Treatment with low-dose cytosine arabinoside followed by administration of macrophage colony-stimulating factor prolongs the survival of patients with RAEB, RAEB-T, or leukemic phase myelodysplastic syndrome: a pilot study.

PubMed (2000)

Takashi Fukuhara Takayoshi Miyake I Maekawa M Kurosawa Sachiko Suzuki Satoshi Noto A Mori Kōji Chiba T Toyoshima Tadanori Hirano Masanobu Morioka Yutaka Tsutsumi M Okabe Yasutaka Kakinoki

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Keywords:

Hematology

Refractory (planetary science)

Topics:

Acute Myeloid Leukemia Research

Acute Lymphoblastic Leukemia research

Polyomavirus and related diseases

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The Search for Better Prognostic Models in Myelodysplastic Syndromes

Current Hematologic Malignancy Reports (2010)

Fabio P S Santos Hagop M. Kantarjian Guillermo Garcia‐Manero Farhad Ravandi

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Bone marrow failure

10.1007/s11899-010-0070-x

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Chemotherapy for patients with acute myeloid leukemia in first remission

Current Hematologic Malignancy Reports (2006)

Kenneth F. Bradstock

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Citations (5)

High‐dose cytosine arabinoside and amsacrine or mitoxantrone in relapsed and refractory acute myeloid leukaemia: a prospective randomized study

European Journal Of Haematology (1990)

Philippe Martiat J M Ghilain Augustin Ferrant Chantal Doyen André Delannoy

52 patients with refractory or relapsed acute myeloid leukaemia (AML) were randomly assigned to receive a combination of high‐dose cytosine arabinoside (HD Ara‐C), 3 g/m 2 /d and either mitoxantrone (MTX), 7 mg/m 2 /d (5 mg if older than 60 yr) or m‐amsacrine (AMSA), 120 mg/m 2 /d (90 mg if older than 60 yr) for 5 d. The overall response rate was 50% and did not differ significantly in the two groups (46% for AMSA and 56% for MTX, p = 0.415). The median survival was 11 months (8 months for AMSA and 12 months for MTX, p = 0.326) and the median duration of complete remission (CR) was 11 months for AMSA and 12 months for MTX (p = 0.643). In relapsed patients, the only significant predictive factor for obtaining a complete response was the length of first complete remission. Patients with a first CR shorter than 6 months had a CR rate of 36% while it was 65% if the first CR lasted more than 6 months (p = 0.03). Severe (WHO grade III‐IV) gastro‐intestinal toxicity was more frequent in the AMSA group (27% vs 4%, p = 0.021). Treatment‐related death occurred in 4 patients in the AMSA group and in 2 patients in the MTX group (p = 0.097). We conclude that neither of these two treatment modalities was shown to be superior in terms of CR rate and survival, with a better tolerance for MTX.

Amsacrine

Mitoxantrone

Refractory (planetary science)

Cytosine

10.1111/j.1600-0609.1990.tb00445.x

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Citations (26)

Treatment of acute myeloid leukemia and myelodysplastic syndrome with orally administered cytarabine ocfosfate and granulocyte colony-stimulating factor.

International Journal of Hematology (1997)

Okumura

Hematology

10.1016/s0925-5710(96)00572-5