Methyl Donor Deficiency Affects Fetal Programming of Gastric Ghrelin Cell Organization and Function in the Rat
Carine Bossenmeyer‐PouriéSébastien BlaiseGrégory PouriéCatherine TomasettoSandra AudonnetSandrine OrtiouViolette KozielMarie–Christine RioJean‐Luc DavalJean‐Louis GuéantBernard Beck
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Weanling
More than 100 weanling pigs from 10 sows were studied the effect of adding non-starch-polysaccharide enzyme(NSPE) to corn-soybean diet on the growth and nutrient digestibility of weanling pigs.A corn-soybean diet as basic diet was used in all groups in this trial.Adding 120g/t NSPE to the diet used in the test groups,but on adding any NSPE to its diet for control one.The results showed that the digestibility of protein and organic matter of weanling pigs could be increased by 9.67% and 15.40%(P0.05), respectively.Adding NSPE to the corn-soybean diet,there was no obvious effect on the growth of weanling pigs before weanling,but there was an obvious positive effect on the weanling pigs from 0 to 14 day after weanling by increasing the daily gain of 10.40%(P0.05),increasing the total litter weight by 17.65%.The result also indicated adding NSPE to the weanling diet could decrease the weanling stress .
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Litter
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Aim:To investigate the adhering ability and characteristics of Helicobacter pylori (HP) to gastric mucosa and the role of adhesion process in pathogenicity of HP.Methods: Ten HP strains were tested by adhering to stomach mucosa of 4 fetuses ageing from 6 to 8 months.Results: The average numbers of different HP strains adhering to fetal mucosa were very different.The numbers of HP on every tissue piece varied form 51 to 3 700. There were also significant differences in adhering numbers of HP strain in the same site of different fetus' stomaches and in different sites of one stomach. No matter how many germs which adhered to stomach,the gastric mucosa's pathological change of all corresponding patients exceeded middle degree.Conclusion: It is indicated that the number of HP adhered to stomach mucosa is influenced not only by the kinds and quantity of adhesion but also by the kinds and quantites of their corresponding receptors distributing on different gastric mucosa. Although adhesion of HP is a crucial progress in pathogenicity, the adhering ability of HP to stomach mucosa is not the only key factor.
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Objective To study the expressions of Ghrelin and its receptor (GHSR) in the patients with Hirschsprungs disease (HD).Methods Eighteen patients who were diagnosed with HD and underwent transanal pull-through procedure were recruited in this study.The resected colon was collected to study the expressions of Ghrelin and GHSR by immunohistochemistry staining.Results Ghrelin and GHSR protein were consistently expressed in the glandular epithelium and villi of the ganglionic colon.In the aganglionic segment,the expressions of Ghrelin and GHSR were significantly reduced (Ghrelin:0.1460 ± 0.014,GHSR:0.1386 ± 0.016).However,the expressions of Ghrelin and GHSR were restored in the dilated segment of colon (Ghrelin..0.5103 ± 0.013,GHSR..0.5094 ±0.019).Moderate expressions of Ghrelin and GHSR were found in the transition zone.In the same tissue of colon,the expression of Ghrelin was not significantly different from that of GHSR (P＞0.05).Conclusions The expressions of Ghrelin and GHSR are reduced in the aganglionic colon of the patients with HD.
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Hirschsprung' s discase; Ghrelin; Receptors, Ghrelin
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Ghrelin，新奇生长释放荷尔蒙的肽，原来从老鼠和人的胃被孤立。Ghrelin 为当外围地或集中地管理了时，生长激素(GH ) 的分泌物，食物摄取，和体重获得的增加所知。Ghrelin 也被知道刺激胃的活动性和胃的酸的分泌物。在以前的研究，酸分泌物上的 ghrelin 的行动被显示在 in-vivo 实验象组织安和促胃液素的一样猛烈。在研究，为 ghrelin 的行动的机制也被调查。迷走神经切断术完全在那根迷走神经神经在酸分泌物上为 ghrelin 的行动涉及机制的胃的酸的建议的分泌物上禁止了 ghrelin 的行动，这被显示出。当 famotidine 没由 Masuda 等在学习禁止导致 ghrelin 的酸分泌物，他们断定组织安不在酸分泌物上涉及 ghrelin 的行动。然而，我们证明了 famotidine 完全禁止了导致 ghrelin 的酸分泌物，组氨酸脱羧酶(HDC ) mRNA 被被迷走神经切断术禁止的 ghrelin 注射在胃粘膜增加我们组织安在酸上涉及 ghrelin 的行动的结果 indicate 分泌物。而且，胃的酸分泌物上的促胃液素和 ghrelin 的 synergistic 被显示出。尽管促胃液素在胃的酸的饭后的分泌物有重要角色， ghrelin 可能在 fasting 时期期间或在夜里与酸分泌物有关。然而，进一步的研究被需要阐明在酸的 ghrelin 的生理的角色分泌物。
Famotidine
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Digestion
Golden hamster
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Ghrelin 首先从胃被分泌并且在吃行为和重量规定的协作被含有。Ghrelin 也在胃的粘膜防卫的机制起一个必要作用。因此，澄清哪个疾病首先在血浆 ghrelin 集中影响变化是重要的。Helicobacter pylori (H pylori ) 感染涉及胃炎的致病，胃并且十二指肠溃疡，胃的癌，和联系 mucosa 的淋巴组织淋巴瘤。H pylori 根除与体重变化有关。比较，在胃粘膜生产房间的 ghrelin 的感染的 H pylori 和有身体质量索引的正常的否定题目，血浆 ghrelin 集中，胃的 ghrelin mRNA，和数字在 H pylori 是显著地更低的比感染了题目在 H pylori 否定的控制。血浆 ghrelin 集中与胃的萎缩的前进减少。与 H pylori 感染导致的萎缩性胃炎联合的损害胃的 ghrelin 生产在血浆 ghrelin 集中说明减少。然而，到全部的 ghrelin 层次的血浆酰 ated ghrelin 的比率比在健康题目在有长期的萎缩性胃炎的病人是更高的。这可以源于血浆的补偿增加响应胃的萎缩的活跃 ghrelin 集中。在 H pylori 根除以后，胃的 preproghrelin mRNA 表示被增加将近在大多数情况中的 4 褶层。然而，在 H pylori 痊愈没与胃的 ghrelin 生产被联系前后，在血浆 ghrelin 集中变化。血浆 ghrelin 变化相反地与体重变化和起始的血浆 ghrelin 层次被相关。
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瞄准：在胆石疾病探索 ghrelin 的角色。方法：我们在 150 个题目，执行了代表性的研究 38 与胆石(盒子) 和 112 控制。我们也各在二十件胆囊样品做了即时 PCR-RT 研究。身体集体索引(BMI ) ，浆液胰岛素， ghrelin，和浆液类脂化合物被测量。逻辑回归分析(univariate 并且多变量) 被进行估计与浆液 ghrelin 集中联系的胆石疾病的概率。结果：盒子与在性分发的控制统计上不同(P = 0.01 ) ，年龄(53 对 44 年， P = 0.002 ) ， BMI (28 对 25；P = 0.004 ) ，并且葡萄糖(5.26 对 4.98 mmol/L；P = 0.05 ) 。没有新陈代谢的症候群，在第三 tercile 上面的 ghrelin 浆液层次的流行在题目是更低的(P < 0.05 ) 。在里面一多，变量当模特儿，当 ghrelin 价值比中部的价值高时，我们发现了保护的效果(或 = 0.27， 95%CI 0.09-0.82， P = 0.02 ) 。二十(20%) 胆囊标本表示了 ghrelin mRNA。结论：浆液 ghrelin 集中与 GD 的保护的效果被联系。
Obestatin
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Forty-eight piglets were selected from 9 litters and randomly divided into two groups: weanled on the 23rd and 28th days by using crossbred(Duroc×Landrace×Large White) piglets.Every group takes the samples at 0,3,7 and 14 day,respectively after weanling.The results showed that weanling on the different day have prominent influence on production performance of the piglets.The ADG and ADFI of piglet weaning on the 28th day were higher than that of piglet weaning on the 23th day notably.In addition,various digestive enzyme activities in digestive ferment of piglets weanled on the 28th day were higher than the 23rd of the same period age piglets in 2 weeks after weanling.
Weanling
Digestive enzyme
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