extract, such as flavonoids and tannins were identified that may be responsible for its gastro-protective activity. All these results provide a basis explaining the antiulcer ability of A. procera being useful in the management of gastric ulcers.
Procera
Ulcer index
Calotropis procera
Terpene
Cite
Citations (0)
The anti-ulcer activity of methanolic extract of Terminalia chebula (Combretaceae)fruits METC was investigated in pylorus ligation and ethanol induced ulcer models in wistar rats. In both models the common parameter determined was ulcer index. METC at doses of 250,500 mg/kg p.o produced significant inhibition of the gastric lesions induced by Pylorus ligation induced ulcer & Ethanol induced gastric ulcer .The extract (250 mg/kg & 500 mg/kg) showed significant (P<0.01) reduction in gastric volume, free acidity and ulcer index as compared to control. This present study indicates that Terminalia chebula fruit extract have potential anti ulcer activity in the both models. These results may further suggest that methanolic extract was found to possess antiulcerogenic as well as ulcer healing properties, which might be due to its antisecretory activity.
Terminalia chebula
Combretaceae
Ulcer index
Cite
Citations (110)
The potential of methanolic leaves extract of H. elasticus in the mitigation of ulcer and inflammation was evaluated in this work. Ethanol and pylorus ligation induced rats were used for the screening of ulcer, whereas the anti-inflammatory activity against acute and chronic phases of inflammation was screened using carrageenan-induced paw edema and cotton pellet induced granuloma in rats. The H. elasticus (200 and 400 mg/kg p.o.) was administered to the ethanol and pylorus ligation induced rats. Gastric volume, pH, free acidity and total acidity were estimated in pylorus ligation induced ulcers of rats. Treatment with H. elasticus showed a reduction in ulcer index against ethanol and pylorus ligation induced ulcerations. The antiulcer activity may be due to the antisecretory and cytoprotective effects of the extract. Moreover, it also showed a highly significant (P ≤ 0.001) reduction in carrageenan and cotton pellet induced inflammations. This investigation suggests that H. elasticus leaves possess anti-inflammatory activity and promotes ulcer protection.
Ulcer index
Carrageenan
Anti-inflammatory
Cite
Citations (8)
Gastric ulcer is one of the most prevalent gastrointestinal disorders, which affects approximately 5-10% of people during their life. In recent years, abundant work has been carried out on herbal medicine to clarify their potential efficacy in gastric ulcer prevention or management. Here, present study was carried out to investigate antiulcer activity of methanol extract of Erythrina indica (family: Febaceae) leaves in pylorus ligated and indomethacin induced ulceration in the albino rats. Preliminary methanol extract of E. indica was subjected to the acute oral toxicity study according to the OECD guideline no. 423. Based on which, three dose levels i.e. 125, 250 and 500mg/kg were selected for the further study. In pylorus ligation induced ulcer model, various parameters were studied viz. gastric volume, pH, total acidity free acidity, and ulcer index. Ulcer index and percentage inhibition of ulceration was determined for indomethacin induced ulcer model. Ranitidine at 100mg/kg was used as the standard drug. Pretreatment of methanol extract of E. indica leaves showed significant (P<0.01) decrease in the gastric volume, total acidity and free acidity. However, pH of the gastric juice was significantly (P<0.05) increased only at higher dose, 500mg/kg. It showed also significant (P<0.01) decrease in number of ulcers and ulcer score index in pylorus ligation and indomethacin induced ulceration models. The methanol extract of E. indica leaves possess significant antiulcer properties in a dose dependent manner. In conclusion the antiulcer properties of the extract may be attributed to the polyphenolic compounds that are present in it.
Ulcer index
Cite
Citations (40)
4 Abstract: Citrus medica Linn. (Rutaceae) known as Gajanimbe and is used as a folk medicine for the treatment of gastric ulcers. The present study was planned to evaluate the antiulcer activity of aqueous extract of the fruits against ethanol-induced ulcers in rats. The extract was subjected to phytochemical screening and found to contain carbohydrates, proteins, amino acids and flavonoids. The rats were pretreated with the extract at two doses (250 and 500 mg kg p.o.) and the antiulcer effect was compared with that of ranitidine (20 mg kg p.o.). 11 The extract of both doses showed a significant reduction in ulcer formation. Histopathological sections showed significant decrease in mucosal ulceration, inflammatory mucosal changes and submucosal edema compared to ethanol treated group and the ranitidine group. It is concluded that, the fruits of C. medica possesses significant antiulcer activity against ethanol-induced ulcers in rats and the antiulcer activity could be due to the presence of flavonoids as these compounds have well documented antiulcer activity.
Phytochemical
Aqueous extract
Cite
Citations (25)
This work has been done for the investigation of the anti-inflammatory and analgesic activity of methanol extract of dried leaves of Murraya koenigii Linn by oral administration at dose of 100, 200 and 400 mg/kg body weight, to healthy animals. Extract was studied for its anti-inflammatory activity by using carrageenan-induced hind paw edema in albino rats and the mean increase in paw volume and % inhibition in paw volume were measured plethysmometrically at different time intervals after carrageenan (1% w/v) injection. Extract was also evaluated for analgesic activity using Eddy's hot plate method and formalin induced paw licking method in albino rats. The methanol extract showed significant (P < 0.001) reduction in the carrageenan-induced paw edema and analgesic activity evidenced by increase in the reaction time by eddy's hot plate method and percentage increase in pain in formalin test. The methanol extract showed anti-inflammatory and analgesic effect in dose dependent manner when compared with the control and standard drug, diclofenac sodium (10mg/kg, p.o). These inhibitions were statistically significant (P < 0.05). Thus our investigation suggests a potential benefit of Murraya koenigii in treating conditions associated with inflammatory pain.
Licking
Murraya
Diclofenac Sodium
Carrageenan
Diclofenac
Anti-inflammatory
Cite
Citations (33)
The aim of the study was to study the anti-ulcer activity of the methanolic extract of the leaves of Capparis zeylanica Linn on experimental animal models. The methanol extract of Capparis zeylanica Linn. leaves was investigated for anti-ulcer activity against aspirin plus pylorus ligation induced gastric ulcer in rats. HCl-Ethanol induced ulcer in mice and indomethacin induced ulcer in rats at 200 mg/kg body weight p.o. A significant (p<0.01, p<0.001) anti-ulcer activity was observed in all the models. Pylorus ligation showed significant (p<0.01) reduction in gastric volume, free acidity and ulcer index as compared to control. It also showed 88.5% ulcer inhibition in HCl-ethanol induced ulcer and 83.78% inhibition in indomethacin induced ulcer.
Ulcer index
Cite
Citations (10)
Background: Murraya koenigii, commonly known as karipatta or curry leaf, is analgesic and can be used effectively against inflammation and itching. The various pharmacological activities such as vasodilation, antimicrobial, antidiabetic, antiulcer, analgesic, phagocytic, and antioxidant activities of this plant have also been reported.
Aims and Objectives: To evaluate the anti-inflammatory and analgesic activity of aqueous extract of dried leaves of M. koenigii Linn. in male Wistar rats.
Materials and Methods: Adult male Wistar rats (100–150 g body weight) were used in this study. Aqueous extract of M. koenigii Linn. was used to evaluate acute anti-inflammatory and analgesic activity by plethysmometer and hot plate method by oral administration at doses of 100, 300, and 500 mg/kg body weight in healthy albino rats.
Result: In acute studies, the aqueous extract showed anti-inflammatory activity by significant reduction in the paw edema volume, in a dose-dependent manner when compared with the control and standard drug. Aqueous extract of M. koenigii Linn. significantly and dose-dependently reduced the number of acetic acid-induced writhing and significantly increased the latency of paw licking in hot plate method. Statistical analysis was carried out by one-way ANOVA, followed by Turkey's test.
Conclusion: Aqueous extract of M. koenigii Linn. possesses both anti-inflammatory and analgesic activity in a dose-dependent manner.
Murraya
Aqueous extract
Anti-inflammatory
Analgesic agents
Cite
Citations (14)