Erratum to: Interaction of Paroxetine with Mitochondrial Proteins Mediates Neuroprotection
Joseph SteinerMuznabanu BachaniBrett Wolfson-StofkoMyoung-Hwa LeeTongguang WangGuanhan LiWenxue LiDavid S. StrayerNorman J. HaugheyAvindra Nath
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Paroxetine
Paroxetine
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bjectives:To evaluate the effect of So1ution-Focused Brief Therapy(SFBT) combined with paroxetine in the treatment of Obsessive-Compulsive Disorder(OCD). Methods:60 outpatients who met CCMD-3 criteria for OCD were randomly divided into experiment group (SFBT plus Paroxetine,n=30)and control group (paroxetine only,n=30) and treated for 10 weeks. The efficacy was assessed with Yale-Brown 0bsessive- Compulsive Rating Scale (Y-BOCS) at the end of week 2,4,6,8,and 10. Results:The Y-BOCS score in two groups were significantly decreased 2,4,6,8,and 10 weeks after treatment (P0.05 or P0.01),and the Y-BOCS score in experiment group was significantly lower than that in control group (P0.05 or P0.01). Conclusions: SFBT combined with paroxetine and paroxetine have significant efficacy in the treatment of OCD,and SFBT combined with paroxetine has better effect than paroxetine alone.
Paroxetine
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Objective:To evaluate the efficacy and safety of paroxetine in the treatment of depression.Methods:63 patients with depression were randomly divided into the treatment groups of paroxetine or imipramine for 6 weeks.HAMD were adopted to evaluate the therapeutie effect.TESS was used to assess the side effects.Results:The effective rate in paroxetine group was 87.5%.No significant difference was found between the two groups.The adverse efffects of paroxetine were less and mild.Conclusions:Paroxetine is an effective antidepressant in treating depression.
Paroxetine
Depression
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Objective To compare the curative effects and the adverse effects between Paroxetine and Fluoxetine.Methods According to CCMD-3,there were 60 samples from patients of depression who were stochastically group in two sets.They were treated by Paroxetine and Fluoxetine in 6 weeks with dose 20mg/d.Results The effective power of Paroxetine is 83.3%.The effective power of Fluoxetine is 76.7%.According to HAMD,the curative effects of Paroxetine are obvious in 1 week.Fluoxetine's are in 4 weeks.Paroxetine is better.Conclusion Paroxetine's adverse effects are less.Curative effects of Paroxetine are better than neotype antidepressants.
Paroxetine
Depression
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Summary The tolerability and safety of treatment with paroxetine have been assessed by analysis of a clinical trial database that extends to 4126 patients treated with paroxetine, 1954 patients on active control, and 625 placebo patients. A total of 451 patients were exposed to paroxetine for periods of 1 or more years. Paroxetine was generally better tolerated than active control and was associated with a lower frequency of manic reactions in bipolar patients and fewer seizures than active control. Paroxetine appears to offer a differential advantage in reducing suicidal thoughts; the number of suicides and attempted suicides per patient exposure year were lower for paroxetine than for other antidepressants or placebo.
Paroxetine
Tolerability
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Objective:To evaluate the efficacy and safety of paroxetine in the treatment of general anxiety disorder(GAD).Methods : 60 patients with GAD were randomly assigned into the treatment groups of paroxetine or Doxepine for 6 weeks.HAMA.CGI were adopted to evaluate the therapeutic response.TESS were used to assess the side effects.Results: 83.33 % of patients responded to paroxetine.No significant difference was found between the groups.The adverse effects of paroxetine were less and mild.Conclusions: paroxetine is effectiver in treating GAD.
Paroxetine
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Objective:To evaluate the efficacy and safety of Relaxation training combined with Paroxetine in the treatment of obsessive-compulsive disorder(OCD).Methods:Fifty-six patients with OCD were randomized to two groups.The patients(n=28)in observed group were treated with Relaxation training combined with Paroxetine.The patients(n=28)in control group were treated with Paroxetine alone.The efficacy and safety were assessed with Y-BOCS,CGI-SI,HAMD and TESS scales.Results:The scores of Y-BOCS,CGI-SI and HAMD scales in observed group were significantly lower than that in control group at the end of 4 weeks,8 weeks and 6 month after the treatment(P0.05,respectively).There was no significant difference in side effects between the two groups(P0.05).Conclusion:Relaxation training combined with Paroxetine was more effective than Paroxetine mono-therapy in thetreatment of OCD.
Paroxetine
Relaxation Therapy
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观察临床的功效和 Paroxetine 的不利反应的目的在对待消沉与电镀物品针灸(EA ) 结合了。有消沉的 42 个病人随机被分到与 EA 对待的观察组(22 个病人) 的方法与 Paroxetine，和独自与 Paroxetine 对待的控制组(20 个病人) 结合了，并且为两个组的治疗学的功课是 6 个星期。治疗效能和不利反应被哈密尔顿消沉规模(HAMD ) 和突现的症状放大的治疗(TESS ) 分别地与分数评估。在结束决定的结果 HAMD 分数第一，第二，治疗功课的第 4，和第 6 星期比在控制组(P<0.05 ) 的那些在观察组是显著地更低的。在 6 星期的治疗的结束评估的重要改进率在控制组(72.7% 对 40.0%) 比那在观察组是显著地更高的。TESS 分数的有效差量都没在二个组之间被发现。与 Paroxetine 相结合的结论 EA 独自比 Paroxetine 的有更好临床的功效，与更温和的不利反应和效果的更快的开始。
Paroxetine
Depression
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Paroxetine is an antidepressant included in the group of selective serotonin reuptake inhibitors (SSRI) with antidepressant and anxiolytic properties. A rarely seen adverse effect of paroxetine is dermatological reactions. Commonly seen reactions to paroxetine are eczematous reactions and benign skin lesions in general, while some clinical pictures such as life-threatening Stevens–Johnson syndrome and toxic epidermal necrolysis can also be seen. A case of a female patient who developed urticaria during paroxetine use is discussed in this paper.
Paroxetine
Toxic Epidermal Necrolysis
Serotonin reuptake inhibitor
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Paroxetine is a commonly used antidepressant with a safe side-effect profile. A case of paroxetine overdose (560 mg) is reported in an 18-year-old female who attempted suicide and recovered without any sequelae, requiring only supportive treatment. This report highlights a case of pure paroxetine overdose and the safety profile of paroxetine in overdose.
Paroxetine
Drug overdose
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