Mesoporous Silica Nanomaterial-Based Biotechnological and Biomedical Delivery Systems
157
Citation
55
Reference
10
Related Paper
Citation Trend
Abstract:
This review details the recent advancements in the design of mesoporous silica nanomaterials for controlled release drug, gene and neurotransmitter delivery applications. The high surface area (>900 m2/g), tunable pore diameter (2–20 nm) and uniform mesoporous structure (hexagonal channels or cubic pores) of the mesoporous silicas offer a unique advantage for loading and releasing large quantities of biomedical agents. Recent breakthroughs in controlling the particle size and shape of these materials have greatly improved the biocompatibility and the cellular uptake efficiency. The strategy of using various removable capping moieties, such as photo- or redox-responsive organic groups, inorganic nanoparticles, dendrimers and polymers, to encapsulate guest biomolecules inside the porous matrices further enables the utilization of these surface-functionalized mesoporous silica nanomaterials for stimuli-responsive controlled release in vitro and in vivo. In addition to the reviewed studies, many new and exciting applications of these novel materials will soon be realized.Keywords:
Nanomaterials
Mesoporous organosilica
Biocompatibility
Biomolecule
Surface Modification
Specific surface area
Mesoporous silica with hexagonal type structure containing amine functional group was introduced. Firstly, aminopropyl hexagonal mesoporous silica was synthetized in a co-condensation process, via templating route of n-dodecylamine. Then synthesized mesoporous material were characterized, and FT-IR spectrum confirmed the presence of amine group and CHN analysis determined the amount of organic layer. The high surface area (750 m2/g) was determined by applying nitrogen adsorption-desorption technique. The morphology was examined by scanning electron microscopy which proved hexagonal structure. The crystallinity of mesoporous material was observed in XRD pattern of this material. According to previous background of such material in adsorbing drug, herein, the efficiency of this material in adsorbing of 5-fluorouracil was evaluated through solid phase extraction method in aqueous and plasma media with high performance liquid chromatography. The extraction efficiency was evaluated for drug concentrations of 500-2000 ng/ml by means of 5-20 mg/ml hexagonal mesoporous silica in both media. The results showed good to excellent recovery rate of in both aqueous and plasma medium which confirmed that the aminopropyl functionalized hexagonal mesoporous silica could be considered as promising device for drug bioanalysis.
Mesoporous organosilica
Hexagonal phase
Cite
Citations (14)
Mesoporous organosilica
MCM-41
Surface Modification
Cite
Citations (172)
Under alkaline condition,using cetyl trimethyl ammonium bromide as the template agent,and tetraethyl orthosilicate as silica sources,with the hydrothermal method and trimethylbenzene to expand the mesoporous silica's size,there modified a kind of mesoporous silica.Using BET,FT-IR and small angle XRD to analyze and characterize mesoporoue silica.In addition,the mesoporous silica's adsorption capacity of lead ion was tested,which shows that the capacity of expanded mesoporous silica is higher than the one haven't be expanded.The adsorption rate of Pb2+is 99.8%.
Ammonium bromide
Mesoporous organosilica
Cite
Citations (0)
Abstract We report the fabrication of highly densified mesoporous bulk silica consisting of colloidal mesoporous silica nanoparticles (MSNs) by using a hydrothermal hot-pressing method. No cracks or voids are found in the synthesized bulk. The mesoporous structure of the bulk is maintained as well as that of the original MSNs. The MSN-based bulk with large pore volume shows potential as a low-k material.
Mesoporous organosilica
Colloidal Silica
Cite
Citations (3)
等. 然而, 传统的介孔二氧化硅小球具有孔容积小、孔道 深等特点, 使得其负载药物量较少, 而且其负载的药 物分子的扩散需要很长的时间, 因此需要研发提高 载药量且利于药物释放的新型二氧化硅载体材料.最近, 一些文献报道了采用模板法先制备核壳结构, 然后通过溶液刻蚀除去模板得到中空结构介孔二氧 化硅小球.然而, 这些合成方法不但费时费力, 而且 刻蚀会对中空结构的二氧化硅小球形貌、 孔径分布造 成一定的影响 [15~19] .因此, 高效的合成方法有待进一 步提出.本文采用模板法, 如图 1(a)所示, 以聚苯乙烯-丙烯酸-甲基丙烯酸甲酯共聚物微球为模板, 十六烷 基三甲基溴化铵(CTAB)为造孔剂, 通过加入适量的 正硅酸四乙酯(TEOS), 在一定量的聚苯乙烯-丙烯酸-甲基丙烯酸甲酯共聚物微球外面生长介孔二氧化硅 来合成聚苯乙烯-丙烯酸-甲基丙烯酸甲酯共聚物微 球@SiO 2 核壳结构, 然后通过高温煅烧除去聚苯乙烯-
Cite
Citations (2)
Hexagonal mesoporous silica MCM-41 and SBA-3 were synthesized in basic or acidic medium by using mixed surfactants cetyltrimethy lammonium bromide and n-dodecylamine. X-ray diffraction and N 2 adsorption isotherm showed that the synthesized silica exhibited a well-ordered hexagonal pore structure and mesoporous pore size distributions. The effects of TMAOH/Si on the structural properties of the MCM-41 and HCl/Si on the SBA-3 were investigated. It was found that the hexagonal mesoporous silica can be formed with lower molar ratio of mixed surfactants to silica from 0.2460 to 0.264.
Mesoporous organosilica
Template
MCM-41
Cite
Citations (0)
Highly ordered mesoporous silica, SBA-15 was synthesized using triblock copolymer (P123) as template and tetraethyl orthosilicate (TEOS) as silica source. Through the post-synthesis treatment, pore surface of the mesoporous silica was modified with aminosilane and then Eu3+ ions were incorporated in the modified mesoporous silica for the formation of Eu complex. Mesoporous silica with the hexagonal mesostructure was characterized by small angle X-ray scattering (SAXS) and transmission electron microscopy (TEM). The successful modification of the mesoporous silica was verified by FT-IR spectra and nitrogen adsorption/desorption isotherms. Eu incorporated mesoporous silicas showed different photoluminescent intensities depending on the pH of acidic and basic aqueous solutions.
Mesoporous organosilica
Europium
Small-angle X-ray scattering
Cite
Citations (5)
Silsesquioxane
Mesoporous organosilica
Biocompatible material
Cite
Citations (245)
Mesoporous organosilica
Biocompatibility
Bovine serum albumin
Biomolecule
Cite
Citations (116)
It has been more than 30 years since the first ordered mesoporous silica molecular sieve (MCM-41) was reported, but the enthusiasm for exploiting mesoporous silica is still growing due to its superior properties, such as its controllable morphology, excellent hosting capability, easy functionalization, and good biocompatibility. In this narrative review, the brief history of the discovery of mesoporous silica and several important mesoporous silica families are summarized. The development of mesoporous silica microspheres with nanoscale dimensions, hollow mesoporous silica microspheres, and dendritic mesoporous silica nanospheres is also described. Meanwhile, common synthesis methods for traditional mesoporous silica, mesoporous silica microspheres, and hollow mesoporous silica microspheres are discussed. Then, we introduce the biological applications of mesoporous silica in fields such as drug delivery, bioimaging, and biosensing. We hope this review will help people to understand the history of the development of mesoporous silica molecular sieves and become familiar with their synthesis methods and applications in biology.
Mesoporous organosilica
Biocompatibility
Cite
Citations (23)