Cardiac Troponin I in Doberman Pinschers with Cardiomyopathy
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Abstract:
Cardiac troponin I (cTnI) is useful for detection of cardiac myocyte damage, but its efficacy in detecting various stages of dilated cardiomyopathy (DCM) in Doberman Pinschers is unclear.To evaluate the diagnostic value of cTnI in various stages of DCM in Dobermans.Six hundred and fifty-three cTnI measurements of 336 Doberman Pinschers.Using a longitudinal study design, staging of the disease was based upon 24-hour-ambulatory-ECG (Holter) and echocardiography. A total of 447 cTnI measurements were performed in 264 healthy Dobermans, and 206 cTnI measurements in 75 Dobermans with cardiomyopathy. Eighty-eight cTnI samples were from dogs with >100 ventricular premature contractions (VPCs)/24 hour, but without echocardiographic changes ("VPC group"). Additional 19 samples originated from dogs with only echocardiographic changes ("ECHO group"), and 56 samples from dogs with both VPCs and echocardiographic changes ("VPC plus ECHO group"). Twenty samples were from dogs with clinical signs ("clinical group"). The group "incipient" included 23 dogs, that were considered to be normal according to Holter and echocardiography at the time of the exam, but that developed DCM within 1.5 years.cTnI values of dogs in all disease groups, including the "incipient" (0.30+/-0.20) and "VPC group" (0.36+/-0.34), were significantly (P=.04, P<.001) higher than the control group (0.07+/-0.16). A cut-off value of >0.22 ng/mL had a sensitivity of 79.5% and a specificity of 84.4% to detect all forms of cardiomyopathy.cTnI measurement is a valuable diagnostic test that can detect cardiomyopathy in dogs that are otherwise clinically normal.Keywords:
Dilated Cardiomyopathy
Familial hypertrophic cardiomyopathy (FHCM) is an autosomal dominant disorder.More than 200 mutations for thirteen genes are ilnvolved in FHCM,which result from all encoding components of the contractile apparatus of the cardiac myocyte.Troponin T (TnT) is one of the three subunits that form troponin complex which is responsible for the regulation of striated muscle contraction together with tropomyosin.In fact,the TNNT2 gene is the third most common gene responsible for familial hypertrophic cardiomyopathy,accounting for approximately 15%～20% of all cases.The mutations in cardiac tmponin T gene appear to be associated with incomplete penetrance and poor prognosis of the family hypertrophic cardiomyopathy.TNNT2 mutations are clustered in its two domains.The study on the molecular mechanism for hypertrophic cardiomyopathy caused by TnT can lead to improved genetic counseling and better clinical management in families with HCM.
Key words:
Hypertrophic cardiomyopathy; Troponin T; Mutation
Penetrance
Restrictive cardiomyopathy
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Background The use of cardiac biomarkers to assist in the diagnosis of occult and symptomatic hypertrophic cardiomyopathy ( HCM ) in cats has been established. There is limited data describing their prognostic utility in cats with HCM . Hypothesis Circulating concentrations of N‐terminal B‐type natriuretic peptide (NTproBNP) and cardiac troponin I ( cTnI ) predict cardiac death in cats with HCM . Animals Forty‐one cats diagnosed with HCM at a veterinary teaching hospital, between February 2010 and May 2011. Methods Prospective investigational study. Plasma samples were collected from cats diagnosed with HCM and concentrations of NTproBNP and cTnI were analyzed at a commercial laboratory. Echocardiographic measurements from the day of blood sampling were recorded. Long‐term outcome data were obtained. Associations with time to cardiac death were analyzed using Cox proportional hazards models. Results When controlling for the presence/absence of heart failure and echocardiographic measures of left atrial size and function, cTnI > 0.7 ng/mL was independently associated with time to cardiac death. In univariable analysis, NTproBNP > 250 pmol/L was associated with cardiac death ( P = .023), but this did not remain significant ( P = .951) when controlling for the effect of clinical signs or left atrial size/function. Conclusions and Clinical Importance Plasma concentration of cTnI (cutoff >0.7 ng/mL) is a predictor of cardiac death in cats with HCM that is independent of the presence of heart failure or left atrial dilatation.
Occult
Blood sampling
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Dilated Cardiomyopathy
Cardiac magnetic resonance
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Contraction of cardiac muscle is regulated by the thin filament through Ca2+ binding to the troponin C subunit of the troponin (Tn) complex, composed of troponin I (TnI), troponin T and troponin C ...
Troponin T
Troponin complex
Troponin C
Dilated Cardiomyopathy
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Single-strand conformation polymorphism
Troponin T
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Dilated Cardiomyopathy
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Troponin complex
Cardiac muscle
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Objective:To explore the feasibility of the diagnosis of hypertrophic cardiomyopathy through analyzing clinical symptoms and signs,electrocardiogram and echocardiography,and to discuss the causes of misdiagnosis. Method:The clinical data of 36 cases with hypertrophic cardiomyopathy was analyzed. Result:Hypertrophic cardiomyopathy has diverse clinical manifestations and lack of specificity.So it is easy to be misdiagnosed,which requires us to make comprehensive consideration.Echocardiography examination can be used as the preferred method of clinical diagnosis and review. Conclusion:In order to reduce the rate of misdiagnosis and to early treat,we should improve the understanding of hypertrophic cardiomyopathy.
Clinical Diagnosis
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