PCV96 Relationship Between Inflammation and Patient Functioning in Cardiovascular Disease: A Review of the Literature
0
Citation
0
Reference
10
Related Paper
Keywords:
Irritability
Depression
Neopterin
Correlation of Serum Interferon Gamma and Neopterin Concentrations in Africans with Various Diseases
Summary Concentrations of interferon gamma in serum and of neopterin in serum and urine were determined in 55 Tanzanians attending a local hospital for various diseases or complaints. For comparison, serum concentrations of interferon gamma and of neopterin were also measured in 76 clinically healthy Austrian blood donors. Both interferon gamma and neopterin concentrations were significantly higher in patients than in blood donors. Both analytes were significantly correlated with each other, and both exhibited similar behaviour in dependence on clinical diagnosis. The results support use of neopterin determination for indirect measurement of endogenous production of interferon gamma.
Neopterin
Cite
Citations (5)
Neopterin
Cite
Citations (27)
This study was undertaken to identify the clinical and pathoanatomical correlates of irritability in patients with closed head injuries. A consecutive series of 66 patients was assessed in hospital and at 3, 6, 9, and 12-month follow-ups. Patients fulfilling criteria for irritability were divided into 2 groups based on the immediate or delayed onset of their irritability and compared with patients without irritability for background characteristics, impairment variables, and lesion characteristics. There were 12 patients (18.2%) with acute onset irritability and 10 (15.1%) with delayed onset irritability. Acute onset irritability patients had a higher frequency of left cortical lesions. Delayed onset irritability patients showed a strong association with poor social functioning and greater impairment in activities of daily living. The findings suggest that post-brain injury irritability may have different causes and treatment in the acute and chronic stages.
Irritability
Cite
Citations (64)
Abstract Increased serum or urinary concentrations of neopterin have been described in patients with tumors of different primary locations, but reports on neopterin in patients with melanoma are scanty. We have studied serum neopterin and a melanoma marker, S-100-beta, in 41 patients with melanoma. Serum neopterin and S-100-beta were determined by immunoassay. Neopterin concentrations were significantly increased compared to controls only in patients with active disease, but not in patients without evidence of disease activity. Serum neopterin and S-100-beta in patients with active disease were higher than in patients without evidence of disease activity. In patients a significant correlation existed between neopterin and S-100-beta (r s = 0.33, p <0.05), and, in patients without active disease, there was also a correlation between neopterin and age (r s = 0.51, p <0.01). In conclusion, increased serum neopterin in patients reflects disease activity. A significant correlation was observed between serum neopterin and S-100-beta. Future studies are necessary to demonstrate whether the combined measurement of serum neopterin and S-100-beta could be useful in the detection of recurrence in patients with melanoma.
Neopterin
Cite
Citations (0)
瞄准：评估有孩子的肝功能测试和组织学的等级的浆液 neopterin 层次和他们与 hepatitis-B-related 的关联长期的肝疾病。方法：学习人口与长期的活跃肝炎 B 包括了 48 个病人，有 hepatitis-B-related 的 32 个病人活跃的肝肝硬化和 40 正常控制。浆液 neopterin 用连接酶的免疫吸着剂试金被测量。结果：吝啬的 +/- SD 浆液 neopterin 层次是 14.2 +/- 在有长期的肝炎的病人的 5.6 nmol/L， 20.3 +/- 在有在控制的 1.4 nmol/L 组织的肝肝硬化和 5.2 +/- 的病人的 7.9 nmol/L。浆液 neopterin 层次在有长期的肝炎的病人是显著地更高的(P = 0.005 ) 并且肝硬化病人(P = 0.008 ) ，比在控制题目。肝脏硬化症的病人与长期的肝炎比病人有显著地更高的浆液 neopterin 层次(P = 0.004 ) 。在有长期的肝炎的病人在浆液 neopterin 层次和丙氨酸 aminotransferase 层次之间有积极关联(r = 0.41， P = 0.004 ) 并且肝脏硬化症的病人(r = 0.39， P = 0.005 ) 。积极关联与长期的肝炎在病人在浆液 neopterin 层次和煽动性的分数之间被检测(r = 0.51， P = 0.003 ) 并且肝脏硬化症的病人(r = 0.49， P = 0.001 ) 。结论：我们的结果建议浆液 neopterin 层次能与 hepatitis-B-related 在孩子被看作煽动性的活动的一个标记和疾病的严厉长期的肝疾病。
Neopterin
Liver disease
Cite
Citations (1)
Neopterin
Cell mediated immunity
Cite
Citations (8)
Neopterin, a pteridine intermediate metabolite in the biopterine synthetic pathway, is synthesized and secreted by monocyte/macrophages upon stimulation, mainly by gamma-interferon by activated T cells. C-reactive protein (CRP) is one of the major acute phase reactants and its release is thought to be mediated by interleukin-6. Soluble IL-2 receptor (sIL-2R) is released by activated T cells. Plasma concentrations of neopterin, CRP and sIL-2R were synchronously analyzed in 25 determinations of 5 patients with severe infectious complications. A marked increase in neopterin, CRP and sIL-2R levels was observed. The increase in neopterin was significantly correlated to that of neopterin which is a marker of macrophage activity. These results suggest that macrophages are involved in the stimulation of sIL-2R release. In contrast, the increase in neopterin was not correlated to that of CRP and the lack of correlation between neopterin and CRP indicated that independent mechanisms control the synthesis of these two markers.
Neopterin
Monocyte
Pteridine
Cite
Citations (1)
Neopterin has been extensively used as a clinical marker of immune activation during inflammation in a wide range of conditions and stresses. However, the analysis of neopterin alone neglects the cellular reactions that generate it in response to interferon-γ. Neopterin is the oxidation product of 7,8-dihydroneopterin, which is a potent antioxidant generated by interferon-γ-activated macrophages. 7,8-Dihydroneopterin can protect macrophage cells from a range of oxidants through a scavenging reaction that generates either neopterin or dihydroxanthopterin, depending on the oxidant. Therefore, plasma and urinary neopterin levels are dependent on both macrophage activation to generate 7,8-dihydroneopterin and subsequent oxidation to neopterin. This relationship is clearly shown in studies of exercise and impact-induced injury during intense contact sport. Here, we argue that neopterin and total neopterin, which is the combined value of 7,8-dihydroneopterin and neopterin, could provide a more comprehensive analysis of clinical inflammation than neopterin alone.
Neopterin
Cite
Citations (78)
Irritability
Cite
Citations (12)
Abstract The main goal of the present study was to detect neopterin concentrations in human tear samples and to evaluate its potential correlation with serum neopterin levels. For this purpose, 20 systemically healthy volunteers were recruited, and both tear and serum samples were synchronically collected from each individual. Enzyme-linked immunoassay (ELISA) was carried out to detect the quantity of neopterin in the samples. Mean human tear neopterin levels were observed as 3±0.56 nM while mean serum neopterin was 9±1.25 nM. Additionally, a significant positive correlation between tear neopterin and serum neopterin concentrations was observed. This is the first report to show neopterin concentration in human tears as a biological sample. Collecting tears from the individuals is a non-invasive sampling method, and as an analytical aspect detection of neopterin by ELISA in tear samples construct a valuable, practical and cheap procedure for the diagnosis and monitoring of intraocular inflammation and systemic immune-mediated diseases.
Neopterin
Cite
Citations (9)