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    The role of empathy in the motivational structure of school children
    Personality and Individual Differences (1992)
    Béla KozékiRita Berghammer
    Citations (26)
    Primate Nigrostriatal Dopamine System Regulates Saccadic Response Inhibition
    Neuron (2018)
    Takaya OgasawaraMasafumi NejimeMasahiko TakadaMasayuki Matsumoto
    Dopaminergic pathways
    Nigrostriatal pathway
    Premovement neuronal activity
    Citations (32)
    Role for dopamine in the behavioral functions of the prefrontal corticostriatal system: implications for mental disorders and psychotropic drug action
    Progress in brain research (2000)
    J. David JentschRobert H. RothJane R. Taylor
    Forebrain
    Dopaminergic pathways
    Citations (97)
    The weaver mutant mouse: a model to study the ontogeny of dopamine transmission systems and their role in drug addiction
    Progress in Neurobiology (2001)
    Pratibha MaharajanVeeramani MaharajanGiampietro RavagnanG. Paino
    Dopaminergic pathways
    Citations (22)
    Function and Regulation of ALDH1A1-Positive Nigrostriatal Dopaminergic Neurons in Motor Control and Parkinson’s Disease
    Frontiers in Neural Circuits (2021)
    Kathleen CarmichaelRebekah C. EvansE LópezLixin SunMantosh Kumar
    Dopamine is an important chemical messenger in the brain, which modulates movement, reward, motivation, and memory. Different populations of neurons can produce and release dopamine in the brain and regulate different behaviors. Here we focus our discussion on a small but distinct group of dopamine-producing neurons, which display the most profound loss in the ventral
    Nigrostriatal pathway
    Citations (35)
    Neurotransmitter regulation of dopamine neurons in the ventral tegmental area
    Brain Research Reviews (1993)
    Peter W. Kalivas
    Citations (715)
    Reinforcement signalling in Drosophila; dopamine does it all after all
    Current Opinion in Neurobiology (2013)
    Scott Waddell
    Octopamine (neurotransmitter)
    Punishment (psychology)
    Neuroscientist
    Reward system
    Biological neural network
    Citations (262)
    Dopamine neuron systems in the brain: an update
    Trends in Neurosciences (2007)
    Anders BjörklundStephen B. Dunnett
    Neurochemical
    Citations (1,631)
    Dopamine: at the intersection of reward and action
    Nature Neuroscience (2007)
    Nathaniel D. Daw
    Neuroscientist
    Citations (55)
    A Modeling Study Suggesting a Possible Pharmacological Target to Mitigate the Effects of Ethanol on Reward-Related Dopaminergic Signaling
    Journal of Neurophysiology (2008)
    Michele MiglioreClaudio CanniaCarmen C. Canavier
    Midbrain dopaminergic neurons are involved in several critical brain functions controlling goal-directed behaviors, reinforcing/reward processes, and motivation. Their dysfunctions alter dopamine release and contribute to a vast range of neural disorders, from Parkinson's disease to schizophrenia and addictive behaviors. These neurons have thus been a natural target of pharmacological treatments trying to ameliorate the consequences of several neuropathologies. From this point of view, a clear experimental link has been recently established between the increase in the pacemaker frequency of dopaminergic neurons in vitro after acute ethanol application and a particular ionic current ( I h ). The functional consequences in vivo, however, are not clear and they are very difficult to explore experimentally. Here we use a realistic computational model of dopaminergic neurons in vivo to suggest that ethanol, through its effects on I h , modifies the temporal structure of the spiking activity. The model predicts that the dopamine level may increase much more during bursting than during pacemaking activity, especially in those brain regions with a slow dopamine clearance rate. The results suggest that a selective pharmacological remedy could thus be devised against the rewarding effects of ethanol that are postulated to mediate alcohol abuse and addiction, targeting the specific HCN genes expressed in dopaminergic neurons.
    Bursting
    Dopaminergic pathways
    Premovement neuronal activity
    Citations (26)