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    Acute alcohol blocks neurosteroid modulation of synaptic transmission and long-term potentiation in the rat hippocampal slice
    Brain Research (1995)
    R. D. RandallS.Y. LeeJ. Harlan MeyerGeorge F. WittenbergDonna L. Gruol
    31
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    66
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    10
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    Keywords:
    Schaffer collateral
    LTP induction
    Topics:
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    The AAA+ ATPase Thorase Regulates AMPA Receptor-Dependent Synaptic Plasticity and Behavior
    Cell (2011)
    Jianmin ZhangYue WangZhikai ChiMatthew J. KeussYing-Min Emily Pai
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    Long-term depression
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    A possible regulatory role of dendritic action potentials in LTP induction at hippocampal Schaffer collateral-CA1 synapses
    Neuroscience Research (2000)
    Yoshikazu Isomura
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    LTP induction
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    Low Dose ZD7288 Attenuates the Ischemia/Reperfusion-Induced Impairment of Long-Term Potentiation Induction at Hippocampal Schaffer Collateral-CA1 Synapses
    Cellular and Molecular Neurobiology (2014)
    Wei HeXulin XuQing LvLianjun Guo
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    Schaffer collateral
    Excitotoxicity
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    Developmental switch in requirement for PKA RIIβ in NMDA-receptor-dependent synaptic plasticity at Schaffer collateral to CA1 pyramidal cell synapses
    Neuropharmacology (2008)
    Yupeng YangKoichi TakeuchiAlma Rodenas-RuanoYukihiro TakayasuMichael V. L. Bennett
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    Neuronal memory allocation
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    AMPA receptor antagonists, GYKI 52466 and NBQX, do not block the induction of long-term potentiation at therapeutically relevant concentrations
    Brain Research Bulletin (2000)
    Gábor KapusJózsef I. SzékelyJ. DurandArnaud RuizIstván Tarnawa
    NBQX
    Schaffer collateral
    LTP induction
    Population spike
    Citations (21)
    Low-frequency activation of the NMDA receptor system can prevent the induction of LTP
    Neuroscience Letters (1989)
    E.J. CoanAndy J. IrvingGraham L. Collingridge
    Schaffer collateral
    LTP induction
    Tetanic stimulation
    2-Amino-5-phosphonovalerate
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    Synaptic AMPA Receptor Exchange Maintains Bidirectional Plasticity
    Neuron (2006)
    Stefanie G. McCormackRuth L. StornettaJie Zhu
    Synaptic scaling
    Citations (93)
    PDZ binding of TARPγ-8 controls synaptic transmission but not synaptic plasticity
    Nature Neuroscience (2011)
    Akio SumiokaTravis E. BrownAkihiko KatoDavid S. BredtJulie A. Kauer
    PDZ domain
    Synaptic scaling
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    A focal adhesion-like process underlies induction of long-term potentiation in the Schaffer collateral-CA1 region of the hippocampus
    Neuron Glia Biology (2004)
    Richard G. LeBaronRubén HernándezMary M. NavarroLISA R. CURRYJames E. Orfila
    In the series of experiments reported here we provide evidence that a focal adhesion-like process underlies the induction of long-term potentiation (LTP) in the Schaffer Collateral-CA1 projection in the hippocampus. Here we show that an integrin binding peptide (RGD) impairs induction of Schaffer Collateral-CA1 LTP in hippocampal slice preparations in vitro. The heparin-binding peptide that binds heparan sulfate proteoglycan (HSPG) and blocks the formation of focal adhesions also impairs induction of LTP. Either the integrin-binding peptide or heparin-binding peptide reduces LTP partially. However, when the two peptides were administered simultaneously, there was no LTP 1 hour after induction. This indicates that these two molecules might function together and that a focal adhesion-like process might be involved in the induction of LTP. Additionally,we report that the RGD effect on LTP is time dependent and occurs only in the first few minutes following LTP induction, that the binding of the RGD peptide in CA1 stratum radiatum increases after LTP induction and that this increased binding depends on Ca(2+). Using electron microscopy we show that integrins are present in synapses.
    Schaffer collateral
    LTP induction
    Citations (0)
    MK-801 Prevents the Induction of Long-Term Potentiation
    Springer eBooks (1988)
    E.J. CoanW. SaywoodG.L. Collingridge
    Schaffer collateral
    LTP induction
    Long-term depression
    Citations (1)